Multifunctional mesoporous silica nanocomposite nanoparticles for pH controlled drug release and dual modal imaging

Multifunctional nanocomposite nanoparticles for simultaneous fluorescence and magnetic resonance (MR) imaging, and pH-sensitive drug release were fabricated by immobilizing pH responsive hydrazone bonds, magnetite nanoparticles and fluorescent dyes in mesoporous silica nanoparticles. pH dependent release of doxorubicin was demonstrated and the nanocomposite nanoparticles show fluorescence emission and MR contrast effect.

[1]  Shih-Hsun Cheng,et al.  pH-controllable release using functionalized mesoporous silica nanoparticles as an oral drug delivery system , 2011 .

[2]  X. Qu,et al.  Polyvalent nucleic acid/mesoporous silica nanoparticle conjugates: dual stimuli-responsive vehicles for intracellular drug delivery. , 2011, Angewandte Chemie.

[3]  Chun-hua Lu,et al.  Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate. , 2011, Journal of the American Chemical Society.

[4]  C. Mou,et al.  Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics. , 2010, Angewandte Chemie.

[5]  Juan L. Vivero-Escoto,et al.  Mesoporous silica nanoparticles for intracellular controlled drug delivery. , 2010, Small.

[6]  Yu Chen,et al.  Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery. , 2010, ACS nano.

[7]  J. F. Stoddart,et al.  Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. , 2010, Journal of the American Chemical Society.

[8]  Zongxi Li,et al.  Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. , 2010, Small.

[9]  Fuyou Li,et al.  Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process. , 2010, Journal of the American Chemical Society.

[10]  J. Fraser Stoddart,et al.  Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. , 2010, Journal of the American Chemical Society.

[11]  Chin-Tu Chen,et al.  Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics—the trio of imaging, targeting and therapy , 2010 .

[12]  J. Eriksson,et al.  Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors. , 2010, Small.

[13]  Taeghwan Hyeon,et al.  Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. , 2010, Journal of the American Chemical Society.

[14]  L. J. Mueller,et al.  pH-responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker. , 2010, Journal of the American Chemical Society.

[15]  R. Martínez‐Máñez,et al.  Enzyme-responsive controlled release using mesoporous silica supports capped with lactose. , 2009, Angewandte Chemie.

[16]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[17]  T. Bein,et al.  Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica. , 2009, Angewandte Chemie.

[18]  Taeghwan Hyeon,et al.  Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. , 2009, Chemical Society reviews.

[19]  Chin-Tu Chen,et al.  Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution , 2009 .

[20]  Juan L. Vivero-Escoto,et al.  Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells. , 2009, Small.

[21]  Taeghwan Hyeon,et al.  Designed Fabrication of Silica‐Based Nanostructured Particle Systems for Nanomedicine Applications , 2008 .

[22]  Tao Wu,et al.  Tunable redox-responsive hybrid nanogated ensembles. , 2008, Journal of the American Chemical Society.

[23]  Ronald T Raines,et al.  Hydrolytic stability of hydrazones and oximes. , 2008, Angewandte Chemie.

[24]  J. Cheon,et al.  Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. , 2008, Accounts of chemical research.

[25]  R. Martínez‐Máñez,et al.  Dual aperture control on pH- and anion-driven supramolecular nanoscopic hybrid gate-like ensembles. , 2008, Journal of the American Chemical Society.

[26]  María Vallet-Regí,et al.  Mesoporous materials for drug delivery. , 2007, Angewandte Chemie.

[27]  Victor S-Y Lin,et al.  Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins. , 2007, Journal of the American Chemical Society.

[28]  V. S. Lin,et al.  Mesoporous silica nanoparticles deliver DNA and chemicals into plants. , 2007, Nature nanotechnology.

[29]  Jung Ho Yu,et al.  Generalized fabrication of multifunctional nanoparticle assemblies on silica spheres. , 2006, Angewandte Chemie.

[30]  R. Haag,et al.  Supramolecular drug-delivery systems based on polymeric core-shell architectures. , 2004, Angewandte Chemie.

[31]  Atsushi Harada,et al.  Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. , 2003, Angewandte Chemie.

[32]  Masahiro Fujiwara,et al.  Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica , 2003, Nature.

[33]  Anna Moore,et al.  In vivo magnetic resonance imaging of transgene expression , 2000, Nature Medicine.