CRITICAL IN VITRO FACTORS IN EVALUATION OF GASTRIC ANTACIDS. I. POLYPEPTIDE INHIBITION.

In vitro investigation of a wide range of antacid materials contained in various commercially available dosage forms has indicated demonstrable differences in both the degree and rate of neutralization and in buffering capacities. Results obtained by using pH-titration curves reveal that the type of dosage form exerts an influence on the antacid properties of the same chemical compound. Inhibition of antacid activity of some compounds was observed when polypeptides were added to the artificial gastric fluid. It is thus conceivable that antacid activity could be completely curtailed if similar conditions are encountered in the human system.