[11C]acetate PET/CT Visualizes Skeletal Muscle Exercise Participation, Impaired Function, and Recovery after Hip Arthroplasty; First Results

PurposeBased on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [11C]acetate PET.ProceduresTwo male patients were investigated 3 and 12 weeks after hip arthroplasty with muscle [11C]acetate PET/CT performed at rest and exercise. Median muscle SUVmean were calculated on three non-consecutive transverse PET slices.ResultsThe four exercise PET/CT showed, compared with rest, consistent increase in [11C]acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12 weeks after surgery, but four muscles showed only minor activity increase at 3 weeks. At 3 months, functional recovery of the latter four muscles was observed.ConclusionConsistent increase in [11C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation.

[1]  M. Krempf,et al.  Kinetic aspects of acetate metabolism in healthy humans using [1-13C] acetate. , 1996, The American journal of physiology.

[2]  M. Sacchetti,et al.  Whole body and leg acetate kinetics at rest, during exercise and recovery in humans , 2002, The Journal of physiology.

[3]  S. Nekolla,et al.  Oxidative metabolism of the transplanted human heart assessed by positron emission tomography using C-11 acetate. , 1999, The American journal of cardiology.

[4]  H. Okazawa,et al.  Simple quantification of myocardial perfusion by pixel-by-pixel graphical analysis using carbon-11 acetate: comparison of the K-complexes of carbon-11 acetate and nitrogen-13 ammonia , 2008, Nuclear medicine communications.

[5]  Claude Comtat,et al.  Preserving Poisson characteristics of PET data with weighted OSEM reconstruction , 1998, 1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255).

[6]  Heikki Kyröläinen,et al.  Skeletal muscle blood flow and flow heterogeneity during dynamic and isometric exercise in humans. , 2003, American journal of physiology. Heart and circulatory physiology.

[7]  L. Sidossis,et al.  Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies. , 1995, The Journal of clinical investigation.

[8]  M. Schwaiger,et al.  Acute effects of dobutamine on myocardial oxygen consumption and cardiac efficiency measured using carbon-11 acetate kinetics in patients with dilated cardiomyopathy. , 1993, Journal of the American College of Cardiology.

[9]  Claudio Dora,et al.  Abductor tendons and muscles assessed at MR imaging after total hip arthroplasty in asymptomatic and symptomatic patients. , 2005, Radiology.

[10]  Mohamed Allaoua,et al.  Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose. , 2004, International journal of radiation oncology, biology, physics.

[11]  M Schwaiger,et al.  Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  C. Ng,et al.  Validation of a model for [1-11C]acetate as a tracer of cardiac oxidative metabolism. , 1994, The American journal of physiology.

[13]  P. Paul,et al.  Plasma acetate turnover and oxidation. , 1979, The Journal of clinical investigation.

[14]  D. Soloviev,et al.  Captive solvent [11C]acetate synthesis in GMP conditions. , 2006, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[15]  Tuula Tolvanen,et al.  Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data , 2001, European Journal of Nuclear Medicine.

[16]  D. Ilstrup,et al.  Total hip arthroplasty. , 1978, The Journal of bone and joint surgery. American volume.

[17]  C. Perka,et al.  Randomized controlled trial of abductor muscle damage in relation to the surgical approach for primary total hip replacement: minimally invasive anterolateral versus modified direct lateral approach , 2011, Archives of Orthopaedic and Trauma Surgery.

[18]  I. Matsunari,et al.  11C-acetate PET imaging of lung cancer: comparison with 18F-FDG PET and 99mTc-MIBI SPET , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[19]  E W Olcott,et al.  Imaging of skeletal muscle function using (18)FDG PET: force production, activation, and metabolism. , 2001, Journal of applied physiology.

[20]  M E Phelps,et al.  Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography. , 1989, Circulation.

[21]  J. Knuuti,et al.  Myocardial and skeletal muscle glucose uptake during exercise in humans , 2002, The Journal of physiology.

[22]  J. M. Ollinger,et al.  Positron Emission Tomography , 2018, Handbook of Small Animal Imaging.

[23]  A. Buck,et al.  An approach to ventricular efficiency by use of carbon 11-labeled acetate and positron emission tomography , 1994, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[24]  H R Schelbert,et al.  Validation of [1-11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. , 1990, Circulation.

[25]  S. Kokubun,et al.  Muscle activity during a dash shown by 18F-fluorodeoxyglucose positron emission tomography , 2006, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[26]  D. Chinkes,et al.  Regional acetate kinetics and oxidation in human volunteers. , 1998, The American journal of physiology.

[27]  Mel S. Lee.  Minimally invasive total hip arthroplasty. , 2012, Clinical privilege white paper.