Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

[1]  R. Dantzer,et al.  CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression , 2009, Molecular Psychiatry.

[2]  Alessandro Filosa,et al.  Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport , 2009, Nature Neuroscience.

[3]  J. Uslaner,et al.  Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus , 2009, Neuropharmacology.

[4]  P. Klivényi,et al.  The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection , 2009, Journal of the Neurological Sciences.

[5]  S. Itohara,et al.  Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1 , 2009, Neuroscience.

[6]  T. Comery,et al.  Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders , 2009, Journal of Pharmacology and Experimental Therapeutics.

[7]  R. Schwarcz,et al.  Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum , 2009, Neuroscience.

[8]  R. Schwarcz,et al.  Astrocyte‐derived kynurenic acid modulates basal and evoked cortical acetylcholine release , 2009, The European journal of neuroscience.

[9]  Tao Cai,et al.  Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III , 2008, Molecular and Cellular Biology.

[10]  E. Cherubini,et al.  The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus , 2008, Neuropharmacology.

[11]  K. Hashimoto,et al.  d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats , 2008, Behavioural Brain Research.

[12]  Alison L. Barth,et al.  Ongoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex , 2008, Science.

[13]  J. Lieberman,et al.  Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia. , 2007, Schizophrenia bulletin.

[14]  R. Schwarcz,et al.  Mitochondrial aspartate aminotransferase: a third kynurenate‐producing enzyme in the mammalian brain , 2007, Journal of neurochemistry.

[15]  R. Schwarcz,et al.  Competitive Antagonism between the Nicotinic Allosteric Potentiating Ligand Galantamine and Kynurenic Acid at α7* Nicotinic Receptors , 2007, Journal of Pharmacology and Experimental Therapeutics.

[16]  D. Bucci,et al.  Elevations of endogenous kynurenic acid produce spatial working memory deficits. , 2007, Schizophrenia bulletin.

[17]  J. Coyle,et al.  Endogenous N‐acetylaspartylglutamate reduced NMDA receptor‐dependent current neurotransmission in the CA1 area of the hippocampus 1 , 2007, Journal of neurochemistry.

[18]  M. Richard Theories of Hippocampal Function , 2006 .

[19]  T. Bliss,et al.  The Hippocampus Book , 2006 .

[20]  M. Raiteri,et al.  Modulation of the function of presynaptic α7 and non‐α7 nicotinic receptors by the tryptophan metabolites, 5‐hydroxyindole and kynurenate in mouse brain , 2006 .

[21]  G. Lynch,et al.  Ampakines and the threefold path to cognitive enhancement , 2006, Trends in Neurosciences.

[22]  D. Bucci,et al.  Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding , 2006, Behavioural Brain Research.

[23]  Su-Jane Wang,et al.  Facilitation of glutamate release by nicotine involves the activation of a Ca2+/calmodulin signaling pathway in rat prefrontal cortex nerve terminals , 2006, Synapse.

[24]  R. Schwarcz,et al.  Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)‐4‐(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor , 2006, ChemMedChem.

[25]  J. Rawlins,et al.  The drugs don’t work—or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory , 2006, Psychopharmacology.

[26]  T. Robbins,et al.  Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition , 2006, Trends in pharmacological sciences.

[27]  F. Joseph McClernon,et al.  Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization , 2006, Psychopharmacology.

[28]  R. Schwarcz,et al.  Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease , 2006, Experimental Neurology.

[29]  F. Leisch,et al.  Strain-dependent regulation of plasticity-related proteins in the mouse hippocampus , 2005, Behavioural Brain Research.

[30]  R. Schwarcz,et al.  Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum , 2005, Journal of neurochemistry.

[31]  R. Palmiter,et al.  Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards. , 2005, Behavioral neuroscience.

[32]  P. Nguyen,et al.  Multidisciplinary approaches for investigating the mechanisms of hippocampus-dependent memory: a focus on inbred mouse strains , 2004, Neuroscience & Biobehavioral Reviews.

[33]  M. Geyer,et al.  Endogenous kynurenic acid disrupts prepulse inhibition , 2004, Biological Psychiatry.

[34]  S. Dunnett,et al.  Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests , 2004, Genes, brain, and behavior.

[35]  R. Schwarcz,et al.  Biochemical and Phenotypic Abnormalities in Kynurenine Aminotransferase II-Deficient Mice , 2004, Molecular and Cellular Biology.

[36]  S. Dunnett,et al.  Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests , 2004, Genes, brain, and behavior.

[37]  L. Clerkin,et al.  Micromolar Brain Levels of Kynurenic Acid are Associated with a Disruption of Auditory Sensory Gating in the Rat , 2003, Neuropsychopharmacology.

[38]  R. Schwarcz,et al.  Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities , 2002, Journal of Pharmacology and Experimental Therapeutics.

[39]  K. Blennow,et al.  Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia , 2001, Neuroscience Letters.

[40]  A. Fine,et al.  Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus , 2001, The Journal of Neuroscience.

[41]  R. Schwarcz,et al.  Increased cortical kynurenate content in schizophrenia , 2001, Biological Psychiatry.

[42]  R. Schwarcz,et al.  The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications , 2001, The Journal of Neuroscience.

[43]  M. Raiteri,et al.  Presynaptic kynurenate‐sensitive receptors inhibit glutamate release , 2001, The European journal of neuroscience.

[44]  N. Barazangi,et al.  Facilitation of glutamatergic neurotransmission by presynaptic nicotinic acetylcholine receptors , 2000, Neuropharmacology.

[45]  M. Raiteri,et al.  The "kynurenate test", a biochemical assay for putative cognition enhancers. , 1997, The Journal of pharmacology and experimental therapeutics.

[46]  R. Gray,et al.  Hippocampal synaptic transmission enhanced by low concentrations of nicotine , 1996, Nature.

[47]  R. Nicoll,et al.  Ca2+ Signaling Requirements for Long-Term Depression in the Hippocampus , 1996, Neuron.

[48]  T. Bliss,et al.  Long-term potentiation and glutamate release in the dentate gyrus: links to spatial learning , 1995, Behavioural Brain Research.

[49]  H. R. Zielke,et al.  Cerebral Metabolic Compartmentation as Revealed by Nuclear Magnetic Resonance Analysis of D‐[1‐13C]Glucose Metabolism , 1993, Journal of neurochemistry.

[50]  M. Buhot,et al.  Object exploration and reactions to spatial and nonspatial changes in hooded rats following damage to parietal cortex or hippocampal formation. , 1992, Behavioral neuroscience.

[51]  G. Lynch,et al.  A Glycine Site Associated with N‐Methyl‐d‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists , 1989, Journal of neurochemistry.

[52]  R. Schwarcz,et al.  Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid , 1984, Neuroscience Letters.

[53]  T. Stone,et al.  An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid , 1982, Brain Research.

[54]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[55]  E. Albuquerque,et al.  Mammalian nicotinic acetylcholine receptors: from structure to function. , 2009, Physiological reviews.

[56]  R. Schwarcz,et al.  The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex , 2009, Journal of Molecular Neuroscience.

[57]  R. Schwarcz,et al.  Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry , 2007, Glia.

[58]  J. Macdonald,et al.  Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors. , 2006, Critical reviews in neurobiology.

[59]  M. Raiteri,et al.  Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. , 2006, British journal of pharmacology.

[60]  W. Hauber,et al.  Effects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasks , 2005, Journal of Neural Transmission / General Section JNT.

[61]  P. Kelly,et al.  Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice , 2005, Psychopharmacology.

[62]  R. Schwarcz,et al.  Kynurenate production by cultured human astrocytes , 2003, Journal of Neural Transmission.

[63]  R. Schwarcz,et al.  The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. , 2001, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[64]  C. Cotman,et al.  The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. , 1989, Annual review of pharmacology and toxicology.