IL-17A-producing Sinonasal MAIT Cells in Patients with Chronic Rhinosinusitis with Nasal Polyps.

[1]  B. Lambrecht,et al.  Adult chronic rhinosinusitis , 2020, Nature Reviews Disease Primers.

[2]  H. Ljunggren,et al.  MAIT cell activation and dynamics associated with COVID-19 disease severity , 2020, Science Immunology.

[3]  Morten Nielsen,et al.  Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 , 2020, Cell.

[4]  C. Bachert,et al.  Type 2 Inflammation in Chronic Rhinosinusitis without Nasal Polyps: Another Relevant Endotype. , 2020, The Journal of allergy and clinical immunology.

[5]  Jae Geun Lee,et al.  Human liver CD8+ MAIT cells exert TCR/MR1-independent innate-like cytotoxicity in response to IL-15. , 2020, Journal of hepatology.

[6]  Matthew R. Dillon,et al.  The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology , 2020, Allergy.

[7]  J. Kim,et al.  Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp , 2020, Allergy, asthma & immunology research.

[8]  W. Fokkens.  EPOS2020: a major step forward. , 2020, Rhinology.

[9]  P. Klenerman,et al.  MAIT Cells in Health and Disease. , 2020, Annual review of immunology.

[10]  C. Bachert,et al.  Endotypes of chronic rhinosinusitis: impact on management. , 2020, The Journal of allergy and clinical immunology.

[11]  E. Shin,et al.  Superantigen-related Th2 CD4+ T Cells in Non-asthmatic Chronic Rhinosinusitis with Nasal Polyps. , 2020, The Journal of allergy and clinical immunology.

[12]  D. Fairlie,et al.  Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli , 2020, bioRxiv.

[13]  D. Tang,et al.  Mucosal associated invariant T cells restrict allergic airway inflammation. , 2019, The Journal of allergy and clinical immunology.

[14]  P. Dearden,et al.  TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses. , 2019, Cell reports.

[15]  P. Klenerman,et al.  Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality , 2019, Cell reports.

[16]  C. Delacourt,et al.  Evidence for a Mait-17-High Phenotype In Children with Severe Asthma. , 2019, The Journal of allergy and clinical immunology.

[17]  J. McCluskey,et al.  The biology and functional importance of MAIT cells , 2019, Nature Immunology.

[18]  C. Bachert,et al.  Staphylococcus aureus Orchestrates Type 2 Airway Diseases. , 2019, Trends in molecular medicine.

[19]  C. Bachert,et al.  Cross-talk between Th2 and Th17 pathways in chronic rhinosinusitis with nasal polyps. , 2019, The Journal of allergy and clinical immunology.

[20]  D. Farber,et al.  Location, location, location: Tissue resident memory T cells in mice and humans , 2019, Science Immunology.

[21]  P. Klenerman,et al.  TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions , 2018, bioRxiv.

[22]  M. Moll,et al.  Tissue‐resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL‐17 , 2018, European journal of immunology.

[23]  C. Bachert,et al.  Innate lymphoid cells in the upper airways: importance of CD117 and IL-1RI expression , 2018, European Respiratory Journal.

[24]  D. Thorburn,et al.  MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation , 2018, Hepatology.

[25]  C. Bachert,et al.  Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota , 2018, Scientific Reports.

[26]  L. Chatenoud,et al.  Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma. , 2017, Clinical immunology.

[27]  A. McKenzie,et al.  TH2 cell development and function , 2017, Nature Reviews Immunology.

[28]  T. Wilkinson,et al.  IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection , 2017, The Journal of allergy and clinical immunology.

[29]  J. McCluskey,et al.  MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression , 2017, PLoS biology.

[30]  Wouter A. A. de Steenhuijsen Piters,et al.  The microbiota of the respiratory tract: gatekeeper to respiratory health , 2017, Nature Reviews Microbiology.

[31]  R. Djukanović,et al.  Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection. , 2016, American journal of respiratory and critical care medicine.

[32]  C. Bachert,et al.  Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania. , 2016, The Journal of allergy and clinical immunology.

[33]  J. Ma,et al.  CD8+ T cells with distinct cytokine‐producing features and low cytotoxic activity in eosinophilic and non‐eosinophilic chronic rhinosinusitis with nasal polyps , 2016, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[34]  P. Gevaert,et al.  Chronic Rhinosinusitis without Nasal Polyps. , 2016, The journal of allergy and clinical immunology. In practice.

[35]  A. Peters,et al.  Infectious Chronic Rhinosinusitis , 2016, The Journal of Allergy and Clinical Immunology: In Practice.

[36]  Edward C Hutchinson,et al.  MAIT cells are activated during human viral infections , 2016, Nature Communications.

[37]  C. Bachert,et al.  Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. , 2016, The Journal of allergy and clinical immunology.

[38]  S. Durham,et al.  IL-25/IL-33–responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa , 2016, The Journal of allergy and clinical immunology.

[39]  E. Andersson,et al.  MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation , 2016, Mucosal Immunology.

[40]  C. Bachert,et al.  Barrier function of the nasal mucosa in health and type‐2 biased airway diseases , 2016, Allergy.

[41]  Scott N. Mueller,et al.  Tissue-resident memory T cells: local specialists in immune defence , 2015, Nature Reviews Immunology.

[42]  R. Lee,et al.  Chronic rhinosinusitis pathogenesis. , 2015, The Journal of allergy and clinical immunology.

[43]  D. Hamilos.  Drivers of chronic rhinosinusitis: Inflammation versus infection. , 2015, The Journal of allergy and clinical immunology.

[44]  Borislav D. Dimitrov,et al.  Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms , 2015, The Journal of allergy and clinical immunology.

[45]  T. Morikawa,et al.  Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study , 2015, Allergy.

[46]  P. Klenerman,et al.  Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver , 2014, PLoS pathogens.

[47]  D. Sinderen,et al.  T-cell activation by transitory neo-antigens derived from distinct microbial pathways , 2014, Nature.

[48]  Y. Gho,et al.  Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis , 2014, Allergy.

[49]  P. Klenerman,et al.  CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner , 2013, European journal of immunology.

[50]  C. Bachert,et al.  Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. , 2013, The Journal of allergy and clinical immunology.

[51]  A. Kato,et al.  B-lymphocyte lineage cells and the respiratory system. , 2013, The Journal of allergy and clinical immunology.

[52]  Kwang-Chul Ahn,et al.  Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways. , 2013, The Journal of allergy and clinical immunology.

[53]  C. Akdis,et al.  Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4. , 2012, The Journal of allergy and clinical immunology.

[54]  Malcolm J. McConville,et al.  MR1 presents microbial vitamin B metabolites to MAIT cells , 2012, Nature.

[55]  S. Lynch,et al.  Sinus Microbiome Diversity Depletion and Corynebacterium tuberculostearicum Enrichment Mediates Rhinosinusitis , 2012, Science Translational Medicine.

[56]  K. Ikeda,et al.  Relationships between IL-17A and macrophages or MUC5AC in eosinophilic chronic rhinosinusitis and proposed pathological significance , 2012, Allergy & rhinology.

[57]  C. Bachert,et al.  IL-17A as a regulator of neutrophil survival in nasal polyp disease of patients with and without cystic fibrosis. , 2012, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

[58]  Hergen Spits,et al.  Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 , 2011, Nature Immunology.

[59]  J Bousquet,et al.  Chronic rhinosinusitis in Europe – an underestimated disease. A GA2LEN study , 2011, Allergy.

[60]  Guang-Yu Li,et al.  The Characterization of IL-17A Expression in Patients with Chronic Rhinosinusitis with Nasal Polyps , 2011, American journal of rhinology & allergy.

[61]  O. Lantz,et al.  Antimicrobial activity of mucosal-associated invariant T cells , 2010, Nature Immunology.

[62]  M. Okano,et al.  Regulation and characterization of IL-17A expression in patients with chronic rhinosinusitis and its relationship with eosinophilic inflammation. , 2010, The Journal of allergy and clinical immunology.

[63]  Matthew S. Cook,et al.  Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells , 2010, PLoS biology.

[64]  D. Wang,et al.  Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. , 2009, The Journal of allergy and clinical immunology.

[65]  K. Miyahara,et al.  Role of Interleukin-17A in the Eosinophil Accumulation and Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps Associated with Asthma , 2009, International Archives of Allergy and Immunology.

[66]  M. Hatano,et al.  IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. , 2008, American journal of respiratory and critical care medicine.

[67]  C. Bachert,et al.  Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. , 2008, The Journal of allergy and clinical immunology.

[68]  P. Lipsky,et al.  Generation and Regulation of Human Th1-Biased Immune Responses In Vivo: A Critical Role for IL-4 and IL-10 1 , 2004, The Journal of Immunology.

[69]  Olivier Lantz,et al.  Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1 , 2003, Nature.

[70]  Philip Smith,et al.  IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. , 2002, Immunity.

[71]  P. Foster,et al.  IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. , 2001, The Journal of allergy and clinical immunology.

[72]  M. Bonneville,et al.  An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals , 1999, The Journal of experimental medicine.

[73]  V. Lund,et al.  Quantification for Staging Sinusitis , 1995 .

[74]  M. de Carli,et al.  Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. , 1992, Journal of immunology.