Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations

Nanotechnology has emerged as one of the leading fields of the science having tremendous application in diverse disciplines. As nanomaterials are increasingly becoming part of everyday consumer products, it is imperative to assess their impact on living organisms and on the environment. Physicochemical characteristics of nanoparticles and engineered nanomaterials including size, shape, chemical composition, physiochemical stability, crystal structure, surface area, surface energy, and surface roughness generally influence the toxic manifestations of these nanomaterials. This compels the research fraternity to evaluate the role of these properties in determining associated toxicity issues. Reckoning with this fact, in this paper, issues pertaining to the physicochemical properties of nanomaterials as it relates to the toxicity of the nanomaterials are discussed.

[1]  Claire Raison.  Gold nanoparticle-based diagnostic test for rapid diagnosis of leading infectious diseases. , 2013, Expert review of molecular diagnostics.

[2]  Huibi Xu,et al.  Probing the cytotoxicity of CdSe quantum dots with surface modification , 2007 .

[3]  Yahya E Choonara,et al.  Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors , 2014, International journal of nanomedicine.

[4]  Vincent M Rotello,et al.  Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. , 2004, Bioconjugate chemistry.

[5]  Feng Zhao,et al.  Acute toxicological effects of copper nanoparticles in vivo. , 2006, Toxicology letters.

[6]  Chong-Kook Kim,et al.  Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles. , 2007, Biomaterials.

[7]  Jiwon Bang,et al.  Spectral Switching of Type-II Quantum Dots by Charging , 2009 .

[8]  Stephen T Holgate,et al.  Exposure, uptake, distribution and toxicity of nanomaterials in humans. , 2010, Journal of biomedical nanotechnology.

[9]  Sung Tae Kim,et al.  Dendronized gold nanoparticles for siRNA delivery. , 2012, Small.

[10]  W. Stark,et al.  The degree and kind of agglomeration affect carbon nanotube cytotoxicity. , 2007, Toxicology letters.

[11]  Alexander Eychmüller,et al.  Type-I and type-II nanoscale heterostructures based on CdTe nanocrystals: a comparative study. , 2008, Small.

[12]  Michael J Sailor,et al.  Biodegradable luminescent porous silicon nanoparticles for in vivo applications. , 2009, Nature materials.

[13]  Jean-Marie Lehn,et al.  Toward Self-Organization and Complex Matter , 2002, Science.

[14]  P. Candeloro,et al.  Water soluble nanoporous nanoparticle for in vivo targeted drug delivery and controlled release in B cells tumor context. , 2010, Nanoscale.

[15]  Christy L Haynes,et al.  Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity. , 2010, Journal of the American Chemical Society.

[16]  Vincent Castranova,et al.  Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity , 2007 .

[17]  J. West,et al.  The Differential Cytotoxicity of Water-Soluble Fullerenes , 2004 .

[18]  G. Reiners.  Corrosion Books: Handbook of Thin Film Deposition ‐ Processes and Techniques, Principles, Methods, Equipment and Applications. By K. Seshan ‐ Materials and Corrosion 10/2002 , 2002 .

[19]  P. Baron,et al.  Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[20]  Carlo Petrini,et al.  Informed consent in experimentation involving mentally impaired persons: ethical issues. , 2010, Annali dell'Istituto superiore di sanita.

[21]  M Volante,et al.  Chemical functionalities at the silica surface determining its reactivity when inhaled. Formation and reactivity of surface radicals. , 1990, Toxicology and industrial health.

[22]  Samir Mitragotri,et al.  Role of target geometry in phagocytosis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Pratim Biswas,et al.  Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies , 2009 .

[24]  S. Doak,et al.  NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. , 2009, Biomaterials.

[25]  Ande Bao,et al.  Dynamic Imaging of Functionalized Multi‐Walled Carbon Nanotube Systemic Circulation and Urinary Excretion , 2008 .

[26]  Chen-Yuan Dong,et al.  Studies of intracorneal distribution and cytotoxicity of quantum dots: risk assessment of eye exposure. , 2011, Chemical research in toxicology.

[27]  Yuh-Jeen Huang,et al.  Effects of various physicochemical characteristics on the toxicities of ZnO and TiO nanoparticles toward human lung epithelial cells. , 2011, The Science of the total environment.

[28]  Tim Liedl,et al.  Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. , 2005, Nano letters.

[29]  Jing Luo,et al.  Effects of particle composition and species on toxicity of metallic nanomaterials in aquatic organisms , 2008, Environmental toxicology and chemistry.

[30]  Nastassja A. Lewinski,et al.  Cytotoxicity of nanoparticles. , 2008, Small.

[31]  N. Wu,et al.  Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity , 2009, Particle and Fibre Toxicology.

[32]  Helinor J Johnston,et al.  A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity , 2010, Critical reviews in toxicology.

[33]  Y. Hung,et al.  Assessment of the In Vivo Toxicity of Gold Nanoparticles , 2009, Nanoscale research letters.

[34]  Rainer H. Müller,et al.  Alkylcyanoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length , 1992 .

[35]  T. Xia,et al.  Understanding biophysicochemical interactions at the nano-bio interface. , 2009, Nature materials.

[36]  Federica Valentini,et al.  Low doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic development. , 2011, ACS nano.

[37]  Vicki Stone,et al.  Current hypotheses on the mechanisms of toxicity of ultrafine particles. , 2003, Annali dell'Istituto superiore di sanita.

[38]  Petra Krystek,et al.  Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. , 2008, Biomaterials.

[39]  Feng Zhao,et al.  Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles. , 2007, Toxicology letters.

[40]  Ajay Kumar Gupta,et al.  Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. , 2005, Biomaterials.

[41]  Chi‐Hwa Wang,et al.  Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[42]  Abbas S. Milani,et al.  Synthesis, surface architecture and biological response of superparamagnetic iron oxide nanoparticles for application in drug delivery: a review , 2010 .

[43]  Hassan S. Bazzi,et al.  Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots , 2005, Journal of Molecular Medicine.

[44]  星野 昭芳,et al.  Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification , 2008 .

[45]  Anthony Seaton,et al.  Nanoscience, nanotoxicology, and the need to think small , 2005, The Lancet.

[46]  Bryant C Nelson,et al.  Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA , 2010, Analytical and bioanalytical chemistry.

[47]  Daniele Gerion,et al.  Fluorescent CdSe/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and , 2004 .

[48]  K. Seshan,et al.  Handbook of Thin Film Deposition Processes and Techniques: Principles, Methods, Equipment and Applications , 2001 .

[49]  Steffen Loft,et al.  Oxidative stress-induced DNA damage by particulate air pollution. , 2005, Mutation research.

[50]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[51]  W. Heideman,et al.  Developmental toxicity of low generation PAMAM dendrimers in zebrafish. , 2007, Toxicology and applied pharmacology.

[52]  Ivana Fenoglio,et al.  Effect of chemical composition and state of the surface on the toxic response to high aspect ratio nanomaterials. , 2011, Nanomedicine.

[53]  Mira Josowicz,et al.  Composites of intrinsically conducting polymers as sensing nanomaterials. , 2008, Chemical reviews.

[54]  Silvana Andreescu,et al.  Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish. , 2009, Environmental science & technology.

[55]  Francesco Stellacci,et al.  Effect of surface properties on nanoparticle-cell interactions. , 2010, Small.

[56]  I. Zuhorn,et al.  Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[57]  D. Xing,et al.  Ultrasensitive aptamer-based bio bar code immunomagnetic separation and electrochemiluminescence method for the detection of protein. , 2012, Analytica chimica acta.

[58]  Shuming Nie,et al.  Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo. , 2008, Journal of the American Chemical Society.

[59]  Haifang Wang,et al.  Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. , 2008, Toxicology letters.

[60]  John Archdeacon,et al.  A non-covalent peptide-based carrier for in vivo delivery of DNA mimics , 2007, Nucleic acids research.

[61]  Craig A. Poland,et al.  Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. , 2008, Nature nanotechnology.

[62]  Claire Raison.  Preterm birth risk diagnostic test to be given boost by partnership between Agilent Technologies and Sera Prognostics. , 2013, Expert review of molecular diagnostics.

[63]  K. Schuegraf,et al.  Handbook of thin-film deposition processes and techniques : principles, methods, equipment, and applications , 1988 .

[64]  H. Too,et al.  The effects of particle size and surface coating on the cytotoxicity of nickel ferrite. , 2005, Biomaterials.

[65]  Bahman Asgharian,et al.  Deposition of Ultrafine (NANO) Particles in the Human Lung , 2007, Inhalation toxicology.

[66]  Chad A Mirkin,et al.  Multiplexed nanoflares: mRNA detection in live cells. , 2012, Analytical chemistry.

[67]  Zafar Iqbal,et al.  Single-walled Carbon Nanotubes Are a New Class of Ion Channel Blockers* , 2003, Journal of Biological Chemistry.

[68]  J. Banfield,et al.  Water-driven structure transformation in nanoparticles at room temperature , 2003, Nature.

[69]  Stephen M. Roberts,et al.  Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies , 2007 .

[70]  H. Alpár,et al.  Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge. , 2004, International journal of pharmaceutics.

[71]  Noritada Kaji,et al.  Nanobiodevices for biomolecule analysis and imaging. , 2013, Annual review of analytical chemistry.

[72]  Arezou A Ghazani,et al.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. , 2006, Nano letters.

[73]  C. Murphy,et al.  Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. , 2005, Small.

[74]  K. Jan,et al.  Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. , 2005, Toxicology.

[75]  Taeghwan Hyeon,et al.  Applications of inorganic nanoparticles as therapeutic agents , 2014, Nanotechnology.

[76]  V. Colvin.  The potential environmental impact of engineered nanomaterials , 2003, Nature Biotechnology.

[77]  Claire Raison.  NanoString® launches its first commercial diagnostic product. , 2013, Expert review of molecular diagnostics.

[78]  M Laird Forrest,et al.  Effects of nanomaterial physicochemical properties on in vivo toxicity. , 2009, Advanced drug delivery reviews.

[79]  Sourav Bhattacharjee,et al.  Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells , 2010, Particle and Fibre Toxicology.

[80]  Ignacy Gryczynski,et al.  Metal-enhanced fluorescence: an emerging tool in biotechnology. , 2005, Current opinion in biotechnology.

[81]  Lang Tran,et al.  Safe handling of nanotechnology , 2006, Nature.

[82]  Paul Westerhoff,et al.  Biological accumulation of engineered nanomaterials: a review of current knowledge. , 2013, Environmental science. Processes & impacts.

[83]  M Lippmann,et al.  Effects of fiber characteristics on lung deposition, retention, and disease. , 1990, Environmental health perspectives.

[84]  Parag Aggarwal,et al.  Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. , 2009, Advanced drug delivery reviews.

[85]  W. Kreyling,et al.  TRANSLOCATION OF ULTRAFINE INSOLUBLE IRIDIUM PARTICLES FROM LUNG EPITHELIUM TO EXTRAPULMONARY ORGANS IS SIZE DEPENDENT BUT VERY LOW , 2002, Journal of toxicology and environmental health. Part A.