Cerebral microvascular pathology in aging and Alzheimer's disease

[1]  E. Peskind,et al.  Alzheimer's disease and related disorders. , 2001, The Medical clinics of North America.

[2]  P. Luiten,et al.  Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain , 2001, Neurobiology of Aging.

[3]  E. Fuchs,et al.  Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey , 2000, Acta Neuropathologica.

[4]  R. Vos,et al.  Pathological features of cerebral cortical capillaries are doubled in Alzheimer’s disease and Parkinson’s disease , 2000, Acta Neuropathologica.

[5]  M. Rafii,et al.  Agrin and microvascular damage in Alzheimer's disease , 2000, Neurobiology of Aging.

[6]  M. Breteler.  Vascular Involvement in Cognitive Decline and Dementia: Epidemiologic Evidence from the Rotterdam Study and the Rotterdam Scan Study , 2000, Annals of the New York Academy of Sciences.

[7]  P. Luiten,et al.  Similar Ultrastructural Breakdown of Cerebrocortical Capillaries in Alzheimer's Disease, Parkinson's Disease, and Experimental Hypertension: What is the Functional Link? , 2000, Annals of the New York Academy of Sciences.

[8]  T. Town,et al.  Aβ Vasoactivity: An Inflammatory Reaction , 2000 .

[9]  P. Peruzzi,et al.  Differentiated Cerebrovascular Effects of Physostigmine and Tacrine in Cortical Areas Deafferented from the Nucleus Basalis Magnocellularis Suggest Involvement of Basalocortical Projections to Microvessels , 2000, Annals of the New York Academy of Sciences.

[10]  J. Wegiel,et al.  Role of Perivascular Cells and Myocytes in Vascular Amyloidosis , 2000, Annals of the New York Academy of Sciences.

[11]  W. Thomas,et al.  Cellular mechanisms of CNS pericytes , 2000, Brain Research Bulletin.

[12]  Paul E. Gilbert,et al.  Testing neural network models of memory with behavioral experiments , 2000, Current Opinion in Neurobiology.

[13]  M. Jucker,et al.  Mechanisms of Cerebrovascular Amyloid Deposition: Lessons from Mouse Models , 2000, Annals of the New York Academy of Sciences.

[14]  R. Vos,et al.  Are Alzheimer’s disease, hypertension, and cerebrocapillary damage related?☆ , 2000, Neurobiology of Aging.

[15]  B. Pappas,et al.  Cleavage of amyloid precursor protein elicited by chronic cerebral hypoperfusion , 2000, Neurobiology of Aging.

[16]  J. Meyer,et al.  Distinguishing patients with senile dementia of Alzheimer type and normal elderly subjects utilizing xenon CT-CBF and multivariate analysis. , 2000, The Keio journal of medicine.

[17]  R. Bryan,et al.  Mechanism of endothelin-1-induced contraction in rabbit basilar artery. , 2000, Stroke.

[18]  L. Smith,et al.  Effects of recombinant eNOS gene expression on reactivity of small cerebral arteries. , 2000, American journal of physiology. Heart and circulatory physiology.

[19]  C. Patlak,et al.  In Vitro Evidence That β‐Amyloid Peptide 1–40 Diffuses Across the Blood–Brain Barrier and Affects Its Permeability , 2000, Journal of neuropathology and experimental neurology.

[20]  L. Mucke,et al.  Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. , 2000, The American journal of pathology.

[21]  R. Mrowka,et al.  Blood pressure control in eNOS knock-out mice: comparison with other species under NO blockade. , 2000, Acta physiologica Scandinavica.

[22]  D. Hirst,et al.  Retinal pericytes control expression of nitric oxide synthase and endothelin-1 in microvascular endothelial cells. , 2000, Microvascular research.

[23]  R. Roos,et al.  Ultrastructural evidence of early non-fibrillar Aβ42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type , 1999, Acta Neuropathologica.

[24]  P. Wesseling,et al.  Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain. , 1999, The American journal of pathology.

[25]  W. Thomas,et al.  Brain macrophages: on the role of pericytes and perivascular cells , 1999, Brain Research Reviews.

[26]  W. Mali,et al.  Circle of Willis collateral flow investigated by magnetic resonance angiography. , 1999, Stroke.

[27]  A. Wandinger-Ness,et al.  Cablin: a novel protein of the capillary basal lamina. , 1999, American journal of physiology. Heart and circulatory physiology.

[28]  D. Webb,et al.  The role of endothelin-1 in pressure autoregulation of cerebral blood flow in rats , 1999, Intensive Care Medicine.

[29]  E. Mackenzie,et al.  Neurochemical stimulation of the rat substantia innominata increases cerebral blood flow (but not glucose use) through the parallel activation of cholinergic and non-cholinergic pathways , 1999, Brain Research.

[30]  L. Guoqing,et al.  Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells. , 1999 .

[31]  I. Romero,et al.  Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier. , 1999, Free radical biology & medicine.

[32]  N C Andreasen,et al.  Age-related changes in regional cerebral blood flow among young to mid-life adults. , 1999, Neuroreport.

[33]  R. Busse,et al.  Signal transduction of eNOS activation. , 1999, Cardiovascular research.

[34]  G. Crelier,et al.  Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Villemure,et al.  Multiple Microvascular and Astroglial 5-Hydroxytryptamine Receptor Subtypes in Human Brain: Molecular and Pharmacologic Characterization , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[36]  X. Tong,et al.  Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease , 1999, Neuroscience.

[37]  P. Luiten,et al.  Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory , 1999, Progress in Neurobiology.

[38]  B B Biswal,et al.  Effect of hemodilution on RBC velocity, supply rate, and hematocrit in the cerebral capillary network. , 1999, Journal of applied physiology.

[39]  A Olivier,et al.  Functional Acetylcholine Muscarinic Receptor Subtypes in Human Brain Microcirculation: Identification and Cellular Localization , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[40]  J. Arnal,et al.  Endothelium-derived nitric oxide and vascular physiology and pathology , 1999, Cellular and Molecular Life Sciences CMLS.

[41]  J. C. Torre,et al.  Critical threshold cerebral hypoperfusion causes Alzheimer’s disease? , 1999, Acta Neuropathologica.

[42]  J. C. Torre,et al.  Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment , 1999, Neuroscience.

[43]  G. Mchedlishvili,et al.  Microcirculatory Stasis Induced by Hemorheological Disorders: Further Evidence , 1999, Microcirculation.

[44]  D. Selkoe,et al.  Receptor-Mediated Transport of Human Amyloid β-Protein 1–40 and 1–42 at the Blood–Brain Barrier , 1999, Neurobiology of Disease.

[45]  V. Casagrande,et al.  Endothelial nitric oxide synthetase (eNOS) in astrocytes: Another source of nitric oxide in neocortex , 1999, Glia.

[46]  R. Roos,et al.  Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls , 1999, Brain Research.

[47]  M. Emmerling,et al.  High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease. , 1999, Biochemical and biophysical research communications.

[48]  R. Kisilevsky,et al.  Basement membranes, microfibrils and β amyloid fibrillogenesis in Alzheimer's disease: high resolution ultrastructural findings , 1999, Brain Research Reviews.

[49]  S. Kinomura,et al.  Tc-99m HMPAO SPECT in the evaluation of Alzheimer’s disease: correlation between neuropsychiatric evaluation and CBF images , 1999, Journal of neurology, neurosurgery, and psychiatry.

[50]  S. Love.  Oxidative Stress in Brain Ischemia , 1999, Brain pathology.

[51]  H. Vinters,et al.  Amyloid beta precursor protein-mRNA is expressed throughout cerebral vessel walls. , 1999, Brain research.

[52]  J. Krejza,et al.  Transcranial color Doppler sonography of basal cerebral arteries in 182 healthy subjects: age and sex variability and normal reference values for blood flow parameters. , 1999, AJR. American journal of roentgenology.

[53]  R. Vos,et al.  Cerebral microvascular breakdown in Alzheimer's disease and in experimental cerebral hypoperfusion , 1999 .

[54]  G. Liu,et al.  Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells. , 1999, Life sciences.

[55]  L. Rubin,et al.  The cell biology of the blood-brain barrier. , 1999, Annual review of neuroscience.

[56]  H. Eichenbaum,et al.  Hippocampus as a memory map: Synaptic plasticity and memory encoding by hippocampal neurons , 1999, Hippocampus.

[57]  D. Heistad,et al.  Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[58]  Kinzo Matsumoto,et al.  Chronic cerebral hypoperfusion-induced neuropathological changes in rats. , 1998, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.

[59]  V. Seifert,et al.  Endothelin and subarachnoid hemorrhage: an overview. , 1998, Neurosurgery.

[60]  C. B. Smith,et al.  Glucose Transporter Expression in Brain: Relationship to Cerebral Glucose Utilization , 1998, Developmental Neuroscience.

[61]  María Angeles Peinado,et al.  Quantitative and ultrastructural changes in glia and pericytes in the parietal cortex of the aging rat , 1998, Microscopy research and technique.

[62]  P. Dore‐Duffy,et al.  Role of the CNS microvascular pericyte in the blood‐brain barrier , 1998, Journal of neuroscience research.

[63]  B. Penke,et al.  β-Amyloid (1–42) peptide impairs blood-brain barrier function after intracarotid infusion in rats , 1998, Neuroscience Letters.

[64]  Yu-Min Kuo,et al.  Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. , 1998, The American journal of pathology.

[65]  M. Morioka,et al.  Pathophysiology and treatment of cerebral ischemia. , 1998, The journal of medical investigation : JMI.

[66]  J. Baron,et al.  The neural substrates of memory systems impairment in Alzheimer's disease. A PET study of resting brain glucose utilization. , 1998, Brain : a journal of neurology.

[67]  K. Fukuchi,et al.  Alzheimer's disease and heparan sulfate proteoglycan. , 1998, Frontiers in bioscience : a journal and virtual library.

[68]  U. Dirnagl,et al.  Chemiluminescence detection of nitric oxide production from rat cerebral cortical endothelial cells in culture. , 1998, Brain research. Brain research protocols.

[69]  K. Ishii,et al.  Paradoxical hippocampus perfusion in mild-to-moderate Alzheimer's disease. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[70]  B. Pappas,et al.  Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment , 1998, Neuroreport.

[71]  J. Bading,et al.  Cerebrovascular Accumulation and Increased Blood‐Brain Barrier Permeability to Circulating Alzheimer's Amyloid β Peptide in Aged Squirrel Monkey with Cerebral Amyloid Angiopathy , 1998, Journal of neurochemistry.

[72]  B. Landeau,et al.  Effects of Healthy Aging on the Regional Cerebral Metabolic Rate of Glucose Assessed with Statistical Parametric Mapping , 1996, NeuroImage.

[73]  R. Boado.  Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors. , 1998, Journal of neural transmission. Supplementum.

[74]  P. Whitehouse.  The cholinergic deficit in Alzheimer's disease. , 1998, The Journal of clinical psychiatry.

[75]  A. Coppens,et al.  Cholinergic Neurotransmission Has Different Effects on Cerebral Glucose Consumption and Blood Flow in Young Normals, Aged Normals, and Alzheimer's Disease Patients , 1997, NeuroImage.

[76]  S. Yamada,et al.  Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists. , 1997, Life sciences.

[77]  T. Thomas,et al.  beta-Amyloid induces cerebrovascular endothelial dysfunction in the rat brain. , 1997, Neurological research.

[78]  B. Pappas,et al.  Chronic ischemia: memory impairment and neural pathology in the rat. , 1997, Annals of the New York Academy of Sciences.

[79]  R. Kalaria.  Cerebrovascular Degeneration Is Related to Amyloid‐β Protein Deposition in Alzheimer's Disease a , 1997 .

[80]  G. Shah,et al.  GLUT-1 Expression in the Cerebra of Patients with Alzheimer’s Disease , 1997, Neurobiology of Aging.

[81]  E. Vaucher,et al.  Reduced cortical vasodilatory response to stimulation of the nucleus basalis of Meynert in the aged rat and evidence for a control of the cerebral circulation. , 1997, Annals of the New York Academy of Sciences.

[82]  H. Chui,et al.  Vascular Basement Membrane Pathology and Alzheimer's Disease , 1997, Annals of the New York Academy of Sciences.

[83]  R. Vos,et al.  Cerebrovascular Hypoperfusion: A Risk Factor for Alzheimer's Disease? , 1997, Annals of the New York Academy of Sciences.

[84]  P. Hof,et al.  Brain Microvascular Changes in Alzheimer's Disease and Other Dementias a , 1997, Annals of the New York Academy of Sciences.

[85]  P. Hutchins,et al.  Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. , 1997, Endocrinology.

[86]  D. D'urso,et al.  Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[87]  E. Hamel,et al.  Journal of Cerebral Blood Flow and Metabolism Astroglial and Vascular Interactions of Noradrenaline Terminals in the Rat Cerebral Cortex , 2022 .

[88]  M. Mullan,et al.  Superoxide free radical and intracellular calcium mediate Aβ 1–42 induced endothelial toxicity , 1997, Brain Research.

[89]  J. Rhodin,et al.  In vivo vascular damage, leukocyte activation and inflammatory response induced by beta-amyloid. , 1997, Journal of submicroscopic cytology and pathology.

[90]  G. Shah,et al.  Age-related changes in the blood-brain barrier , 1997, Experimental Gerontology.

[91]  H. Nishikawa,et al.  Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats , 1997, Neuroscience.

[92]  G. Bonvento,et al.  Autoradiographic Evidence for Flow-Metabolism Uncoupling During Stimulation of the Nucleus Basalis of Meynert in the Conscious Rat , 1997, Journal of Cerebral Blood Flow and Metabolism.

[93]  A. Hudetz,et al.  Blood Flow in the Cerebral Capillary Network: A Review Emphasizing Observations with Intravital Microscopy , 1997, Microcirculation.

[94]  E. Hamel,et al.  Cholinergic basal forebrain projections to nitric oxide synthase-containing neurons in the rat cerebral cortex , 1997, Neuroscience.

[95]  R. Roman,et al.  Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. , 1997, Journal of vascular research.

[96]  T Katsuta,et al.  Decreased local cerebral blood flow in young and aged spontaneously hypertensive rats. , 1997, Fukuoka igaku zasshi = Hukuoka acta medica.

[97]  M. Verbeek,et al.  Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β Protein , 1997 .

[98]  R. Sutherland,et al.  Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats , 1997, Neuroscience Letters.

[99]  A. Hofman,et al.  Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study , 1997, The Lancet.

[100]  I. Skoog.  The relationship between blood pressure and dementia: a review. , 1997, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[101]  M. Verbeek,et al.  Rapid degeneration of cultured human brain pericytes by amyloid beta protein. , 1997, Journal of neurochemistry.

[102]  R. Kalaria.  Cerebrovascular degeneration is related to amyloid-beta protein deposition in Alzheimer's disease. , 1997, Annals of the New York Academy of Sciences.

[103]  T. Abe.  [Calcium channels]. , 1997, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[104]  J. Borredon,et al.  Tacrine overcompensates for the decreased blood flow induced by basal forebrain lesion in the rat , 1996, Neuroreport.

[105]  J. Firth,et al.  Pressure-induced myogenic responses in human isolated cerebral resistance arteries. , 1996, Stroke.

[106]  G. Bonvento,et al.  SEROTONIN IN THE REGULATION OF BRAIN MICROCIRCULATION , 1996, Progress in Neurobiology.

[107]  M. Miyamoto,et al.  Effect of TAK-147, a novel AChE inhibitor, on cerebral energy metabolism , 1996, Neurobiology of Aging.

[108]  K. Hirschi,et al.  Pericytes in the microvasculature. , 1996, Cardiovascular research.

[109]  B. Zlokovic.  Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. , 1996, Life Science.

[110]  K. Opeskin.  Cerebral amyloid angiopathy. A review. , 1996, The American journal of forensic medicine and pathology.

[111]  H. Winn,et al.  Adenosine-induced release of nitric oxide from cortical astrocytes. , 1996, Neuroreport.

[112]  Lucien T. Thompson,et al.  Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus. , 1996, Life sciences.

[113]  M. Barcikowska,et al.  Evidence of blood‐brain barrier permeability/leakage for circulating human Alzheimer's β‐amyloid‐(1–42)‐peptide , 1996, Neuroreport.

[114]  P. Luiten,et al.  Ultrastructural localization of cholinergic muscarinic receptors in rat brain cortical capillaries , 1996, Brain Research.

[115]  D. Ingram,et al.  Laminins in the adult and aged brain , 1996, Molecular and chemical neuropathology.

[116]  B. Lernfelt,et al.  15-year longitudinal study of blood pressure and dementia , 1996, The Lancet.

[117]  B. Pappas,et al.  Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction , 1996, Brain Research.

[118]  P. Kailasnath,et al.  Computer modeling of cerebral blood flow following internal carotid artery occlusion. , 1996, Neurological research.

[119]  D. Premkumar,et al.  Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease. , 1996, Brain research. Molecular brain research.

[120]  R N Kalaria,et al.  Cerebral vessels in ageing and Alzheimer's disease. , 1996, Pharmacology & therapeutics.

[121]  F. Amenta,et al.  Age-related changes in brain microanatomy: Sensitivity to treatment with the dihydropyridine calcium channel blocker darodipine (PY 108-068) , 1995, Brain Research Bulletin.

[122]  R. Kalaria,et al.  Increased collagen content of cerebral microvessels in Alzheimer's disease , 1995, Brain Research.

[123]  Luz Claudio,et al.  Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients , 1995, Acta Neuropathologica.

[124]  E. Hamel,et al.  Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[125]  Shinn-ZongLin,et al.  Hemodilution Accelerates the Passage of Plasma (Not Red Cells) Through Cerebral Microvessels in Rats , 1995 .

[126]  Y. Chiang,et al.  Hemodilution accelerates the passage of plasma (not red cells) through cerebral microvessels in rats. , 1995, Stroke.

[127]  M. Moskowitz,et al.  Hypertension in mice lacking the gene for endothelial nitric oxide synthase , 1995, Nature.

[128]  E. Vaucher,et al.  Autoradiographic distribution of cerebral blood flow increases elicited by stimulation of the nucleus basalis magnocellularis in the unanesthetized rat , 1995, Brain Research.

[129]  G. Weinstein,et al.  Effects of Nimodipine and Verapamil on Cerebral Blood Flow and Cerebrovascular Reactivity in Conscious Rabbits , 1995, Annals of the New York Academy of Sciences.

[130]  S. Ibayashi,et al.  Cerebral Blood Flow and Metabolism in Hypertensive Patients with Cerebral Infarction , 1995, Angiology.

[131]  T. Lovick,et al.  Distribution of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent diaphorase staining in intraparenchymal blood vessels of the rat brain , 1995, Neuroscience Letters.

[132]  H. Hoshi,et al.  High-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[133]  W. Jagust,et al.  Reduced Temporal Lobe Glucose Metabolism in Aging , 1995, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[134]  M. Jüptner,et al.  Review: Does Measurement of Regional Cerebral Blood Flow Reflect Synaptic Activity?—Implications for PET and fMRI , 1995, NeuroImage.

[135]  S. Ibayashi,et al.  Cerebral blood flow and brain function in hypertension. , 1995, Hypertension research : official journal of the Japanese Society of Hypertension.

[136]  B. Siesjö,et al.  Glutamate, calcium, and free radicals as mediators of ischemic brain damage. , 1995, The Annals of thoracic surgery.

[137]  P. Hedera,et al.  Differential degeneration of the cerebral microvasculature in Alzheimer's disease. , 1995, Neuroreport.

[138]  F. Amenta,et al.  Effect of long term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats , 1995, Mechanisms of Ageing and Development.

[139]  H. Wiśniewski,et al.  In vitro production of β-amyloid in smooth muscle cells isolated from amyloid angiopathy-affected vessels , 1995, Neuroscience Letters.

[140]  R. M. Lee,et al.  Morphology of cerebral arteries. , 1995, Pharmacology & therapeutics.

[141]  J. Lincoln.  Innervation of cerebral arteries by nerves containing 5-hydroxytryptamine and noradrenaline. , 1995, Pharmacology & therapeutics.

[142]  F. Woimant,et al.  [Cerebral amyloid angiopathies]. , 1995, Annales de medecine interne.

[143]  J. B. Salom,et al.  Calcium channels in cerebral arteries. , 1995, Pharmacology & therapeutics.

[144]  N. Branston.  The physiology of the cerebrovascular parasympathetic innervation. , 1995, British journal of neurosurgery.

[145]  J. Traber,et al.  Calcium Antagonists in Aging Brain , 1994, Annals of the New York Academy of Sciences.

[146]  P. Luiten,et al.  Cerebrovascular, Neuronal, and Behavioral Effects of Long‐Term Ca2+ Channel Blockade in Aging Normotensive and Hypertensive Rat Strains , 1994, Annals of the New York Academy of Sciences.

[147]  E. Vaucher,et al.  Autoradiographic study of the cerebrovascular effects of stimulation of the substantia innominata: convenient stimulation paradigm. , 1994, Journal of the autonomic nervous system.

[148]  Hiroyuki Ohta,et al.  Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats , 1994, Brain Research.

[149]  W. Honer,et al.  Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease , 1994, Annals of neurology.

[150]  T. Kawanami,et al.  Electron microscopy of the blood‐brain barrier in disease , 1994, Microscopy research and technique.

[151]  N. Lassen,et al.  Heterogeneity of neocortical cerebral blood flow deficits in dementia of the Alzheimer type: a [99mTc]-d,l-HMPAO SPECT study. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[152]  Y Yonekura,et al.  Altered cerebral energy metabolism in Alzheimer's disease: a PET study. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[153]  P. Schubert,et al.  The use of ion-sensitive electrodes and fluorescence imaging in hippocampal slices for studying pathological changes of intracellular Ca2+ regulation. , 1994, Journal of neural transmission. Supplementum.

[154]  J. Muir,et al.  Excitotoxic lesions of basal forebrain cholinergic neurons: Effects on learning, memory and attention , 1993, Behavioural Brain Research.

[155]  M. Ito.  [Physiology of cerebral blood flow and metabolism]. , 1993, Nihon rinsho. Japanese journal of clinical medicine.

[156]  J. Berman,et al.  Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells , 1993, Brain Research.

[157]  S. Marenco,et al.  Regional Cerebral Blood Flow in Chronic Hypertension: A Correlative Study , 1993, Stroke.

[158]  N. Morel,et al.  Pericyte physiology , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[159]  J. Meyer,et al.  Leuko-araiosis and cerebral perfusion in normal aging. , 1993, Experimental aging research.

[160]  A. Scremin,et al.  Prolonged Effects of Cholinesterase Inhibition with Eptastigmine on the Cerebral Blood Flow-Metabolism Ratio of Normal Rats , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[161]  M. A. Bell,et al.  Microvascular Density of the Human Paraventricular Nucleus Decreases with Aging but Not Hypertension , 1993, Experimental Neurology.

[162]  D. Heistad,et al.  Effects of aging on cerebral vascular responses to serotonin in rats. , 1993, The American journal of physiology.

[163]  A. Strosberg,et al.  Nitric oxide and endothelin secretion by brain microvessel endothelial cells: Regulation by cyclic nucleotides , 1993, Journal of cellular physiology.

[164]  M. Wahl,et al.  Regulation of cerebral blood flow--a brief review. , 1993, Acta neurochirurgica. Supplementum.

[165]  J. C. de la Torre,et al.  Can disturbed brain microcirculation cause Alzheimer's disease? , 1993, Neurological research.

[166]  J. Hardebo,et al.  The cerebrovascular parasympathetic innervation. , 1993, Cerebrovascular and brain metabolism reviews.

[167]  R. Janzer,et al.  Astrocytes secrete a factor inducing the expression of HT7-protein and neurothelin in endothelial cells of chorioallantoic vessels. , 1993, Advances in experimental medicine and biology.

[168]  A. Mayevsky,et al.  Brain vasculature and mitochondrial responses to ischemia in gerbils. I. Basic anatomical patterns and biochemical correlates , 1992, Brain Research.

[169]  H. Vinters,et al.  A morphometric study of the blood-brain barrier in Alzheimer's disease. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[170]  P. Luiten,et al.  Changes in PKC gamma immunoreactivity in mouse hippocampus induced by spatial discrimination learning , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[171]  B. Sahakian,et al.  A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[172]  A. Trzebski,et al.  Local cerebral blood flow responses in rats to hypercapnia and hypoxia in the rostral ventrolateral medulla and in the cortex. , 1992, Journal of the autonomic nervous system.

[173]  Macrae I Mhairi.  New models of focal cerebral ischaemia. , 1992 .

[174]  G Marchal,et al.  Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. , 1992, Archives of neurology.

[175]  I. Romero,et al.  Astrocyte‐endothelial interaction: physiology and pathology , 1992, Neuropathology and applied neurobiology.

[176]  S. Sobin,et al.  Age related alterations in the response of the pial arterioles to adenosine in the rat , 1992, Mechanisms of Ageing and Development.

[177]  P. Luiten,et al.  Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application , 1992, Mechanisms of Ageing and Development.

[178]  William J. Jagust,et al.  Reduced temporal lobe blood flow in alzheimer's disease , 1992, Neurobiology of Aging.

[179]  M. Brodie,et al.  Dihydropyridine Calcium Antagonists in Mice: Blood and Brain Pharmacokinetics and Efficacy Against Pentylenetetrazol Seizures , 1992, Epilepsia.

[180]  B. Pappas,et al.  Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats , 1992, Brain Research.

[181]  L. Hersh,et al.  Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease , 1992, Neurobiology of Aging.

[182]  W. Gispen,et al.  Nimodipine effects on cerebral microvessels and sciatic nerve in aging rats , 1992, Neurobiology of Aging.

[183]  Jörg Meyer,et al.  Chapter 18: Development of an in vitro cell culture system to mimic the blood-brain barrier , 1992 .

[184]  F Shishido,et al.  Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography. , 1992, Neurological research.

[185]  D. Selkoe,et al.  Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. , 1992, The American journal of pathology.

[186]  H. Galla,et al.  Development of an in vitro cell culture system to mimic the blood-brain barrier. , 1992, Progress in brain research.

[187]  I Mhairi Macrae,et al.  New models of focal cerebral ischaemia. , 1992, British journal of clinical pharmacology.

[188]  H. Chui,et al.  Association between vascular basement membrane components and the lesions of Alzheimer's disease , 1991, Journal of neuroscience research.

[189]  T. Miyakawa,et al.  Observations of Microvessels in the Brain with Alzheimer's Disease by the Scanning Electron Microscopy , 1991, The Japanese journal of psychiatry and neurology.

[190]  S. Arneric,et al.  Cortical cerebral blood flow governed by the basal forebrain: Age-related Impairments , 1991, Neurobiology of Aging.

[191]  J. Berliner,et al.  In vitro interaction of astrocytes and pericytes with capillary-like structures of brain microvessel endothelium. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[192]  A. Mooradian,et al.  Glucose transport is reduced in the blood-brain barrier of aged rats , 1991, Brain Research.

[193]  T. Miyakawa,et al.  Vascular Changes in the Brains with Alzheimer's Disease , 1991, The Japanese journal of psychiatry and neurology.

[194]  S. Murota,et al.  Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells. , 1991, Stroke.

[195]  Kortaro Tanaka,et al.  Effects of Lesioning of the Substantia Innominata on Autoregulation of Local Cerebral Blood Flow in Rats , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[196]  橋村 哲男.  Morphological changes of blood vessels in the brain with Alzheimer's disease , 1991 .

[197]  D. Heistad,et al.  Development of collaterals in the cerebral circulation. , 1991, Blood vessels.

[198]  M Ursino,et al.  Mechanisms of cerebral blood flow regulation. , 1991, Critical reviews in biomedical engineering.

[199]  J. Beckman.  The double-edged role of nitric oxide in brain function and superoxide-mediated injury. , 1991, Journal of developmental physiology.

[200]  R. Nitsch,et al.  Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases , 1991, Journal of neural transmission. Parkinson's disease and dementia section.

[201]  S. Hirai,et al.  The amyloid β-protein precursor is localized in smooth muscle cells of leptomeningeal vessels , 1990, Brain Research.

[202]  T. Stijnen,et al.  Influence of biological factors on changes in mean cerebral blood flow velocity in normal ageing: a transcranial Doppler study. , 1990, Neurological research.

[203]  P. Luiten,et al.  Microvascular changes in aged rat forebrain. Effects of chronic nimodipine treatment , 1990, Neurobiology of Aging.

[204]  Y. Yamori,et al.  Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats. , 1990, Stroke.

[205]  H. Chui,et al.  Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review , 1990, Brain Research Bulletin.

[206]  S. Ibayashi,et al.  Acute effects of antihypertensive agents on cerebral blood flow in hypertensive rats. , 1990, European journal of pharmacology.

[207]  Richard S. J. Frackowiak,et al.  Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. , 1990, Brain : a journal of neurology.

[208]  E. Mackenzie,et al.  Models of hypoxia and cerebral ischemia. , 1990, Pharmacopsychiatry.

[209]  H. Chui,et al.  Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease , 1990, Brain Research.

[210]  D Wyper,et al.  Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[211]  J. Skarphedinsson,et al.  Effect of the calcium antagonists felodipine and nimodipine on cortical blood flow in the spontaneously hypertensive rat. , 1989, Journal of Cardiovascular Pharmacology.

[212]  F. Schmitt,et al.  Assessing Utility of Single Photon Emission Computed Tomography (SPECT) Scan in Alzheimer Disease: Correlation with Cognitive Severity , 1990, Alzheimer disease and associated disorders.

[213]  D. Harder,et al.  Mechanoreception by the endothelium: mediators and mechanisms of pressure- and flow-induced vascular responses. , 1990, Blood vessels.

[214]  D. Thomas,et al.  The influence of haematocrit on the cerebral circulation , 1989, Acta neurologica Scandinavica. Supplementum.

[215]  W. Jagust,et al.  Regional cerebral glucose transport and utilization in Alzheimer's disease , 1989, Neurology.

[216]  R. Koehler,et al.  Chemodenervation does not alter cerebrovascular response to hypoxic hypoxia. , 1989, The American journal of physiology.

[217]  H. W. Harris,et al.  Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[218]  R N Kalaria,et al.  Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease , 1989, Journal of neurochemistry.

[219]  J. Traber,et al.  Pharmacological basis for the use of nimodipine in central nervous system disorders , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[220]  H. Rusinek,et al.  Cerebral cortical and white matter reactivity to carbon dioxide. , 1989, Stroke.

[221]  O. Inanami,et al.  Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats , 1989, Neuroscience Letters.

[222]  L. Edvinsson,et al.  Neuropeptides in the cerebral circulation. , 1989, Cerebrovascular and brain metabolism reviews.

[223]  G. Wieneke,et al.  Transcranial pulsed Doppler measurements of blood velocity in the middle cerebral artery: reference values at rest and during hyperventilation in healthy volunteers in relation to age and sex. , 1989, Ultrasound in medicine & biology.

[224]  A. Scheibel,et al.  Alzheimer's disease as a capillary dementia. , 1989, Annals of medicine.

[225]  M. Harrison.  Influence of haematocrit in the cerebral circulation. , 1989, Cerebrovascular and brain metabolism reviews.

[226]  A. Mooradian.  Effect of aging on the blood-brain barrier , 1988, Neurobiology of Aging.

[227]  W. Pardridge.  Does the brain's gatekeeper falter in aging? , 1988, Neurobiology of Aging.

[228]  R. Levy,et al.  CBF Tomograms with [99mTc-HM-PAO in Patients with Dementia (Alzheimer Type and HIV) and Parkinson's Disease—Initial Results , 1988, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[229]  D. Nochlin,et al.  The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. , 1988, The American journal of pathology.

[230]  A. Komatani,et al.  Assessment of demented patients by dynamic SPECT of inhaled xenon-133. , 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[231]  Gwenn S. Smith,et al.  Scopolamine Reduces Frontal Cortex Perfusion , 1988, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[232]  G. Fleckenstein-Grün,et al.  Mechanism of action of calcium antagonists in heart and vascular smooth muscle. , 1988, European heart journal.

[233]  Y. Uehara,et al.  Morphological changes of microvessels in the brain with Alzheimer's disease. , 1988, The Japanese journal of psychiatry and neurology.

[234]  P. Janicki,et al.  Single-dose kinetics of nifedipine in rat plasma and brain. , 1988, Pharmacology.

[235]  R. Shivers,et al.  Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. , 1987, Brain research.

[236]  T. Miyakawa,et al.  Ultrastructural Changes of Blood Vessels in the Cerebral Cortex in Alzheimer's Disease , 1987, The Japanese journal of psychiatry and neurology.

[237]  H. Vinters,et al.  A quantitative analysis of blood-brain barrier ultrastructure in the aging human. , 1987, Microvascular research.

[238]  H. Vinters.  Cerebral amyloid angiopathy. A critical review. , 1987, Stroke.

[239]  H. Hechtman,et al.  Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wall , 1987, The Journal of cell biology.

[240]  B. Reisberg,et al.  Senile Dementia: Outlook for the Future , 1987 .

[241]  W. Kuschinsky,et al.  Interdependency of local capillary density, blood flow, and metabolism in rat brains. , 1986, The American journal of physiology.

[242]  F Shishido,et al.  Reduction in regional cerebral metabolic rate of oxygen during human aging. , 1986, Stroke.

[243]  J. Povlishock,et al.  O2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins. , 1986, The American journal of physiology.

[244]  M. Tommasi,et al.  Substance P-immunoreactive astrocytes related to deep white matter and striatal blood vessels in human brain , 1986, Brain Research.

[245]  覚久 田中,et al.  抗高血圧薬，Budralazine の脳循環に及ぼす影響 , 1986 .

[246]  K. Iwata,et al.  Regional cerebral blood flow changes in aging. , 1986, Acta radiologica. Supplementum.

[247]  H. Wiśniewski,et al.  Alzheimer's disease and related disorders. , 1986, British medical bulletin.

[248]  S. Tanaka,et al.  [Effect of an antihypertensive drug, budralazine, on the cerebral circulation in spontaneously hypertensive rats]. , 1986, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[249]  A. Katz,et al.  Cellular actions and pharmacology of calcium-channel blockers. , 1985, The American journal of emergency medicine.

[250]  S. Hoyer.  The effect of age on glucose and energy metabolism in brain cortex of rats. , 1985, Archives of gerontology and geriatrics.

[251]  A. Gjedde,et al.  Double-Tracer Study of the Fine Regional Blood—Brain Glucose Transfer in the Rat by Computer-Assisted Autoradiography , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[252]  M. Ball.  Senile Dementia: Outlook for the Future , 1985 .

[253]  Robert P. Friedland,et al.  Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization , 1985, Neuroscience Letters.

[254]  M. Wahl.  Local Chemical, Neural, and Humoral Regulation of Cerebrovascular Resistance Vessels , 1985, Journal of cardiovascular pharmacology.

[255]  M. Tabaton,et al.  Endothelial mitochondrial content of cerebral cortical capillaries in Alzheimer's disease. An ultrastructural quantitative study. , 1985, European neurology.

[256]  J. Wood,et al.  Rheology of the Cerebral Circulation , 1984, Neurosurgery.

[257]  H. Tachibana,et al.  Changing topographic patterns of human cerebral blood flow with age measured by xenon CT. , 1984, AJR. American journal of roentgenology.

[258]  J. Slakter,et al.  An experimental model of carotid artery occlusive disease. , 1984, American journal of ophthalmology.

[259]  O B Paulson,et al.  Cerebral autoregulation. , 1984, Stroke.

[260]  D E Kuhl,et al.  The effect of normal aging on patterns of local cerebral glucose utilization , 1984, Annals of neurology.

[261]  S. Ibayashi,et al.  Disruption of blood‐brain barrier following bilateral carotid artery occlusion in spontaneously hypertensive rats. A quantitative study. , 1983, Stroke.

[262]  B. Marks,et al.  Identification of Muscarinic Receptors in Rat Cerebral Cortical Microvessels , 1983, Journal of neurochemistry.

[263]  T. Samorajski,et al.  Age-related changes in rat brain capillaries , 1983, Neurobiology of Aging.

[264]  H. Schmid-schönbein.  Macrorheology and microrheology of blood in cerebrovascular insufficiency. , 1983, European neurology.

[265]  R. Poster.  Pharmacology, 3rd edn: by R. G. Penn, Ballière Tindall, London, 1980. £4.75 (x + 320 pages) ISBN 0 7020 0822 2 , 1982 .

[266]  J. Marshall,et al.  EFFECT OF HAEMATOCRIT ON CAROTID STENOSIS AND CEREBRAL INFARCTION , 1981, The Lancet.

[267]  R. Traystman,et al.  Effects of changes in arterial O2 content on cerebral blood flow in the lamb. , 1981, The American journal of physiology.

[268]  T. Pearson,et al.  EFFECT OF HÆMATOCRIT ON CEREBRAL BLOOD-FLOW IN MAN , 1977, The Lancet.

[269]  R. Russell,et al.  Effect of haematocrit on cerebral blood-flow in man. , 1977, Lancet.

[270]  N. Lassen,et al.  Physiology of cerebral blood flow. , 1976, British journal of anaesthesia.

[271]  D. A. Mcdonald,et al.  The distribution of blood to the brain , 1951, The Journal of physiology.