Changes in premenstrual symptoms in women starting or discontinuing use of oral contraceptives

Abstract It is not clear whether oral contraceptive (OC) treatment affects premenstrual symptoms in women. The aim of the present study was to evaluate changes in premenstrual symptoms (PMS) in women starting to use or discontinuing the use of OCs. Twenty-four healthy women with no previous diagnosis of premenstrual dysphoric disorder were included in this study with a prospective crossover design. Nineteen women completed daily ratings of somatic and mood symptoms during two hormonally different cycles, during a normal menstrual cycle and while using OCs. The menstrual cycle phases were hormonally verified and the low-dose, monophasic OCs were used in a 21/7 regimen. The onset of OC use significantly decreased premenstrual somatic symptoms, but it did not affect mood symptoms. In the women who discontinued OC use, no significant changes in neither somatic nor mood symptoms appeared in the premenstrual phase.

[1]  Niklas Zethraeus,et al.  A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial. , 2017, Fertility and sterility.

[2]  Niklas Zethraeus,et al.  Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial. , 2016, The Journal of clinical endocrinology and metabolism.

[3]  A. Wiréhn,et al.  Continuation rates of oral hormonal contraceptives in a cohort of first-time users: a population-based registry study, Sweden 2005–2010 , 2013, BMJ Open.

[4]  S. Nyberg.  Mood and physical symptoms improve in women with severe cyclical changes by taking an oral contraceptive containing 250-mcg norgestimate and 35-mcg ethinyl estradiol. , 2013, Contraception.

[5]  E. Freeman,et al.  An overview of four studies of a continuous oral contraceptive (levonorgestrel 90 mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual syndrome. , 2012, Contraception.

[6]  J. Stanford,et al.  Characteristics of the menstrual cycle after discontinuation of oral contraceptives. , 2011, Journal of women's health.

[7]  A. Hirschberg,et al.  Postural control in women with premenstrual symptoms during oral contraceptive treatment , 2011, Acta obstetricia et gynecologica Scandinavica.

[8]  H. Doll,et al.  The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 μg of ethinyl estradiol , 2007 .

[9]  G. Bachmann,et al.  Treatment of premenstrual dysphoric disorder with a new drospirenone-containing oral contraceptive formulation. , 2005, Contraception.

[10]  Candace S. Brown,et al.  Efficacy of a New Low-Dose Oral Contraceptive With Drospirenone in Premenstrual Dysphoric Disorder , 2005, Obstetrics and gynecology.

[11]  K. Yonkers,et al.  Pretreatment pattern of symptom expression in premenstrual dysphoric disorder. , 2005, Journal of affective disorders.

[12]  G. Luscombe,et al.  Oral contraception and cyclic changes in premenstrual and menstrual experiences , 2003, Journal of psychosomatic obstetrics and gynaecology.

[13]  K. Rickels,et al.  Concurrent use of oral contraceptives with antidepressants for premenstrual syndromes. , 2001, Journal of clinical psychopharmacology.

[14]  S. Sanders,et al.  A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. , 2001, Contraception.

[15]  H. Sveinsdóttir,et al.  Menstrual cycle symptom variation in a community sample of women using and not using oral contraceptives , 2000, Acta obstetricia et gynecologica Scandinavica.

[16]  M. Bixo,et al.  Treatment of premenstrual syndrome with gonadotropin‐releasing hormone agonist in a low dose regimen , 1999, Acta obstetricia et gynecologica Scandinavica.

[17]  D. Rennie,et al.  The impact of oral contraceptives on the experience of perimenstrual mood, clumsiness, food craving and other symptoms. , 1993, Journal of psychosomatic research.

[18]  T. Bäckström,et al.  Oral contraceptives in premenstrual syndrome: a randomized comparison of triphasic and monophasic preparations. , 1992, Contraception.

[19]  B. Sherwin,et al.  A prospective treatment study of premenstrual symptoms using a triphasic oral contraceptive. , 1992, Journal of psychosomatic research.

[20]  S. Yen,et al.  The premenstrual syndrome. , 1983, Clinical obstetrics and gynecology.

[21]  Raymond Greene,et al.  The Premenstrual Syndrome , 1953, British Journal of Psychiatry.

[22]  L. Lopez,et al.  Oral contraceptives containing drospirenone for premenstrual syndrome. , 2009, The Cochrane database of systematic reviews.

[23]  H. Doll,et al.  The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 microg of ethinyl estradiol. , 2007, Contraception.

[24]  V. Birzniece,et al.  The Role of Hormones and Hormonal Treatments in Premenstrual Syndrome , 2003, CNS drugs.