Wavelet-Based EEG Processing for Epilepsy Detection Using Fuzzy Entropy and Associative Petri Net

Epilepsy is a common neurological disease that can cause seizures and loss of consciousness and can have a severe negative impact on long-term cognitive function. Reducing the severity of impact requires early diagnosis and treatment. Epilepsy is traditionally diagnosed using electroencephalography (EEG) performed by trained physicians or technicians but this process is time-consuming and prone to interference, which can negatively impact accuracy. This paper develops a model for epilepsy diagnosis using discrete wavelet transform to analyze sub-bands within the EEG parameter and select EEG characteristics for epilepsy detection. The minimize entropy principle approach is used to build fuzzy membership functions of the characteristics of each brain wave and are then used as the basis for the construction of an associative Petri net model. Using our APN model, the associative Petri net approach provides diagnosis accuracy rates of 93.8%, outperforming similar approaches using decision tree, support vector machine, neural network, Bayes net, naïve Bayes, and tree augmented naïve Bayes. Thus, the proposed approach shows promise for fast, accurate, and objective diagnosis of epilepsy in clinical settings.

[1]  Dimitrios I. Fotiadis,et al.  Epileptic Seizure Detection in EEGs Using Time–Frequency Analysis , 2009, IEEE Transactions on Information Technology in Biomedicine.

[2]  Daniel Rivero,et al.  Epileptic seizure detection using multiwavelet transform based approximate entropy and artificial neural networks , 2010, Journal of Neuroscience Methods.

[3]  Ingrid Daubechies,et al.  The wavelet transform, time-frequency localization and signal analysis , 1990, IEEE Trans. Inf. Theory.

[4]  Elif Derya Übeyli,et al.  Features extracted by eigenvector methods for detecting variability of EEG signals , 2007, Pattern Recognit. Lett..

[5]  Guangyi Chen,et al.  Automatic EEG seizure detection using dual-tree complex wavelet-Fourier features , 2014, Expert Syst. Appl..

[6]  B. Dworetzky,et al.  The role of the interictal EEG in selecting candidates for resective epilepsy surgery , 2011, Epilepsy & Behavior.

[7]  P. Wong,et al.  Spikes and Epilepsy , 2009, Clinical EEG and neuroscience.

[8]  Tomasz Imielinski,et al.  Database Mining: A Performance Perspective , 1993, IEEE Trans. Knowl. Data Eng..

[9]  U. Rajendra Acharya,et al.  Use of principal component analysis for automatic classification of epileptic EEG activities in wavelet framework , 2012, Expert Syst. Appl..

[10]  Timothy J. Ross,et al.  Development of Membership Functions , 2010 .

[11]  R. Kennett Modern electroencephalography , 2012, Journal of Neurology.

[12]  Hojjat Adeli,et al.  A Wavelet-Chaos Methodology for Analysis of EEGs and EEG Subbands to Detect Seizure and Epilepsy , 2007, IEEE Transactions on Biomedical Engineering.

[13]  Elif Derya Übeyli Probabilistic neural networks combined with wavelet coefficients for analysis of electroencephalogram signals , 2009, Expert Syst. J. Knowl. Eng..

[14]  Reinhard Schulz,et al.  Postoperative routine EEG correlates with long-term seizure outcome after epilepsy surgery , 2005, Seizure.

[15]  N.E. Fenton,et al.  A Generalized Associative Petri Net for Reasoning , 2007, IEEE Transactions on Knowledge and Data Engineering.

[16]  Elif Derya Übeyli Lyapunov exponents/probabilistic neural networks for analysis of EEG signals , 2010, Expert Syst. Appl..

[17]  Jan Rémi,et al.  The role of EEG in epilepsy: A critical review , 2009, Epilepsy & Behavior.

[18]  L F Quesney,et al.  False lateralization by surface EEG of seizure onset in patients with temporal lobe epilepsy and gross focal cerebral lesions , 1987, Annals of neurology.

[19]  Antonio V. Delgado-Escueta,et al.  Interictal Epileptiform Discharges in Partial Epilepsy: Complex Neurobiological Mechanisms Based on Experimental and Clinical Evidence -- Jasper's Basic Mechanisms of the Epilepsies , 2012 .

[20]  U. Rajendra Acharya,et al.  Automatic Detection of Epileptic EEG Signals Using Higher Order cumulant Features , 2011, Int. J. Neural Syst..

[21]  João Paulo Papa,et al.  EEG signal classification for epilepsy diagnosis via optimum path forest - A systematic assessment , 2014, Neurocomputing.

[22]  Elif Derya Übeyli,et al.  Adaptive neuro-fuzzy inference system for classification of EEG signals using wavelet coefficients , 2005, Journal of Neuroscience Methods.

[23]  Elif Derya Übeyli Combined neural network model employing wavelet coefficients for EEG signals classification , 2009, Digit. Signal Process..

[24]  Daniel Rivero,et al.  Automatic feature extraction using genetic programming: An application to epileptic EEG classification , 2011, Expert Syst. Appl..

[25]  K Lehnertz,et al.  Indications of nonlinear deterministic and finite-dimensional structures in time series of brain electrical activity: dependence on recording region and brain state. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[26]  Daniel Rivero,et al.  Automatic epileptic seizure detection in EEGs based on line length feature and artificial neural networks , 2010, Journal of Neuroscience Methods.

[27]  Hsiu-Sen Chiang,et al.  Online incremental learning for sleep quality assessment using associative Petri net , 2017, Appl. Soft Comput..

[28]  Elif Derya Übeyli Decision support systems for time-varying biomedical signals: EEG signals classification , 2009, Expert Syst. Appl..

[29]  Elif Derya Übeyli Analysis of EEG signals by combining eigenvector methods and multiclass support vector machines , 2008, Comput. Biol. Medicine.

[30]  R. Fishman,et al.  CSF IgG synthesis rate in multiple sclerosis , 1987, Neurology.

[31]  Elif Derya Übeyli,et al.  Recurrent neural networks employing Lyapunov exponents for EEG signals classification , 2005, Expert Syst. Appl..

[32]  U. Rajendra Acharya,et al.  Application of Non-Linear and Wavelet Based Features for the Automated Identification of Epileptic EEG signals , 2012, Int. J. Neural Syst..