Investigation on the regulatory T cells signature and relevant Foxp3/STAT3 axis in esophageal cancer

Regulatory T cells (Tregs) have an important role in accelerating the immunosuppression of tumor. Tregs regulation is a hopeful strategy to improve the dismal prognosis of Esophageal cancer (EC), while its mechanisms have not yet been fully clarified.

[1]  S. Barry,et al.  Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer , 2022, Journal for ImmunoTherapy of Cancer.

[2]  H. Assaf,et al.  Immunohistochemical expression of regulatory T cells (CD4+ CD25+ bright FOXP3+) in pemphigus patients , 2022, Journal of cosmetic dermatology.

[3]  S. Karam,et al.  Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC , 2021, Molecular Therapy.

[4]  S. Bhattacharyya,et al.  Retraction Notice to: FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells. , 2021, Immunity.

[5]  Jia Fan,et al.  Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis , 2021, Journal for ImmunoTherapy of Cancer.

[6]  M. Valkonen,et al.  The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study , 2021, BMC cancer.

[7]  M. Overman,et al.  Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary , 2021, Clinical Cancer Research.

[8]  S. Hirota,et al.  Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer , 2021, AntiCancer Research.

[9]  Jian Cao,et al.  Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment , 2020, Nature Communications.

[10]  Y. Asano,et al.  TLR2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation through Decrease in Regulatory T Cells and Impaired IL-10 Production , 2020, International Journal of Molecular Sciences.

[11]  Shengli Yang,et al.  Eomes promotes esophageal carcinoma progression by recruiting Treg cells through the CCL20‐CCR6 pathway , 2020, Cancer science.

[12]  J. Gu,et al.  Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer , 2020, Journal for ImmunoTherapy of Cancer.

[13]  Reem Saleh,et al.  FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets. , 2020, Cancer letters.

[14]  Qijie Zhao,et al.  Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration , 2020, Theranostics.

[15]  I. Tikhanovich,et al.  The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma , 2020, The Journal of Biological Chemistry.

[16]  Jian Gu,et al.  Decreased Foxp3 and function of Tregs caused immune imbalance and liver injury in patients with autoimmune liver diseases post-liver transplantation , 2020, Annals of translational medicine.

[17]  X. Jia,et al.  CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis , 2020, Molecular Cancer.

[18]  X. Jia,et al.  CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis , 2020, Molecular Cancer.

[19]  L. Fu,et al.  The immune landscape of esophageal cancer , 2019, Cancer communications.

[20]  Beibei Ru,et al.  TISIDB: an integrated repository portal for tumor-immune system interactions , 2019, Bioinform..

[21]  P. Rohani,et al.  Increased number of regulatory T cells in esophageal tissue of patients with eosinophilic esophagitis in comparison to gastro esophageal reflux disease and control groups. , 2019, Allergologia et immunopathologia.

[22]  A. Zfass,et al.  Early Esophageal Cancer: A Gastroenterologist’s Disease , 2019, Digestive Diseases and Sciences.

[23]  Dong Wang,et al.  Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion. , 2019, Cancer letters.

[24]  Jingli Ren,et al.  IL-33 in the tumor microenvironment is associated with the accumulation of FoxP3-positive regulatory T cells in human esophageal carcinomas , 2019, Virchows Archiv.

[25]  C. Perou,et al.  Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression , 2019, Oncogene.

[26]  J. Mock,et al.  Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI. , 2019, JCI insight.

[27]  S. Karam,et al.  STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. , 2019, Journal of the National Cancer Institute.

[28]  Y. Liao,et al.  Tumor Microenvironment Characterization in Gastric Cancer Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures , 2019, Cancer Immunology Research.

[29]  Ruijiang Li,et al.  The Immune Subtypes and Landscape of Squamous Cell Carcinoma , 2019, Clinical Cancer Research.

[30]  R. König,et al.  Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype , 2019, Front. Immunol..

[31]  Lu Zhang,et al.  Immune targets in the tumor microenvironment treated by radiotherapy , 2019, Theranostics.

[32]  O. Andrén,et al.  M2 macrophages and regulatory T cells in lethal prostate cancer , 2018, The Prostate.

[33]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[34]  Zheming Lu,et al.  Immediate and substantial evolution of T-cell repertoire in peripheral blood and tumor microenvironment of patients with esophageal squamous cell carcinoma treated with preoperative chemotherapy , 2018, Carcinogenesis.

[35]  S. Cai,et al.  ImmunoScore Signature: A Prognostic and Predictive Tool in Gastric Cancer , 2016, Annals of surgery.

[36]  Y. Doki,et al.  SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma. , 2017, Cancer research.

[37]  Jianning Zhao,et al.  STAT3 promotes bone fracture healing by enhancing the FOXP3 expression and the suppressive function of regulatory T cells , 2017, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[38]  P. Boutros,et al.  The Immune Microenvironment, Genome‐wide Copy Number Aberrations, and Survival in Mesothelioma , 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[39]  M. Todaro,et al.  Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage , 2017, Cancer Immunology Research.

[40]  M. Muc-Wierzgoń,et al.  Tumor-Associated Macrophages and Regulatory T Cells Infiltration and the Clinical Outcome in Colorectal Cancer , 2017, Archivum Immunologiae et Therapiae Experimentalis.

[41]  S. Fröhling,et al.  PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma , 2017, Oncoimmunology.

[42]  W. Shi,et al.  Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb , 2017, Immunity.

[43]  Damian Szklarczyk,et al.  The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible , 2016, Nucleic Acids Res..

[44]  Chang Xian Li,et al.  CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation. , 2016, Journal of hepatology.

[45]  P. Laurent-Puig,et al.  Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression , 2016, Genome Biology.

[46]  P. Laurent-Puig,et al.  Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression , 2016, Genome Biology.

[47]  Jennifer Hayes Clark,et al.  Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host , 2016, Clinical Cancer Research.

[48]  S. Nomura,et al.  Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma , 2016, Oncotarget.

[49]  N. Gogtay,et al.  Biostatistics Series Module 3: Comparing Groups: Numerical Variables , 2016, Indian journal of dermatology.

[50]  A. Lockhart,et al.  Emerging immunotherapy for the treatment of esophageal cancer , 2016, Expert opinion on investigational drugs.

[51]  Adam J. Bass,et al.  The Tumor Microenvironment in Esophageal Cancer , 2016, Oncogene.

[52]  L. Zitvogel,et al.  Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells , 2016, Oncoimmunology.

[53]  Xuetao Cao,et al.  Immunosuppressive cells in tumor immune escape and metastasis , 2016, Journal of Molecular Medicine.

[54]  A. Azmi,et al.  Immune evasion in cancer: Mechanistic basis and therapeutic strategies. , 2015, Seminars in cancer biology.

[55]  Bin Shang,et al.  Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis , 2015, Scientific Reports.

[56]  T. Whiteside.  The role of regulatory T cells in cancer immunology , 2015, ImmunoTargets and therapy.

[57]  L. Zitvogel,et al.  Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy , 2015, Oncotarget.

[58]  S. Natsugoe,et al.  Interleukin-32 expression and Treg infiltration in esophageal squamous cell carcinoma. , 2015, Anticancer research.

[59]  Mithat Gonen,et al.  Nomograms in oncology: more than meets the eye. , 2015, The Lancet. Oncology.

[60]  Z. Werb,et al.  Balancing the innate immune system in tumor development. , 2015, Trends in cell biology.

[61]  J. Pollard,et al.  Immune cell promotion of metastasis , 2015, Nature Reviews Immunology.

[62]  Davide Heller,et al.  STRING v10: protein–protein interaction networks, integrated over the tree of life , 2014, Nucleic Acids Res..

[63]  刘尧.  Prognostic value of tumorinfiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis , 2015 .

[64]  Wei Wu,et al.  Tumor-derived CD4+CD25+ Tregs inhibit the maturation and antigen-presenting function of dendritic cells. , 2015, Asian Pacific journal of cancer prevention : APJCP.

[65]  X. Zhong,et al.  Dual high expression of STAT3 and cyclinD1 is associated with poor prognosis after curative resection of esophageal squamous cell carcinoma. , 2014, International journal of clinical and experimental pathology.

[66]  C. Benner,et al.  Function of a Foxp3 cis-Element in Protecting Regulatory T Cell Identity , 2014, Cell.

[67]  U. Panzer,et al.  Stat3 programs Th17-specific regulatory T cells to control GN. , 2014, Journal of the American Society of Nephrology : JASN.

[68]  Furhawn A. Shah,et al.  Impact of Inflammation–Metaplasia–Adenocarcinoma Sequence and Inflammatory Microenvironment in Esophageal Carcinogenesis Using Surgical Rat Models , 2014, Annals of Surgical Oncology.

[69]  S. Bhattacharyya,et al.  FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells. , 2013, Immunity.

[70]  Z. Yao,et al.  Immune microenvironment profiles of tumor immune equilibrium and immune escape states of mouse sarcoma. , 2013, Cancer letters.

[71]  Z. Trajanoski,et al.  Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. , 2013, Immunity.

[72]  Y. Liu,et al.  Investigations on the clinical significance of FOXP3 protein expression in cervical oesophageal cancer and the number of FOXP3+ tumour-infiltrating lymphocytes , 2013, The Journal of international medical research.

[73]  J. Luketich,et al.  Oesophageal carcinoma , 2013, The Lancet.

[74]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[75]  S. Raghavan,et al.  Regulatory T cells in gastrointestinal tumors , 2011, Expert review of gastroenterology & hepatology.

[76]  Jingting Jiang,et al.  T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract , 2011, Immunologic research.

[77]  G. Wang,et al.  CD4 + CD25high Regulatory T Cell Numbers and FOXP3 mRNA Expression in Patients with Advanced Esophageal Cancer Before and After Chemotherapy , 2011, Cell Biochemistry and Biophysics.

[78]  H. Du,et al.  Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis. , 2011, Blood.

[79]  Xiao-hua Hou 侯晓华,et al.  Relatively Increased Number of Liver Foxp 3 + Regulatory T Cells against Hepatic Lesions in Murine Lupus , 2011 .

[80]  Xavier Robin,et al.  pROC: an open-source package for R and S+ to analyze and compare ROC curves , 2011, BMC Bioinformatics.

[81]  T. Ha.  The Role of Regulatory T Cells in Cancer , 2009, Immune network.

[82]  Chawnshang Chang,et al.  Immune Suppressive Activity and Lack of T Helper Differentiation Are Differentially Regulated in Natural Regulatory T Cells1 , 2009, The Journal of Immunology.

[83]  C. Drake,et al.  Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. , 2009, Cancer cell.

[84]  S. Tsujitani,et al.  Inverse correlation between NKG2D expression on CD8+ T cells and the frequency of CD4+CD25+ regulatory T cells in patients with esophageal cancer. , 2009, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[85]  N. Zeps,et al.  Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[86]  D. Unutmaz,et al.  The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer. , 2009, Advances in experimental medicine and biology.

[87]  T. Whiteside.  The tumor microenvironment and its role in promoting tumor growth , 2008, Oncogene.

[88]  Markus Ringnér,et al.  What is principal component analysis? , 2008, Nature Biotechnology.

[89]  P. Rohrlich,et al.  Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity1 , 2007, The Journal of Immunology.

[90]  Cheng Li,et al.  Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.

[91]  J. Ritz,et al.  IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. , 2006, Blood.

[92]  M. Beyer,et al.  Regulatory T cells in cancer. , 2006, Blood.

[93]  M. J. van de Vijver,et al.  Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. , 2006, Journal of the National Cancer Institute.

[94]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[95]  George Coukos,et al.  Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival , 2004, Nature Medicine.

[96]  Benjamin M. Bolstad,et al.  affy - analysis of Affymetrix GeneChip data at the probe level , 2004, Bioinform..