Spaceflight and development of immune responses.

The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. Additional controls were in standard housing. The effects of the flight on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in flown dams but was not inhibited in cells from their pups. Interferon-gamma production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone marrow cells to colony-stimulating factor showed a trend toward inhibition after spaceflight in dams, but the response of fetus and pup liver cells was not inhibited. Total serum IgG was not affected by spaceflight. None of the examined immune parameters that were altered in rat dams after spaceflight was found to be altered in their offspring.

[1]  D. R. Morrison,et al.  Cytokine secretion by immune cells in space , 1992, Journal of leukocyte biology.

[2]  C. Hodson,et al.  Effects of space flight on ovarian-hypophyseal function in postpartum rats. , 1997, Journal of Reproduction and Fertility.

[3]  A T Ichiki,et al.  Effects of spaceflight on rat peripheral blood leukocytes and bone marrow progenitor cells , 1996, Journal of leukocyte biology.

[4]  C. Sams,et al.  The role of psychoneuroendocrine factors on spaceflight‐induced immunological alterations , 1993, Journal of leukocyte biology.

[5]  G Sonnenfeld,et al.  The role of cytokines in immune changes induced by spaceflight , 1993, Journal of leukocyte biology.

[6]  G R Taylor,et al.  Effects of spaceflight on levels and activity of immune cells. , 1990, Aviation, space, and environmental medicine.

[7]  R. Ader,et al.  Psychoneuroimmunology, 2nd ed. , 1991 .

[8]  M. Ghandour,et al.  Effects of an 11-day spaceflight on the choroid plexus of developing rats. , 1997, Brain research. Developmental brain research.

[9]  S. Segal,et al.  The ontogeny of antigen-specific T cells , 1975, The Journal of experimental medicine.

[10]  I. V. Konstantinova,et al.  The immune system in space and other extreme conditions , 1991 .

[11]  I V Konstantinova,et al.  Effect of spaceflight on lymphocyte proliferation and interleukin-2 production. , 1992, Journal of applied physiology.

[12]  Z. Allebban,et al.  Effects of spaceflight on the number of rat peripheral blood leukocytes and lymphocyte subsets , 1994, Journal of leukocyte biology.

[13]  G R Taylor,et al.  Effect of space flight on cytokine production and other immunologic parameters of rhesus monkeys. , 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[14]  G R Taylor,et al.  Spaceflight alters immune cell function and distribution. , 1992, Journal of applied physiology.

[15]  A. Mastro,et al.  Variable lymphocyte responses in rats after space flight. , 1992, Experimental cell research.

[16]  J. Miquel,et al.  Gravity effects on reproduction, development, and aging. , 1991, Advances in space biology and medicine.

[17]  I V Konstantinova,et al.  Immune changes during long‐duration missions , 1993, Journal of leukocyte biology.

[18]  G Sonnenfeld,et al.  Changes in the immune system during and after spaceflight. , 1997, Advances in space biology and medicine.

[19]  G R Taylor,et al.  Effect of spaceflight on natural killer cell activity. , 1992, Journal of applied physiology.

[20]  G. Sonnenfeld,et al.  Effect of SLS-2 spaceflight on immunologic parameters of rats. , 1996, Journal of applied physiology.

[21]  R. Ader,et al.  The effects of handling on antibody production, mitogen responses, spleen cell number, and lymphocyte subpopulations. , 1990, Life sciences.

[22]  G R Taylor,et al.  In vivo testing confirms a blunting of the human cell‐mediated immune mechanism during space flight , 1992, Journal of leukocyte biology.

[23]  S. Chou,et al.  Characterization of the Effect of 2-Deoxy-d-Glucose(2-DG) on the Immune System , 1996, Brain, Behavior, and Immunity.

[24]  G. Taylor.  Immune changes during short‐duration missions , 1993, Journal of leukocyte biology.

[25]  D. Rowlands,et al.  Development of humoral immunity in lethally irradiated mice reconstituted with fetal liver. , 1974, Journal of immunology.

[26]  L S Neale,et al.  Alteration in human mononuclear leucocytes following space flight. , 1992, Immunology.

[27]  G Sonnenfeld,et al.  Influence of spaceflight on the production of interleukin-3 and interleukin-6 by rat spleen and thymus cells. , 1995, Journal of applied physiology.

[28]  A Cogoli,et al.  Cellular immunity in cosmonauts during long duration spaceflight on board the orbital MIR station. , 1994, Aviation, space, and environmental medicine.

[29]  E W Voss.  Prolonged weightlessness and humoral immunity. , 1984, Science.

[30]  A. Silverstein.  From the forehead of Zeus: The ontogeny of the immune response , 1995, Eye.

[31]  M. Rykova,et al.  Results of space experiment program "Interferon". , 1984, Acta astronautica.

[32]  A D Mandel,et al.  Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle. , 1987, Aviation, space, and environmental medicine.