Going the distance with auxin: unravelling the molecular basis of auxin transport.

Auxin represents one of the most important classes of signalling molecules described in plants. Auxins regulate several fundamental cellular processes including division, elongation and differentiation. Indole-3-acetic acid (IAA), the principal form of auxin in higher plants, is first synthesized within young apical tissues, then conveyed to its basal target tissues by a specialized delivery system termed polar auxin transport. The polarity of IAA movement represents one of the most novel aspect of auxin signalling. IAA transport has been demonstrated to involve auxin influx and efflux carrier activities. The adoption of a mutational approach in the model plant Arabidopsis thaliana has led to the identification of a number of genes which encode components for, or regulate the activity of, the auxin transport machinery. This paper will review the advances being made in identifying and characterizing these auxin transport-related gene products and discuss their importance within the context of Arabidopsis development.

[1]  H. Fujita,et al.  PIS1, a negative regulator of the action of auxin transport inhibitors in Arabidopsis thaliana. , 1997, The Plant journal : for cell and molecular biology.

[2]  M. Estelle,et al.  Reduced naphthylphthalamic acid binding in the tir3 mutant of Arabidopsis is associated with a reduction in polar auxin transport and diverse morphological defects. , 1997, The Plant cell.

[3]  G. Muday,et al.  Cytoplasmic Orientation of the Naphthylphthalamic Acid-Binding Protein in Zucchini Plasma Membrane Vesicles , 1996, Plant physiology.

[4]  K. Feldmann,et al.  Arabidopsis AUX1 Gene: A Permease-Like Regulator of Root Gravitropism , 1996, Science.

[5]  F. Carland,et al.  LOP1: a gene involved in auxin transport and vascular patterning in Arabidopsis. , 1996, Development.

[6]  J. Reagan,et al.  The N-1-Naphthylphthalamic Acid-Binding Protein Is an Integral Membrane Protein , 1996, Plant physiology.

[7]  D. Söll,et al.  A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. , 1996, The EMBO journal.

[8]  C. Fischer,et al.  Influence of auxin on the establishment of bilateral symmetry in monocots , 1996 .

[9]  H. Nusbaum,et al.  Formation of lateral root meristems is a two-stage process. , 1995, Development.

[10]  J. Alvarez,et al.  Morphogenesis in pinoid mutants of Arabidopsis thaliana , 1995 .

[11]  G. Fink,et al.  A pathway for lateral root formation in Arabidopsis thaliana. , 1995, Genes & development.

[12]  G. Muday,et al.  NPA binding activity is peripheral to the plasma membrane and is associated with the cytoskeleton. , 1994, The Plant cell.

[13]  M. Estelle,et al.  Genetic approaches to auxin action. , 1994, Plant, cell & environment.

[14]  G. Muday,et al.  Tomato root growth, gravitropism, and lateral development: correlation with auxin transport. , 1994, Plant physiology and biochemistry : PPB.

[15]  W. Frommer,et al.  Expression cloning in yeast of a cDNA encoding a broad specificity amino acid permease from Arabidopsis thaliana. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[16]  N. Chua,et al.  Auxin Polar Transport Is Essential for the Establishment of Bilateral Symmetry during Early Plant Embryogenesis. , 1993, The Plant cell.

[17]  T. J. Cooke,et al.  Auxin levels at different stages of carrot somatic embryogenesis , 1992 .

[18]  T. Berleth,et al.  Mutations affecting body organization in the Arabidopsis embryo , 1991, Nature.

[19]  J. W. Wilson,et al.  Patterns of Tracheary Differentiation in Lettuce Pith Explants: Positional Control and Temperature Effects , 1991 .

[20]  C. Bell,et al.  Requirement of the Auxin Polar Transport System in Early Stages of Arabidopsis Floral Bud Formation. , 1991, The Plant cell.

[21]  D. Morris,et al.  Effects of Inhibitors of Protein Synthesis on Transmembrane Auxin Transport in Cucurbita pepo L. Hypocotyl Segments , 1991 .

[22]  P. Rubery,et al.  Naturally Occurring Auxin Transport Regulators , 1988, Science.

[23]  T. J. Cooke,et al.  Unusual patterns of somatic embryogenesis in the domesticated carrot: developmental effects of exogenous auxins and auxin transport inhibitors. , 1987, Cell differentiation.

[24]  T. Lomax,et al.  Active auxin uptake by zucchini membrane vesicles: quantitation using ESR volume and delta pH determinations. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[25]  G. Mitchison.  A model for vein formation in higher plants , 1980, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[26]  G. F. Katekar,et al.  Auxin Transport Inhibitors: III. Chemical Requirements of a Class of Auxin Transport Inhibitors. , 1977, Plant physiology.

[27]  M. Goldsmith,et al.  The Polar Transport of Auxin , 1977 .

[28]  John A. Raven,et al.  TRANSPORT OF INDOLEACETIC ACID IN PLANT CELLS IN RELATION TO pH AND ELECTRICAL POTENTIAL GRADIENTS, AND ITS SIGNIFICANCE FOR POLAR IAA TRANSPORT , 1975 .

[29]  P. Benfey,et al.  Organization and cell differentiation in lateral roots of Arabidopsis thaliana. , 1997, Development.

[30]  D. Bush.  Proton-Coupled Sugar and Amino Acid Transporters in Plants , 1993 .

[31]  T. Sachs.  The Control of the Patterned Differentiation of Vascular Tissues , 1981 .