Further studies on inhibition and adaptation of a parental tumor in F1 hybrid mice.

Growth repression of a parental tumor in F1 hybrid mice and adaptation of the tumor to such repression were further studied with the 21B lymphoma of C57BL mice. With a tumor line propagated only in C57BL mice, growth repression in F1 hybrids was found to depend more on heterozygosity of the hybrid at the H-2 locus than on heterozygosity at other loci. Passage of the tumor in F1 hybrid hosts facilitated its subsequent growth in those specific hosts under certain circumstances. This adaptation was lost after passage of the modified tumor through F1 hosts other than those to which adaptation had been induced. The adaptation of a tumor to a hybrid containing certain H-2 antigens did not favor its growth in a genetically different hybrid containing the same H-2 antigens. The results are interpreted in terms of a discontinuity between recognition of, and response to, tumor-specific antigens of parental cells.

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