PLASMAPHERESIS IN GOODPASTURE'S SYNDROME WITH RENAL FAILURE

Four patients who presented with severe proliferative glomerulonephritis associated with linear deposition of IgG on the basement membrane have been treated by intermittent massive plasmapheresis. Two patients had all the features of Goodpasture's syndrome. In the other two cases, the characteristic renal lesion was present but there was no pulmonary involvement. In all cases, renal function improved after plasmapheresis while in two, renal function deteriorated after plasmapheresis was stopped. One of these patients responded to a second course of plasmapheresis but failed to respond to a third.

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