论文信息 - TR-2007-027 A Case Study in Explorative Functional Data Analysis : Geometrical Features of the Internal Carotid Artery

TR-2007-027 A Case Study in Explorative Functional Data Analysis : Geometrical Features of the Internal Carotid Artery

This pilot study is a product of the AneuRisk Project, a scientific program that aims at evaluating the role of vascular geometry and hemodynamics in the pathogenesis of cerebral aneurysms. By means of functional data analyses, we explore the AneuRisk dataset to highlight the relations between the geometric features of the internal carotid artery, expressed by its radius profile and centerline curvature, and the aneurysm location. After introducing a new similarity index for functional data, we eliminate This research has been carried out within AneuRisk Project, a joint research program involving MOX Laboratory for Modeling and Scientific Computing (Dipartimento di Matematica, Politecnico di Milano), Laboratory of Biological Structures (Dipartimento di Ingegneria Strutturale, Politecnico di Milano), Istituto Mario Negri (Ranica), Ospedale Niguarda Ca’ Granda (Milano), and Ospedale Maggiore Policlinico (Milano). The Project is supported by Fondazione Politecnico di Milano and Siemens-Medical Solutions, Italia. We are especially grateful to Edoardo Boccardi (Ospedale Niguarda Ca’ Granda), who provided the 3D-angiographies and motivated our reaserch by posing fascinating medical questions, and to Luca Antiga and Marina Piccinelli (Istituto Mario Negri), who performed the image reconstructions.

A. Veneziani | P. Secchi | L. M. Sangalli | S. Vantini

[1] C M Putman,et al. Computational fluid dynamics modeling of intracranial aneurysms: effects of parent artery segmentation on intra-aneurysmal hemodynamics. , 2006, AJNR. American journal of neuroradiology.

[2] Hidesato Ito,et al. Flow in curved pipes. , 1987 .

[3] L. Antiga,et al. Computational geometry for patient-specific reconstruction and meshing of blood vessels from MR and CT angiography , 2003, IEEE Transactions on Medical Imaging.

[4] David J. Hand,et al. Discrimination and Classification , 1982 .

[5] K. Takayama,et al. A proposed parent vessel geometry-based categorization of saccular intracranial aneurysms: computational flow dynamics analysis of the risk factors for lesion rupture. , 2005, Journal of neurosurgery.

[6] A. Algra,et al. Prevalence and risk of rupture of intracranial aneurysms: a systematic review. , 1998, Stroke.

[7] H. Meng,et al. Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study. , 2004, Journal of neurosurgery.