STUDIES ON THE EFFECT OF MATERNAL PRE‐ECLAMPTIC TOXAEMIA ON PLACENTAL WEIGHT AND ON HEAD SIZE AND BIRTH WEIGHT OF THE NEWBORN

The influence of pre‐eclamptic toxaemia (PET) on head size and birth weight of newborn infants and placental weight was studied in single live births after 35 to 42 weeks gestation from mothers with or without toxaemia. There were no significant differences in the distribution of mean birth weight, head size, placental weight, head size/birth weight ratio or placental weight/birth weight ratio between the toxaemic and non‐toxaemic groups. There were significant differences between toxaemic and non‐toxaemic mothers as regards parity, height and smoking habits. Since such maternal characteristics influence birth weights a correction was applied for them. The influence of maternal mid‐term weight and sex of the infants was also taken into account. No significant differences in corrected birth weights, between toxaemic and non‐toxaemic groups were detected on further analysis. It is suggested that the present obstetric management has prevented the retarding effect of pre‐eclamptic toxaemia on fetal and placental growth by reducing the severity and duration of the illness.

[1]  R. Milner,et al.  AN ANALYSIS OF BIRTH WEIGHT BY GESTATIONAL AGE OF INFANTS BORN IN ENGLAND AND WALES, 1967 TO 1971 , 1974, The Journal of obstetrics and gynaecology of the British Commonwealth.

[2]  B. Palmgren,et al.  Toxaemia and Cigarette Smoking During Pregnancy , 1973, Acta obstetricia et gynecologica Scandinavica.

[3]  P. Huttenlocher,et al.  Child development after pregnancies complicated by low urinary estriol excretion and pre-eclampsia. , 1972, American journal of obstetrics and gynecology.

[4]  E. Page ON THE PATHOGENESIS OF PRE‐ECLAMPSIA AND ECLAMPSIA * , 1972, The Journal of obstetrics and gynaecology of the British Commonwealth.

[5]  F. Schulte,et al.  Maternal toxemia, fetal malnutrition, and motor behavior of the newborn. , 1971, Pediatrics.

[6]  W. Billewicz,et al.  THE ASSESSMENT OF FETAL GROWTH , 1968, The Journal of obstetrics and gynaecology of the British Commonwealth.

[7]  I. Macgillivray,et al.  The incidence of pre-eclamptic toxaemia in smokers and non-smokers. , 1968, Lancet.

[8]  A. Chakravorty,et al.  FOETAL AND PLACENTAL WEIGHT CHANGES IN NORMAL PREGNANCY AND PRE‐ECLAMPSIA , 1967, The Journal of obstetrics and gynaecology of the British Commonwealth.

[9]  O'lane Jm,et al.  Parental smoking empirically related to pregnancy outcome. , 1967 .

[10]  R. Robinson Assessment of Gestational Age by Neurological Examination , 1966, Archives of disease in childhood.

[11]  R. Naeye Abnormalities in infants of mothers with toxemia of pregnancy. , 1966, American journal of obstetrics and gynecology.

[12]  P. Gruenwald Growth of the human fetus. II. Abnormal growth in twins and infants of mothers with diabetes, hypertension, or isoimmunization. , 1966, American journal of obstetrics and gynecology.

[13]  P. Gruenwald Chronic Fetal Distress and Placental Insufficiency (Part 1 of 3) , 1963 .

[14]  P. Beaudry,et al.  Birth weights of infants of toxemic mothers , 1960 .

[15]  T. Jeffcoate,et al.  SOME OBSERVATIONS ON THE PLACENTAL FACTOR IN PREGNANCY TOXEMIA , 1959, American journal of obstetrics and gynecology.

[16]  T. B. Fitzgerald,et al.  THE FŒTAL LOSS IN PREGNANCY TOXÆMIA , 1958 .

[17]  W. Billewicz,et al.  BIRTH WEIGHTS AND PLACENTAL WEIGHTS IN PRE‐ECLAMPSIA , 1957, The Journal of obstetrics and gynaecology of the British Empire.

[18]  S. Osborn,et al.  Effective circulation of the uterine wall in late pregnancy measured with 24NaCl. , 1955, Lancet.

[19]  A. A. Brash The Effect of Toxaemia of Pregnancy upon the Foetus and Newborn Child* , 1949, Archives of disease in childhood.

[20]  George Craig Ludlow INFANTS BORN OF WOMEN HAVING TOXEMIA AS A COMPLICATION OF PREGNANCY , 1933 .