Cilia and Flagella Revealed From Flagellar Assembly in Chlamydomonas to Human Obesity Disorders

The recent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia and flagella has triggered a renaissance of interest in these organelles that transcends studies on their well-characterized ability to move. New studies on several fronts have revealed that the machinery for flagellar assembly/disassembly is regulated by homologs of mitotic proteins, that cilia play essential roles in sensory transduction, and that mutations in cilia/basal body proteins are responsible for cilia-related human disorders from polycystic kidney disease to a syndrome associated with obesity, hypertension, and diabetes.

[1]  Tanya M. Teslovich,et al.  Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome , 2003, Nature.

[2]  S. Geimer,et al.  The Microtubule Plus End-Tracking Protein EB1 Is Localized to the Flagellar Tip and Basal Bodies in Chlamydomonas reinhardtii , 2003, Current Biology.

[3]  L. Ostrowski,et al.  A Proteomic Analysis of Human Cilia , 2002, Molecular & Cellular Proteomics.

[4]  G. Pazour,et al.  Chlamydomonas IFT88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg737, Are Required for Assembly of Cilia and Flagella , 2000, The Journal of cell biology.

[5]  W. Snell,et al.  An aurora kinase is essential for flagellar disassembly in Chlamydomonas. , 2004, Developmental cell.

[6]  W. Snell,et al.  Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas. , 2002, Molecular biology of the cell.

[7]  P. Beech,et al.  Chlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons , 1998, The Journal of cell biology.

[8]  W. Marshall,et al.  Intraflagellar transport balances continuous turnover of outer doublet microtubules , 2001, The Journal of cell biology.

[9]  K. Kozminski,et al.  A motility in the eukaryotic flagellum unrelated to flagellar beating. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[10]  G. Germino,et al.  Role of polycystins in renal tubulogenesis. , 2003, Trends in cell biology.

[11]  G. Pazour,et al.  The vertebrate primary cilium is a sensory organelle. , 2003, Current opinion in cell biology.

[12]  Massimo Sassaroli,et al.  Protein Particles in Chlamydomonas Flagella Undergo a Transport Cycle Consisting of Four Phases , 2001, The Journal of cell biology.

[13]  Bethan E. Hoskins,et al.  The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression , 2004, Nature Genetics.

[14]  P. Lefebvre,et al.  A Novel MAP Kinase Regulates Flagellar Length in Chlamydomonas , 2003, Current Biology.

[15]  Shankar Subramaniam,et al.  Decoding Cilia Function Defining Specialized Genes Required for Compartmentalized Cilia Biogenesis , 2004, Cell.

[16]  Tanya M. Teslovich,et al.  Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene , 2004, Cell.

[17]  S. Geimer,et al.  Intraflagellar transport (IFT) cargo , 2004, The Journal of cell biology.

[18]  W. Snell,et al.  Flagellar Adhesion between Mating Type Plus and Mating Type Minus Gametes Activates a Flagellar Protein-tyrosine Kinase during Fertilization in Chlamydomonas* , 2003, Journal of Biological Chemistry.

[19]  Lee Niswander,et al.  Hedgehog signalling in the mouse requires intraflagellar transport proteins , 2003, Nature.