Effect of administration of a combined estrogen-progestin contraceptive on the level of individual plasma proteins.

Serum proteins of 30 women were estimated before, and 6 months after, regular intake of contraceptive pills (0.1 mg mestranol and 5 mg megestrol). A highly significant rise of increasing degree was observed for α2-macroglobulin, lipoproteins, transferrin, plasminogen, α1-antitrypsin, thyroxine-binding globulin (cortisol), and ceruloplasmin. The immunoglobulins were unchanged, but albumin, haptoglobins, and orosomucoid showed a highly significant decrease. The fall of orosomucoid and haptoglobins was greater than during pregnancy, while the rise of α1-antitrypsin, α2-macroglobulin, lipoproteins, and transferrin was less. It is concluded that the metabolic effects of contraceptive steroids has not been properly explored. This study implies that these metabolic effects are only in partial agreement with the alterations occurring during normal pregnancy.

[1]  C. Laurell.  Orosomucoid and alpha 1-antitrypsin in maternal and fetal sera at parturition. , 1968, Scandinavian journal of clinical and laboratory investigation.

[2]  J. Zilva,et al.  Effect of oral contraceptives on the variations in serum-iron during the menstrual cycle. , 1967, Lancet.

[3]  A. Kappas,et al.  The effects of estradiol and estriol on plasma levels of cortisol and thyroid hormone-binding globulins and on aldosterone and cortisol secretion rates in man. , 1967, The Journal of clinical investigation.

[4]  U. Seal,et al.  Serum protein alterations produced in women by synthetic estrogens. , 1967, The Journal of clinical endocrinology and metabolism.

[5]  R. W. Robinson.  Effect of estrogen-progestin combinations on clotting factors. , 1967, American journal of obstetrics and gynecology.

[6]  G. T. Mellinger,et al.  Estrogen dosage effects on serum proteins: a longitudinal study. , 1967, The Journal of clinical endocrinology.

[7]  J. Burton.  Effect of oral contraceptives on haemoglobin, packed-cell volume, serum-iron, and total iron-binding capacity in healthy women. , 1967, Lancet.

[8]  G. S. Robertson.  Serum protein and cholinesterase changes in association with contraceptive pills. , 1967, Lancet.

[9]  J. Starup,et al.  The Coagulation Mechanism in Oral Contraception , 1967 .

[10]  B. Bjerre,et al.  α1‐Antitrypsin and α2‐Macroglobulin Concentration in Serum During Pregnancy , 1967, Acta Obstetricia et Gynecologica Scandinavica.

[11]  S. Kullander,et al.  Coagulation And Fibrinolytic Studies During Use Of Gestagens , 1967, Acta obstetricia et gynecologica Scandinavica.

[12]  D. Dimov,et al.  A new useful modification for the determination of γ-glutamyltranspeptidase activity , 1966 .

[13]  V. Wynn,et al.  Some effects of oral contraceptives on serum-lipid and lipoprotein levels. , 1966, Lancet.

[14]  M E Carruthers,et al.  Raised serum copper and caeruloplasmin levels in subjects taking oral contraceptives , 1966, Journal of clinical pathology.

[15]  L. Poller,et al.  Clotting Factors during Oral Contraception: Further Report , 1966, British medical journal.

[16]  C. Laurell,et al.  Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. , 1966, Analytical biochemistry.

[17]  P. H. Tarukoski.  Quantitative spectrophotometric determination of haptoglobin. , 1966, Scandinavian journal of clinical and laboratory investigation.

[18]  P. D. de Moor,et al.  Data on transcortin activity in human plasma as studied by gel filtration. , 1966, The Journal of clinical endocrinology and metabolism.

[19]  V. Drill.  ENDOCRINE PROPERTIES AND LONG-TERM SAFETY OF ORAL CONTRACEPTIVES. , 1965, Metabolism: clinical and experimental.

[20]  J. Hamilton,et al.  USE OF AGAR GEL ELECTROPHORESIS AND AUTORADIOGRAPHY TO MEASURE THYROXINE-BINDING PROTEIN CAPACITIES. , 1964, The Journal of laboratory and clinical medicine.

[21]  S. Liao,et al.  TESTICULAR HORMONES AND THE SYNTHESIS OF RIBONUCLEIC ACIDS AND PROTEINS IN THE PROSTATE GLAND. , 1964, Recent progress in hormone research.

[22]  C. Laurell,et al.  Estrogens and Plasma Orosomucoid , 1963 .

[23]  P. D. de Moor,et al.  The specificity of fluorometric corticoid determinations. , 1962, Clinica chimica acta; international journal of clinical chemistry.

[24]  N. Zöllner,et al.  Über die quantitative Bestimmung von Lipoiden (Mikromethode) mittels der vielen natürlichen Lipoiden (allen bekannten Plasmalipoiden) gemeinsamen Sulfophosphovanillin-Reaktion , 1962 .

[25]  A. Sandberg,et al.  Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effects of estrogens. , 1959, The Journal of clinical investigation.

[26]  A. Sandberg,et al.  Transcortin: a corticosteroid-binding protein of plasma. , 1959, The Journal of clinical investigation.

[27]  N. Freinkel,et al.  Effect of diethylstilbestrol on the binding of thyroxine in serum. , 1956, The Journal of clinical endocrinology and metabolism.

[28]  N. Freinkel,et al.  Thyroxine-binding by sera of pregnant women. , 1956, The Journal of clinical endocrinology and metabolism.

[29]  H. Eder,et al.  Influence of gonadal hormones on protein-lipid relationships in human plasma. , 1955, The American journal of medicine.

[30]  W. Studnitz.  Studies on serum lipids and lipoproteins in pregnancy. , 1955 .

[31]  H. Eder,et al.  Protein-lipid relationships in human plasma. III. In pregnancy and the newborn. , 1954, The Journal of clinical investigation.

[32]  O. Hornykiewicz,et al.  [Effect of sex hormones of the p-polyphenoloxidase activity of the human blood serum]. , 1954, Archiv fur Gynakologie.

[33]  G. Cartwright,et al.  STUDIES ON FREE ERYTHROCYTE PROTOPORPHYRIN, SERUM IRON, SERUM IRON-BINDING CAPACITY AND PLASMA COPPER DURING NORMAL PREGNANCY. , 1949, The Journal of clinical investigation.

[34]  C. Laurell.  Studies on the transportation and metabolism of iron in the body with special reference to the iron-binding component in human plasma. , 1947 .

[35]  A. Schulerud.  The contents of phytic acid P in Norwegian flour and bread types; factors influencing phytic acid decomposition during breadmaking and the contents of phytic acid P in ordinary Norwegian bread. , 1947, Acta physiologica Scandinavica.

[36]  C. Lagercrantz.  Electrophoretic analysis of serum in pregnancy and in pregnancy toxemia. , 1945, Upsala lakareforenings forhandlingar.