COMPARISON OF SOME PROPERTIES OF PRONETHALOL AND PROPRANOLOL

Much evidence has accumulated to justify the classification of pronethalol (Alderlin : T.C.I.) as a sympathetic P-receptor antagonist described in terms of Ahlquist's (1948) dualreceptor hypothesis. There has now been confirmation in animal experiments of antagonism to adrenergically induced vasodilatation (Ahlquist, 1963 ; Abboud. Eckstein & Zimmerman. 1963), cardiac stimulation (Meester, Hardman & Barboriak, 1963 ; Kako, Krayenbuhl. Luthy & Hegglin, 1964 ; Donald, Kvale & Shepherd, 1964), bronchodilatation (Nagasaka, Schaepdryver & Heymans. 1964), uterine relaxation (Levy & Tozzi, 1963) and gut relaxation after block or loss of a-receptors (Lum & Kermani, 1963). In human pharmacological studies antagonism to catecholamine-induced vasodilatation and cardiac stimulation CDornhorst & Robinson, 1962 ; Lowe & Robinson, 1964) has been reported. Reduction of exercise tachycardia in man has been described by Bishop & Segel (1963). Chamberlain & Howard (1964). Harrison, Braunwald, Glick. Mason, Chidsey & Ross (1964) and SchrMer & Werko (1964). The effects of pronethalol in experimental cardiac arrhythmias in dogs and guinea-pigs have been investigated. Antagonism of arrhythmias induced by cardiac glycosides has been reported by Erlij & Mendes (1964). Vaughan-Williams & Sekiya (1963) and Somani, Hardman & Lum (1963). Prevention of arrhythmias induced by adrenaline during anaesthesia with a hydrocarbon has been found by Murray, McKnight & Davis (1963) and by Hess & Hampton (1964). Somani et al. (1963) have shown that pronethalol will block ectopic ventricular tachycardia produced by large doses of adrenaline, and Ehringer & Gogel (1963) claim that it reduces the apical myocardial necrosis produced in rats by large doses of isoprenaline. This interest in the cardiovascular actions of pronethalol is also shown in various clinical reports. Success in the treatment of some cardiac arrhythmias, including digitalis intoxication. has been reported by Stock & Dale (1963) and Grandjean & Rivier (1963). Encouraging results in the treatment of angina have been found in a multicentre doubleblind trial (Alleyne. Dickinson, Dornhorst, Fulton, Green, Hill, Hurst, Laurence, Pilkington, Prichard, Robinson & Rosenheim, 1963) and in a small, placebo-controlled, trial of effort tolerance (Apthorp, Chamberlain & Hayward, 1964). Potential therapeutic value of pronethalol in the management of phaeochromocytoma (Dornhorst & Laurence, 1963)

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