The"DownSyndromeCriticalRegion"IsSufficientinthe MouseModeltoConferBehavioral,Neurophysiological,and SynapticPhenotypesCharacteristicofDownSyndrome

Downsyndrome(DS)canbemodeledinmicesegmentallytrisomicformousechromosome16.Ts65DnandTs1CjemousemodelshavebeenusedtostudyDSneurobiologicalphenotypesincludingchangesincognitiveability,inductionoflong-termpotentiation(LTP)inthe fascia dentata (FD), the density and size of dendritic spines, and the structure of synapses. To explore the genetic basis for thesephenotypes,weexaminedTs1RhrmicethataretrisomicforasmallsubsetofthegenestriplicatedinTs65DnandTs1Cjemice.The33trisomicgenesinTs1Rhrrepresenta“DScriticalregion”thatwasoncepredictedtobesufficienttoproducemostDSphenotypes.Wediscoveredsignificantalterationsinanopenfieldtest,anovelobjectrecognitiontestandinaT-mazetask.AsinTs65DnandTs1Cjemice,LTP in FD of Ts1Rhr could be induced only after blocking GABA

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