Singular case of acanthosis nigricans

© BMJ Publishing Group Limited 2021. No commercial reuse. See rights and permissions. Published by BMJ. DESCRIPTION A 12yearold Caucasian girl was referenced to a paediatric endocrinology consultation for extensive acanthosis nigricans (AN), hirsutism and severe obesity (Body Mass Index (BMI): 37.5 kg/m, zscore 3.57). She had a normal psychomotor development. Her mother and her maternal grandfather had obesity. Examination revealed Tanner 5 with deep voice, hirsutism (Ferriman and Gallwey score 14), abdominal and lumbar striae, and severe lesions of AN involving the neck, armpits, intermammary cleft and inframammary area (Burke score 11/14) (figure 1). Biochemical evaluation revealed dyslipidaemia (triglycerides 213 mg/dL), insulin resistance (IR) (insulin 43.5 μUI/mL, HOMAIR 10.2), high testosterone (74 ng/dL) and low sex hormonebinding globulin (8 nmol/L). She had menarche and there was no oligomenorrhea. Congenital adrenal hyperplasia and hypercortisolism were excluded. Oral glucose tolerance test was normal. In order to screen for a virilising tumour, an abdominal MRI was performed, showing regular adrenal glands but large ovaries (right ovary 27 mm and left ovary 29 mm) with multiple millimetric cysts related to polycystic ovary syndrome (POS). Treatment comprised dietary and physical activity counselling, as well as a gradual treatment with metformin, pioglitazone, spironolactone and oral combined hormonal contraceptive. After 3 years of followup, although maintaining a BMI zscore of 3.57, there was partial regression of AN (figure 2) and improvement in the biochemical evaluation: absence of dyslipidaemia and lower testosterone (50.84 ng/dL). IR has worsened (insulin 51.9 μUI/mL, HOMAIR 12.4), which may be due to the absence of weight loss and to pubertal physiological IR. AN is characterised by dark and thickened skin, symmetrically distributed more frequently on the neck, axillae and groin folds. AN is usually associated with obesity, POS, type 2 diabetes, monogenic causes of IR and malignancy (particularly, gastric carcinoma, Wilm’s tumour and virilising tumours). Paraneoplastic syndromes are often associated with severe AN. In AN related to obesity, increased insulin activates keratinocyte insulinlike growth factor (IGF) receptors, particularly IGF-1. At high concentrations, insulin may displace IGF-1 from IGFbinding proteins. Increased circulating IGF leads to keratinocyte and dermal fibroblast proliferation. Among patients with POS, AN is associated with higher free testosterone levels, which may be explained by the association with hyperinsulinaemia, which can promote ovarian thecal androgen secretion and inhibit hepatic synthesis of sex hormonebinding globulin, as in the case of our patient. AN is a manageable condition, however, the complete reversion of the lesions is difficult to achieve. Although weight reduction is acknowledged as the most efficient strategy to tackle AN, this report suggests that metformin and pioglitazone should be considered in order to improve insulin sensitivity and endocrine and metabolic indices, which may have a visible impact on AN extension. 4 In this case, despite the lack of hyperandrogenic signs (acne, alopecia or oligomenorrhea), it was imperative to exclude adrenal and abdominal malignancies. This report highlights a rare case of severe