Regulatory and Signaling Properties of the Vav Family

X.R.B. is a Sinsheimer Scholar for Cancer Research whose own work is supported by the National Cancer Institute (CA7373501), the Baldwin Foundation for Breast Cancer Research, and the Association for International Cancer Research.

[1]  X. Bustelo,et al.  Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav , 2000, Molecular and Cellular Biology.

[2]  A. Weiss,et al.  A Guanine Nucleotide Exchange Factor-independent Function of Vav1 in Transcriptional Activation* , 2000, The Journal of Biological Chemistry.

[3]  X. Bustelo,et al.  Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins , 1999, Molecular and Cellular Biology.

[4]  T. Hunter,et al.  The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.

[5]  Richard Treisman,et al.  Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics , 1999, Cell.

[6]  M. Gimona,et al.  N‐terminally truncated Vav induces the formation of depolymerization‐resistant actin filaments in NIH 3T3 cells , 1999, FEBS letters.

[7]  T. Tan,et al.  Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. , 1999, Journal of immunology.

[8]  Jian Zhang,et al.  TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway. , 1999, Journal of immunology.

[9]  L. Brass,et al.  PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells. , 1999, Biochimica et biophysica acta.

[10]  M. Fujimoto,et al.  CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. , 1999, Journal of immunology.

[11]  Tony Pawson,et al.  Signaling Networks—Do All Roads Lead to the Same Genes? , 1999, Cell.

[12]  G. Koretzky,et al.  SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity* , 1999, The Journal of Biological Chemistry.

[13]  R. Abraham,et al.  Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. , 1999, International immunology.

[14]  B. Kaina,et al.  Rho GTPases are over‐expressed in human tumors , 1999, International journal of cancer.

[15]  N. Varin‐Blank,et al.  hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways , 1999, Molecular and Cellular Biology.

[16]  K. Tedford,et al.  The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28‐mediated co‐stimulation , 1999, European journal of immunology.

[17]  Y. Kaziro,et al.  G protein βγ subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25Mm , 1999 .

[18]  H. Schaeffer,et al.  Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers , 1999, Molecular and Cellular Biology.

[19]  R. Perona,et al.  Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-κB and C/EBP Transcription Factors* , 1999, The Journal of Biological Chemistry.

[20]  M. Turner,et al.  The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  L. Frati,et al.  Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity. , 1999, Journal of immunology.

[22]  Michael J. Eck,et al.  Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase , 1999, Nature.

[23]  Eric O Long,et al.  Essential role of LAT in T cell development. , 1999, Immunity.

[24]  J. Gutkind,et al.  A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho* , 1999, The Journal of Biological Chemistry.

[25]  K. Okkenhaug,et al.  Socs1 binds to multiple signalling proteins and suppresses Steel factor‐dependent proliferation , 1999, The EMBO journal.

[26]  E. Gelfand,et al.  Activation of Vav and Ras through the nerve growth factor and B cell receptors by different kinases. , 1999, Cellular immunology.

[27]  K. Toellner,et al.  Defective immunoglobulin class switching in Vav‐deficient mice is attributable to compromised T cell help , 1999, European journal of immunology.

[28]  D. Williams,et al.  Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. , 1999, Immunity.

[29]  C. Rudd Adaptors and Molecular Scaffolds in Immune Cell Signaling , 1999, Cell.

[30]  A. Weiss,et al.  Interdomain B in ZAP-70 Regulates but Is Not Required for ZAP-70 Signaling Function in Lymphocytes , 1999, Molecular and Cellular Biology.

[31]  T. Satoh,et al.  G protein bg subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1yCDC25Mm , 1999 .

[32]  Andrew C. Chan,et al.  BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells , 1999 .

[33]  T. Kurosaki,et al.  BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. , 1999, Immunity.

[34]  Kenji Nakamura,et al.  Rac1 is required for the formation of three germ layers during gastrulation , 1998, Oncogene.

[35]  J. Penninger,et al.  Vav Regulates Peptide-specific Apoptosis in Thymocytes , 1998, The Journal of experimental medicine.

[36]  J. Brugge,et al.  Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1 , 1998, Current Biology.

[37]  Z. Kam,et al.  c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. , 1998, Genes & development.

[38]  L. Tuosto,et al.  Fyn and ZAP-70 Are Required for Vav Phosphorylation in T Cells Stimulated by Antigen-presenting Cells* , 1998, The Journal of Biological Chemistry.

[39]  K. Schuebel,et al.  Phosphorylation‐dependent and constitutive activation of Rho proteins by wild‐type and oncogenic Vav‐2 , 1998, The EMBO journal.

[40]  B. Mayer,et al.  Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. , 1998, Immunity.

[41]  A. Weiss,et al.  LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway , 1998 .

[42]  A. Weiss,et al.  The Syk family of protein tyrosine kinases in T‐cell activation and development , 1998, Immunological reviews.

[43]  T. Mak,et al.  Thymocyte selection in Vav and IRF‐1 gene‐deficient mice , 1998, Immunological reviews.

[44]  W. Langdon,et al.  c‐Cbl: A regulator of T cell receptor‐mediated signalling , 1998, Immunology and cell biology.

[45]  M. Nagano,et al.  Mutagenic analysis of Vav reveals that an intact SH3 domain is required for transformation , 1998, Oncogene.

[46]  Channing J Der,et al.  Rho family proteins and Ras transformation: the RHOad less traveled gets congested , 1998, Oncogene.

[47]  C. Walsh,et al.  PAK3 mutation in nonsyndromic X-linked mental retardation , 1998, Nature Genetics.

[48]  J. C. Pratt,et al.  The Small GTP-Binding Protein Rho Potentiates AP-1 Transcription in T Cells , 1998, Molecular and Cellular Biology.

[49]  X. Bustelo,et al.  The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing , 1998, The Journal of experimental medicine.

[50]  Y. Samuels,et al.  Co‐stimulation‐dependent activation of a JNK‐kinase in T lymphocytes , 1998, European journal of immunology.

[51]  M. Fujimoto,et al.  CD19 regulates B lymphocyte responses to transmembrane signals. , 1998, Seminars in immunology.

[52]  S. Bagrodia,et al.  Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac , 1998, Molecular and Cellular Biology.

[53]  K. Tedford,et al.  Vav links antigen-receptor signaling to the actin cytoskeleton. , 1998, Seminars in immunology.

[54]  L. Samelson,et al.  LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. , 1998, Immunity.

[55]  F. Alt,et al.  Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76 , 1998, Cell.

[56]  A. Weiss,et al.  Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. , 1998, Science.

[57]  T. Stradal,et al.  CH domains revisited , 1998, FEBS letters.

[58]  D. Kioussis,et al.  Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[59]  E. Stanley,et al.  Colony-stimulating Factor-1 Stimulates the Formation of Multimeric Cytosolic Complexes of Signaling Proteins and Cytoskeletal Components in Macrophages* , 1998, The Journal of Biological Chemistry.

[60]  C. Turck,et al.  BLNK: a central linker protein in B cell activation. , 1998, Immunity.

[61]  A. Gilman,et al.  p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13 , 1998 .

[62]  G. Pedraza-Alva,et al.  T Cell Activation through the CD43 Molecule Leads to Vav Tyrosine Phosphorylation and Mitogen-activated Protein Kinase Pathway Activation* , 1998, The Journal of Biological Chemistry.

[63]  R. Xavier,et al.  Membrane compartmentation is required for efficient T cell activation. , 1998, Immunity.

[64]  R. Perona,et al.  Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases* , 1998, The Journal of Biological Chemistry.

[65]  F. Alt,et al.  Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction , 1998, Current Biology.

[66]  K. Tedford,et al.  Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor , 1998, Current Biology.

[67]  D. Fearon,et al.  CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. , 1998, Immunity.

[68]  E. Vellenga,et al.  Signaling through CD5 Activates a Pathway Involving Phosphatidylinositol 3-Kinase, Vav, and Rac1 in Human Mature T Lymphocytes , 1998, Molecular and Cellular Biology.

[69]  M. Schwartz,et al.  Regulation of inositol lipid kinases by Rho and Rac. , 1998, Current opinion in genetics & development.

[70]  M. White,et al.  Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. , 1998, Science.

[71]  D. Bar-Sagi,et al.  Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. , 1998, Science.

[72]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[73]  L. Samelson,et al.  LAT The ZAP-70 Tyrosine Kinase Substrate that Links T Cell Receptor to Cellular Activation , 1998, Cell.

[74]  Mary J. Tharayil,et al.  Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling* , 1998, The Journal of Biological Chemistry.

[75]  A. Weiss,et al.  LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. , 1998, Immunity.

[76]  S. Narumiya,et al.  Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. , 1998, British Journal of Cancer.

[77]  S. Goff,et al.  The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway , 1997, The Journal of experimental medicine.

[78]  S. Sato,et al.  CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[79]  M. Barbacid,et al.  Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation , 1997, Oncogene.

[80]  R. Zamoyska,et al.  A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. , 1997, Immunity.

[81]  L. Van Aelst,et al.  Rho GTPases and signaling networks. , 1997, Genes & development.

[82]  G. Koretzky,et al.  Three domains of SLP-76 are required for its optimal function in a T cell line. , 1997, Journal of immunology.

[83]  T. Mak,et al.  Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. , 1997, Journal of immunology.

[84]  R. Carter,et al.  Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig. , 1997, Journal of immunology.

[85]  P. Leibson Signal transduction during natural killer cell activation: inside the mind of a killer. , 1997, Immunity.

[86]  Jun Wu,et al.  The Vav Binding Site (Y315) in ZAP-70 Is Critical for Antigen Receptor–mediated Signal Transduction , 1997, The Journal of experimental medicine.

[87]  A. Hall,et al.  The GTPase Rho has a critical regulatory role in thymus development , 1997, The EMBO journal.

[88]  G. Radda,et al.  CD40-triggered protein tyrosine phosphorylation on Vav and on phosphatidylinositol 3-kinase correlates with survival of the Ramos-Burkitt lymphoma B cell line. , 1997, Cellular immunology.

[89]  John G. Collard,et al.  Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation , 1997, The Journal of cell biology.

[90]  K. Robbins,et al.  Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway* , 1997, The Journal of Biological Chemistry.

[91]  L. Samelson,et al.  The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. , 1997, Science.

[92]  C. Der,et al.  Lck regulates Vav activation of members of the Rho family of GTPases , 1997, Molecular and cellular biology.

[93]  M. Saraste,et al.  Crystal structure of a calponin homology domain , 1997, Nature Structural Biology.

[94]  O. Yoshida,et al.  Expression of a novel isoform of Vav, Vav-T, containing a single Src homology 3 domain in murine testicular germ cells , 1997, Oncogene.

[95]  C. Rudd,et al.  Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. , 1997, Immunity.

[96]  M. Hibi,et al.  Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin‐6 , 1997, FEBS letters.

[97]  K. Schuebel,et al.  Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product , 1997, Nature.

[98]  P. Hogan,et al.  Transcription factors of the NFAT family: regulation and function. , 1997, Annual review of immunology.

[99]  B. Antonny,et al.  A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains , 1996, Nature.

[100]  T. Mustelin,et al.  Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. , 1996, Immunity.

[101]  F. Romero,et al.  Structure and function of vav. , 1996, Cellular signalling.

[102]  M. Olson,et al.  Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases , 1996, Current Biology.

[103]  J. Rivera,et al.  Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex. , 1996, The Journal of biological chemistry.

[104]  H. Miyazaki,et al.  Functional analysis of the cytoplastic domain of the human Mpl receptor for tyrosine‐phosphorylation of the signaling molecules, proliferation and differentiation , 1996 .

[105]  G. Koretzky,et al.  Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase* , 1996, The Journal of Biological Chemistry.

[106]  A. Chong,et al.  Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase. , 1996, The Biochemical journal.

[107]  L. Tuosto,et al.  p95vav associates with tyrosine-phosphorylated SLP-76 in antigen- stimulated T cells , 1996, The Journal of experimental medicine.

[108]  K. Siminovitch,et al.  Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase , 1996, The Journal of experimental medicine.

[109]  M. Barbacid,et al.  Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. , 1996, Oncogene.

[110]  K. Schuebel,et al.  Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. , 1996, Oncogene.

[111]  J. Wu,et al.  Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. , 1996, Immunity.

[112]  Y. Zheng,et al.  The Dbl family of oncogenes. , 1996, Current opinion in cell biology.

[113]  C. Hofmann,et al.  Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product. , 1996, Experimental hematology.

[114]  J. Brugge,et al.  Thrombin Receptor Activation and Integrin Engagement Stimulate Tyrosine Phosphorylation of the Proto-oncogene Product, p95, in Platelets (*) , 1996, The Journal of Biological Chemistry.

[115]  U. Francke,et al.  Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization , 1996, Cell.

[116]  T. Pawson,et al.  The Tyrosine Phosphatase PTP1C Associates with Vav, Grb2, and mSos1 in Hematopoietic Cells (*) , 1996, The Journal of Biological Chemistry.

[117]  C. Marshall Ras effectors. , 1996, Current opinion in cell biology.

[118]  H. Miyazaki,et al.  Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. , 1996, FEBS letters.

[119]  X. Bustelo,et al.  The VAV family of signal transduction molecules. , 1996, Critical reviews in oncogenesis.

[120]  K. Todokoro,et al.  Thrombopoietin induces activation of at least two distinct signaling pathways , 1995, FEBS letters.

[121]  M. Xia,et al.  Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. , 1995, Blood.

[122]  Y. Yazaki,et al.  TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. , 1995, Biochemical and biophysical research communications.

[123]  M. Saraste,et al.  Does Vav bind to F‐actin through a CH domain? , 1995, FEBS letters.

[124]  J. Camonis,et al.  The proline-rich region of Vav binds to Grb2 and Grb3-3. , 1995, Oncogene.

[125]  S. Schreiber,et al.  Signal transduction in T lymphocytes using a conditional allele of Sos. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[126]  S. Goff,et al.  TPO and IL-3 induce overlapping but distinct protein tyrosine phosphorylation in a myeloid precursor cell line. , 1995, Biochemical and biophysical research communications.

[127]  N. Gusev,et al.  Interaction of smooth muscle calponin with phospholipids , 1995, FEBS letters.

[128]  H. Mano,et al.  Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. , 1995, Oncogene.

[129]  J. Ihle The Janus protein tyrosine kinases in hematopoietic cytokine signaling. , 1995, Seminars in immunology.

[130]  J. Wu,et al.  A functional T-cell receptor signaling pathway is required for p95vav activity , 1995, Molecular and cellular biology.

[131]  R. Prywes,et al.  Serum response factor: transcriptional regulation of genes induced by growth factors and differentiation. , 1995, Biochimica et biophysica acta.

[132]  D. Fearon,et al.  A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. , 1995, Science.

[133]  A. Yuo,et al.  Tyrosine phosphorylation of vav protooncogene product in primary human myelogenous leukemic cells stimulated by granulocyte colony-stimulating factor. , 1995, Biochemical and biophysical research communications.

[134]  D. L. Sokol,et al.  Vav Is Necessary for Prolactin-stimulated Proliferation and Is Translocated into the Nucleus of a T-cell Line (*) , 1995, The Journal of Biological Chemistry.

[135]  J. Kinet,et al.  A Requirement for Syk in the Activation of the Microtubule-associated Protein Kinase/Phospholipase A2 Pathway by FcεR1 Is Not Shared by a G Protein-coupled Receptor (*) , 1995, The Journal of Biological Chemistry.

[136]  K. Yamana,et al.  Interaction of calponin with phospholipids. , 1995, Journal of biochemistry.

[137]  M. White,et al.  Insulin-dependent Tyrosine Phosphorylation of the vav Proto-oncogene Product in Cells of Hematopoietic Origin (*) , 1995, The Journal of Biological Chemistry.

[138]  M. Barbacid,et al.  Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes , 1995, Nature.

[139]  F. Alt,et al.  Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene , 1995, Nature.

[140]  K. Rajewsky,et al.  Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav , 1995, Nature.

[141]  B. Druker,et al.  Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM‐CSF, IL‐3 and steel factor and is constitutively increased by p210BCR/ABL. , 1995, The EMBO journal.

[142]  J. Haines,et al.  Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1 , 1994, Annals of human genetics.

[143]  T. Lebien,et al.  Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. , 1994, The Journal of biological chemistry.

[144]  A. Weiss,et al.  The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. , 1994, The Journal of biological chemistry.

[145]  D. Baltimore,et al.  Binding of Vav to Grb2 through dimerization of Src homology 3 domains. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[146]  S. Orkin,et al.  Hematopoietic development of vav-/- mouse embryonic stem cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[147]  J. Ihle,et al.  Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. , 1994, Blood.

[148]  T. Watanabe,et al.  IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases , 1994, The Journal of experimental medicine.

[149]  R. Stevenson,et al.  Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative Rho Rac guanine nucleotide exchange factor , 1994, Cell.

[150]  C. Der,et al.  Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras , 1994, Molecular and cellular biology.

[151]  G. Mills,et al.  CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[152]  D. Olive,et al.  The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras , 1994, The Journal of experimental medicine.

[153]  A. Altman,et al.  Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[154]  M. Barbacid,et al.  Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor. , 1994, Oncogene.

[155]  B. Druker,et al.  Vav binds to several SH2/SH3 containing proteins in activated lymphocytes. , 1994, Oncogene.

[156]  W. Kuo,et al.  ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. , 1994, Science.

[157]  T. Pawson,et al.  Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase. , 1994, Oncogene.

[158]  T Pawson,et al.  Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav , 1994, Molecular and cellular biology.

[159]  R. Durbin,et al.  2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans , 1994, Nature.

[160]  L. Platanias,et al.  Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells. , 1994, The Journal of biological chemistry.

[161]  R. Treisman Ternary complex factors: growth factor regulated transcriptional activators. , 1994, Current opinion in genetics & development.

[162]  Mark S. Boguski,et al.  Proteins regulating Ras and its relatives , 1993, Nature.

[163]  G. Schieven,et al.  Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. , 1993, The Journal of biological chemistry.

[164]  I. Lemischka,et al.  Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells , 1993, Molecular and cellular biology.

[165]  W. Farrar,et al.  Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck. , 1993, The Biochemical journal.

[166]  M. Barbacid,et al.  Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. , 1992, The Journal of biological chemistry.

[167]  M. Barbacid,et al.  Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells , 1992, Science.

[168]  L. Herzenberg,et al.  Differential development of progenitor activity for three B-cell lineages. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[169]  A. Ullrich,et al.  Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs , 1992, Nature.

[170]  M. Barbacid,et al.  Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates , 1992, Nature.

[171]  J. Cleveland,et al.  Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential , 1991, Molecular and cellular biology.

[172]  M. Barbacid,et al.  Mechanism of activation of the vav protooncogene. , 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[173]  M. Barbacid,et al.  vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. , 1989, The EMBO journal.

[174]  p 95 vav Associates with Tyrosine-phosphorylated SLP-76 in Antigen-st imulated T Cells , 2022 .