Sonic hedgehog: a common signal for ventral patterning along the rostrocaudal axis of the neural tube.

The vertebrate hedgehog-related gene, sonic hedgehog, is expressed in ventral domains along the entire rostrocaudal length of the neural tube, including the forebrain. Shh induces the differentiation of ventral neuronal cell types in explants derived from prospective forebrain regions of the neural plate. Neurons induced in explants derived from diencephalic and telencephalic levels of the neural plate express the LIM homeodomain protein Islet-1, but these neurons possess distinct identities that match those of the ventral neurons normally generated in these two subdivisions of the forebrain. These results, together with other studies of neuronal differentiation at caudal levels of the neural tube, suggest that a single inducing molecule, Shh, mediates the induction of distinct ventral neuronal cell types along the entire rostrocaudal extent of the embryonic central nervous system.

[1]  T. Lints,et al.  Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube , 1995, Cell.

[2]  S. Wilson,et al.  Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. , 1995, Development.

[3]  A. Lumsden,et al.  Independent assignment of antero-posterior and dorso-ventral positional values in the developing chick hindbrain , 1995, Current Biology.

[4]  M. Tessier-Lavigne,et al.  Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons , 1995, Cell.

[5]  T. Jessell,et al.  Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes , 1994, Cell.

[6]  M. Seldin,et al.  Products, genetic linkage and limb patterning activity of a murine hedgehog gene. , 1994, Development.

[7]  J. Rubenstein,et al.  The embryonic vertebrate forebrain: the prosomeric model. , 1994, Science.

[8]  T. Jessell,et al.  Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord , 1994, Cell.

[9]  H. Okamoto,et al.  Developmental regulation of Islet‐1 mRNA expression during neuronal differentiation in embryonic zebrafish , 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

[10]  R. Toyama,et al.  Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system , 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

[11]  P. Ingham,et al.  A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos , 1993, Cell.

[12]  C. Tabin,et al.  Sonic hedgehog mediates the polarizing activity of the ZPA , 1993, Cell.

[13]  Andrew P. McMahon,et al.  Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity , 1993, Cell.

[14]  Luis Puelles,et al.  Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization , 1993, Trends in Neurosciences.

[15]  J. Smith.  Dorso-ventral patterning in the neural tube , 1993, Current Biology.

[16]  M. Goulding,et al.  Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. , 1993, Development.

[17]  C. Stern,et al.  Segmental organization of embryonic diencephalon , 1993, Nature.

[18]  V. Korzh,et al.  Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation. , 1993, Development.

[19]  T. Jessell,et al.  Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate , 1993, Cell.

[20]  T. Jessell,et al.  Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member , 1993, Cell.

[21]  P. Beachy,et al.  Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog , 1992, Cell.

[22]  A. R. I. Altaba.  Planar and vertical signals in the induction and patterning of the Xenopus nervous system , 1992 .

[23]  J. Gerhart,et al.  Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis. , 1992, Science.

[24]  T. Jessell,et al.  Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. , 1992, Science.

[25]  S. Weiss,et al.  Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. , 1992, Science.

[26]  D. Duboule,et al.  Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain , 1992, Neuron.

[27]  R. Lauro,et al.  The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. , 1991, Development.

[28]  S. Thor,et al.  The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat , 1991, Neuron.

[29]  T. Jessell,et al.  Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord , 1991, Cell.

[30]  T. Jessell,et al.  Mesodermal control of neural cell identity: floor plate induction by the notochord. , 1990, Science.

[31]  Stefan Thor,et al.  Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain , 1990, Nature.

[32]  R. Keynes,et al.  Segmental patterns of neuronal development in the chick hindbrain , 1989, Nature.

[33]  L. Puelles,et al.  Segment‐related, mosaic neurogenetic pattern in the forebrain and mesencephalon of early chick embryos: I. Topography of ache‐positive neuroblasts up to stage HH18 , 1987, The Journal of comparative neurology.

[34]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[35]  V. Hamburger,et al.  A series of normal stages in the development of the chick embryo , 1951, Journal of morphology.

[36]  Frances Cummings Roach.  Differentiation of the central nervous system after axial reversals of the medullary plate of Amblystoma , 1945 .

[37]  B. Kingsbury.  The developmental significance of the floor‐plate of the brain and spinal cord , 1930 .

[38]  B. Hogan,et al.  Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. , 1994, Developmental biology.

[39]  T. Jessell,et al.  Induction of floor plate differentiation by contact-dependent, homeogenetic signals. , 1993, Development.

[40]  T. Jessell,et al.  Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate. , 1991, Development (Cambridge, England). Supplement.

[41]  T. Jessell,et al.  Floor plate-derived signals and the control of neural cell pattern in vertebrates. , 1990, Harvey lectures.

[42]  S. Vaage.  The segmentation of the primitive neural tube in chick embryos (Gallus domesticus). A morphological, histochemical and autoradiographical investigation. , 1969, Ergebnisse der Anatomie und Entwicklungsgeschichte.