Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.
暂无分享,去创建一个
[1] D. Katz,et al. Neuroepigenetic mechanisms in disease , 2017, Epigenetics & Chromatin.
[2] Nick C Fox,et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease , 2017, Nature Genetics.
[3] Zeran Li,et al. CELL-TYPE PROFILING TO IDENTIFY THE TRANSCRIPTOMIC DOWNSTREAM EVENTS TRIGGERED BY EARLY-ONSET AUTOSOMAL DOMINANT AD MUTATIONS , 2017, Alzheimer's & Dementia.
[4] K. Hao,et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease , 2017, Nature Neuroscience.
[5] M. Tsolaki,et al. Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer’s disease , 2017, Acta Neuropathologica.
[6] Ronald C. Petersen,et al. TYROBP genetic variants in early-onset Alzheimer's disease , 2016, Neurobiology of Aging.
[7] David Haussler,et al. The UCSC Genome Browser database: 2017 update , 2016, Nucleic Acids Res..
[8] J. Buxbaum,et al. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease , 2016, Genome Medicine.
[9] K. Rawlik,et al. Imputation of DNA Methylation Levels in the Brain Implicates a Risk Factor for Parkinson’s Disease , 2016, Genetics.
[10] Sarah A. Gagliano,et al. Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases , 2016, bioRxiv.
[11] Kristel Sleegers,et al. Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond , 2016, The Lancet Neurology.
[12] M. Ronaghi,et al. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain , 2016, Science.
[13] O. Andreassen,et al. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. , 2016, JAMA neurology.
[14] C. Broeckhoven,et al. Molecular genetics of early-onset Alzheimer's disease revisited , 2016, Alzheimer's & Dementia.
[15] J. Lambert,et al. miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease , 2016, Alzheimer's Research & Therapy.
[16] Ben A. Barres,et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models , 2016, Science.
[17] Michele Vendruscolo,et al. A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation , 2016, Proceedings of the National Academy of Sciences.
[18] Giuliano Binetti,et al. A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer’s disease , 2016, Acta Neuropathologica.
[19] Juan González-Vallinas,et al. A new view of transcriptome complexity and regulation through the lens of local splicing variations , 2016, eLife.
[20] C. Broeckhoven,et al. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study , 2015, The Lancet Neurology.
[21] D. Serie,et al. Late-onset Alzheimer disease risk variants mark brain regulatory loci , 2015, Neurology: Genetics.
[22] Taigang He,et al. Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease , 2015, Scientific Reports.
[23] J. Gilbert,et al. Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci , 2015, Molecular and Cellular Neuroscience.
[24] S. Quake,et al. A survey of human brain transcriptome diversity at the single cell level , 2015, Proceedings of the National Academy of Sciences.
[25] J. Schneider,et al. Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance , 2015, Nature Neuroscience.
[26] Manolis Kellis,et al. Alzheimer’s loci: epigenetic associations and interaction with genetic factors , 2015, Annals of clinical and translational neurology.
[27] L. Tan,et al. TYROBP in Alzheimer’s Disease , 2015, Molecular Neurobiology.
[28] H. Stefánsson,et al. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease , 2015, Nature Genetics.
[29] Manolis Kellis,et al. Large-scale epigenome imputation improves data quality and disease variant enrichment , 2015, Nature biotechnology.
[30] F. Edwards,et al. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. , 2015, Cell reports.
[31] Juha E. Jääskeläinen,et al. Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models , 2015, Neurobiology of Aging.
[32] Manolis Kellis,et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease , 2015, Nature.
[33] J. Gallacher,et al. Convergent genetic and expression data implicate immunity in Alzheimer's disease , 2014, Alzheimer's & Dementia.
[34] J. Satoh,et al. A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia , 2014, Gene regulation and systems biology.
[35] L. Lue,et al. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices , 2014, Brain pathology.
[36] Zugen Chen,et al. Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer’s Disease , 2014, Molecular Neurobiology.
[37] M. Esiri,et al. Genome-wide profiling of alternative splicing in Alzheimer's disease , 2014, Genomics Data.
[38] K. Lunetta,et al. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation , 2014, Annals of neurology.
[39] Carlos Cruchaga,et al. The epigenetic landscape of Alzheimer's disease , 2014, Nature Neuroscience.
[40] D. Bennett,et al. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease , 2014, Nature Neuroscience.
[41] Manolis Kellis,et al. Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci , 2014, Nature Neuroscience.
[42] J. Renger,et al. Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease , 2014, PloS one.
[43] Nick C Fox,et al. Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease , 2014, PLoS ONE.
[44] M. A. Alarcón,et al. Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies , 2014, PloS one.
[45] D. Borchelt,et al. Genetics of PICALM Expression and Alzheimer's Disease , 2014, PloS one.
[46] Nick C Fox,et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.
[47] L. Tan,et al. Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease. , 2013, Trends in molecular medicine.
[48] Chadwick M. Hales,et al. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease , 2013, Proceedings of the National Academy of Sciences.
[49] Manasi Malik,et al. CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing , 2013, The Journal of Neuroscience.
[50] J. Haines,et al. Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians , 2013, PLoS ONE.
[51] L. Tran,et al. Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.
[52] J. D. Mills,et al. RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism , 2013, Neuroscience Letters.
[53] M. Owen,et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology , 2013, Molecular Psychiatry.
[54] A. Singleton,et al. TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.
[55] A. Hofman,et al. Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.
[56] A. Goate,et al. Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains , 2012, PloS one.
[57] G. Breen,et al. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway , 2012, Molecular Psychiatry.
[58] J. Haines,et al. Identification and Confirmation of an Exonic Splicing Enhancer Variation in Exon 5 of the Alzheimer Disease Associated PICALM Gene , 2012, Annals of human genetics.
[59] R. Cancedda,et al. An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples , 2012, Disease Models & Mechanisms.
[60] Margaret A. Pericak-Vance,et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression , 2012, Neurology.
[61] J. D. Mills,et al. Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases , 2012, Neurobiology of Aging.
[62] Michael W. Weiner,et al. Genome-wide pathway analysis of memory impairment in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks , 2012, Brain Imaging and Behavior.
[63] B Croisile,et al. High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease , 2012, Molecular Psychiatry.
[64] M Mancuso,et al. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease , 2012, Molecular Psychiatry.
[65] N. Hübner,et al. Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain. , 2012, Archives of Neurology.
[66] Zugen Chen,et al. Cell adhesion molecules contribute to Alzheimer’s disease: multiple pathway analyses of two genome‐wide association studies , 2012, Journal of neurochemistry.
[67] J. Morris,et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[68] M. Albert,et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[69] Nick C Fox,et al. Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease , 2011, Nature Genetics.
[70] D. G. Clark,et al. Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease , 2011, Nature Genetics.
[71] J. Kril,et al. Understanding the pathogenesis of Alzheimer’s disease: will RNA‐Seq realize the promise of transcriptomics? , 2011, Journal of neurochemistry.
[72] E. Wijsman,et al. Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE , 2011, PLoS genetics.
[73] Weixiong Zhang,et al. Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks , 2010, BMC Systems Biology.
[74] Andrey Alexeyenko,et al. Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease , 2010, Journal of Human Genetics.
[75] Seth Love,et al. Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease , 2010, PloS one.
[76] Simon Heath,et al. Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis. , 2010, Journal of Alzheimer's disease : JAD.
[77] Sudha Seshadri,et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. , 2010, JAMA.
[78] P. Bosco,et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease , 2009, Nature Genetics.
[79] Christoph Lange,et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. , 2008, American journal of human genetics.
[80] J. Shendure. The beginning of the end for microarrays? , 2008, Nature Methods.
[81] B. Blencowe. Alternative Splicing: New Insights from Global Analyses , 2006, Cell.
[82] A. Levey,et al. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. , 2004, Archives of neurology.
[83] Christopher J. Lee,et al. Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. , 2002, Nucleic acids research.
[84] Alexander Meissner,et al. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. , 2015, JAMA neurology.
[85] L. Tan,et al. ABCA7 in Alzheimer’s Disease , 2014, Molecular Neurobiology.
[86] P. S. St George-Hyslop,et al. This month in archives of neurology. , 2012, Archives of neurology.
[87] Nick C Fox,et al. Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease , 2009 .
[88] H. Braak,et al. Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.