Acute alcohol intoxication and cognitive functioning.

Acute alcohol intoxication produces changes in the cognitive functioning of normal individuals. These changes appear similar prima facie to those exhibited by individuals who sustain prefrontal lobe damage during adulthood. In order to test the validity of this observation, and to control for the confounding effects of expectancy, 72 male subjects were administered a battery of neuropsychological tests, within the context of a balanced-placebo design. Each subject received one of three widely different doses of alcohol. Analysis of the results of the cognitive test battery demonstrated that a high dose of alcohol detrimentally affects a number of functions associated with the prefrontal and temporal lobes, including planning, verbal fluency, memory and complex motor control. Expectancy does not appear to play a significant role in determining this effect. The implications of this pattern of impairment are analyzed and discussed.

[1]  Gabriel Leonard,et al.  Performance on unimanual and bimanual tapping tasks by patients with lesions of the frontal or temporal lobe , 1988, Neuropsychologia.

[2]  H. Barbaree,et al.  Alcohol and the balanced-placebo design: the role of experimenter demands in expectancy. , 1986, Journal of abnormal psychology.

[3]  B. Milner,et al.  Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man , 1982, Neuropsychologia.

[4]  J. Gray,et al.  Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system , 1982, Behavioral and Brain Sciences.

[5]  J. Hull.  A self-awareness model of the causes and effects of alcohol consumption. , 1981, Journal of abnormal psychology.

[6]  R. Seigel,et al.  Cerebral cortical atrophy in alcoholic men. , 1980, The Journal of clinical psychiatry.

[7]  R. Pihl,et al.  Self-control of the effects of alcohol intoxication. , 1980, Journal of studies on alcohol.

[8]  J. Bolter,et al.  Cerebral Damage Associated With Alcoholism: A Reexamination , 1980 .

[9]  R. Tarter,et al.  Effects of Task Complexity and Practice on Performance during Acute Alcohol Intoxication , 1971, Perceptual and motor skills.

[10]  A. Luria,et al.  Impaired selectivity of mental processes in association with a lesion of the frontal lobe , 1967 .

[11]  A. Luria,et al.  The programming of constructive activity in local brain injuries , 1964 .

[12]  Donald M. Johnson,et al.  Differential effects of alcohol on verbal fluency. , 1956, Quarterly journal of studies on alcohol.

[13]  S. Crown.  An Experimental Study of Psychological Changes Following Prefrontal Lobotomy , 1952 .

[14]  R. Mcfarland,et al.  Analysis of psychological experiments on the effects of alcohol. , 1940 .

[15]  B. Tabakoff,et al.  Ethanol’s Action on Brain Biochemistry , 1985 .

[16]  B. Milner,et al.  Psychological aspects of focal epilepsy and its neurosurgical management. , 1975, Advances in neurology.

[17]  S. D. Porteus.  The Maze Test and clinical psychology. , 1959 .