Integrative genomic profiling of hepatocellular adeno- mas identify mutational processes involved in malignant transformation

Integrative genomic profiling of hepatocellular adenomas identify mutational processes involved in malignant transformation Camilla Pilati1, Jean-Charles Nault1, Eric Letouzé2, Sandrine Imbeaud1, Maxime Mallet1, Anaïs Boulai1, Julien Calderaro1,3, Charles Balabaud6, Benoit Terris4, Valerie Paradis5, Jean Yves Scoazec7, Anne de Muret10, Catherine Guettier8, Paulette BioulacSage6, Fabien Calvo9, Jessica Zucman-Rossi1; 1Génomique fonctionnelle des tumeurs solides, INSERM U674, Paris, France; 2Programme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France; 3Department of Pathology, CHU Henri Mondor, Créteil, France; 4Department of Pathology, Cochin Hospital, Paris, France; 5Department of Pathology, Beaujon Hospital, Paris, France; 6Department of Pathology, Pellegrin Hospital, Bordeaux, France; 7Department of Pathology, Edouard Herriot Hospital, Lyon, France; 8Department of Pathology, CHU Bicêtre, Le Kremlin-Bicêtre, France; 9Institut National du Cancer, INCa, Boulogne, France; 10Department of Pathology, Trousseau Hospital, Tours, France