Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization

[1]  Zhihong Zhang,et al.  Peptide‐Decorated Artificial Erythrocyte Microvesicles Endowed with Lymph Node Targeting Function for Drug Delivery , 2023, Advanced Therapeutics.

[2]  Yinhong Song,et al.  Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis , 2023, Journal of Nanobiotechnology.

[3]  Junbai Li,et al.  Self-assembling nanoarchitectonics of size-controllable celastrol nanoparticles for efficient cancer chemotherapy with reduced systemic toxicity. , 2022, Journal of colloid and interface science.

[4]  Huanhuan Zhu,et al.  Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling , 2022, Immunopharmacology and immunotoxicology.

[5]  Hao Liu,et al.  Insights into the Role of Macrophage Polarization in the Pathogenesis of Osteoporosis , 2022, Oxidative medicine and cellular longevity.

[6]  Zhilong Jiang,et al.  Native Endophytes of Tripterygium wilfordii-Mediated Biotransformation Reduces Toxicity of Celastrol , 2022, Frontiers in Microbiology.

[7]  Q. Tan,et al.  Engineered extracellular vesicles: potentials in cancer combination therapy , 2022, Journal of Nanobiotechnology.

[8]  Songtao Li,et al.  Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways , 2022, Frontiers in Pharmacology.

[9]  Cheng Wang,et al.  Macrophage Polarization and Its Role in Liver Disease , 2021, Frontiers in Immunology.

[10]  H. Jaeschke,et al.  Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice , 2021, Archives of Toxicology.

[11]  H. Jaeschke,et al.  Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products. , 2021, Toxicology letters.

[12]  G. Adzika,et al.  Estrogen Attenuates Chronic Stress-Induced Cardiomyopathy by Adaptively Regulating Macrophage Polarizations via β2-Adrenergic Receptor Modulation , 2021, Frontiers in Cell and Developmental Biology.

[13]  Xuyang Dai,et al.  The Dual Role of Immune Response in Acetaminophen Hepatotoxicity: Implication for Immune Pharmacological Targets. , 2021, Toxicology letters.

[14]  Weifeng Huang,et al.  Mitochondrial stress response in drug-induced liver injury , 2021, Molecular Biology Reports.

[15]  J. Dear,et al.  Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury , 2021, Science Translational Medicine.

[16]  C. Zhang,et al.  Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration. , 2021, Journal of controlled release : official journal of the Controlled Release Society.

[17]  M. Aghajan,et al.  Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity , 2021, The Journal of biological chemistry.

[18]  Yang Yang,et al.  Aging erythrocyte membranes as biomimetic nanometer carriers of liver-targeting chromium poisoning treatment , 2021, Drug delivery.

[19]  Qiang Xu,et al.  Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice , 2020, Acta pharmaceutica Sinica. B.

[20]  Jianli Wang,et al.  Extracellular vesicles: Natural liver‐accumulating drug delivery vehicles for the treatment of liver diseases , 2020, Journal of extracellular vesicles.

[21]  J. Yamate,et al.  Acetaminophen-Induced Rat Hepatotoxicity Based on M1/M2-Macrophage Polarization, in Possible Relation to Damage-Associated Molecular Patterns and Autophagy , 2020, International journal of molecular sciences.

[22]  Guihua Fang,et al.  Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases. , 2020, Journal of materials chemistry. B.

[23]  Yong Wang,et al.  Inflammation-targeted celastrol nanodrug attenuates collagen-induced arthritis through NF-κB and Notch1 pathways. , 2020, Nano letters.

[24]  A. Piras,et al.  Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy. , 2020, Journal of controlled release : official journal of the Controlled Release Society.

[25]  C. Stephens,et al.  Drug induced liver injury: an update , 2020, Archives of Toxicology.

[26]  V. Pillay,et al.  Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma , 2020, International Journal of Polymeric Materials and Polymeric Biomaterials.

[27]  F. Gonzalez,et al.  Celastrol ameliorates acute liver injury through modulation of PPARα. , 2020, Biochemical pharmacology.

[28]  H. Jaeschke,et al.  Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. , 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[29]  Taolue Wu,et al.  Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis , 2020, Journal of Nanobiotechnology.

[30]  P. Watkins,et al.  Drug-induced liver injury , 2019, Nature Reviews Disease Primers.

[31]  Z. Beck,et al.  Particle size analyses of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technology. , 2019, International journal of pharmaceutics.

[32]  Sharan Bobbala,et al.  Celastrol-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis. , 2019, Biomaterials Science.

[33]  B. A. David,et al.  SOCS2 Is Critical for the Balancing of Immune Response and Oxidate Stress Protecting Against Acetaminophen-Induced Acute Liver Injury , 2019, Front. Immunol..

[34]  Y. Iwakura,et al.  Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity , 2018, Cellular & Molecular Immunology.

[35]  Jintang Xia,et al.  Hydrogen sulfide protects against acetaminophen‐induced acute liver injury by inhibiting apoptosis via the JNK/MAPK signaling pathway , 2018, Journal of cellular biochemistry.

[36]  M. Kara,et al.  Celastrol ameliorates acetaminophen-induced oxidative stress and cytotoxicity in HepG2 cells , 2018, Human & experimental toxicology.

[37]  H. Jaeschke,et al.  Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity , 2018, Current Pharmacology Reports.

[38]  Limin Xu,et al.  Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization , 2018, Journal of Neuroinflammation.

[39]  Limin Xu,et al.  Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization , 2018, Journal of Neuroinflammation.

[40]  Chao Wang,et al.  Red Blood Cells as Smart Delivery Systems. , 2018, Bioconjugate chemistry.

[41]  Zhen Gu,et al.  Red Blood Cells for Drug Delivery , 2017 .

[42]  Yumeng Guo,et al.  Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways , 2017, Aging.

[43]  M. E. Shaker,et al.  Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G. , 2017, Toxicology letters.

[44]  Y. Iwakura,et al.  Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity , 2017, Cellular & Molecular Immunology.

[45]  H. Jaeschke,et al.  Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. , 2017, Journal of hepatology.

[46]  H. Jaeschke Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients , 2015, Digestive Diseases.

[47]  W. M. Leevy,et al.  Hepatic DNA deposition drives drug‐induced liver injury and inflammation in mice , 2015, Hepatology.

[48]  Seon-Mi Yu,et al.  The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes , 2014, International journal of molecular medicine.

[49]  F. Tacke,et al.  Immune mechanisms in acetaminophen-induced acute liver failure. , 2014, Hepatobiliary surgery and nutrition.

[50]  D. C. Cara,et al.  Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure , 2012, Hepatology.

[51]  Yang Yang,et al.  Peptide-MHC-based nanovaccines for the treatment of autoimmunity: a “one size fits all” approach? , 2011, Journal of Molecular Medicine.

[52]  A. Xu,et al.  Celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils , 2017 .