Targeting the Hedgehog pathway in cancer

[1]  D. Murrell,et al.  A comparative study between electron microscopy and immunofluorescence mapping in the diagnosis of epidermolysis bullosa , 2006 .

[2]  Qian Wang,et al.  Activation of the hedgehog pathway in human hepatocellular carcinomas. , 2006, Carcinogenesis.

[3]  G. Dontu,et al.  Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. , 2006, Cancer research.

[4]  L. Rubin,et al.  The hedgehog pathway and neurological disorders. , 2006, Annual review of neuroscience.

[5]  Wei Zhang,et al.  Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. , 2006, Developmental cell.

[6]  Toyoaki Tenzen,et al.  The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. , 2006, Developmental cell.

[7]  L. Lum,et al.  The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation , 2006, Cell.

[8]  T. Curran,et al.  Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. , 2006, Cancer research.

[9]  A. Navarro,et al.  Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients. , 2006, Cancer letters.

[10]  M. Lauth,et al.  Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. , 2006, Developmental cell.

[11]  L. Kindblom,et al.  Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development , 2006, The Journal of pathology.

[12]  K. Anderson,et al.  Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates , 2006, Development.

[13]  B. Alman,et al.  Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. , 2006, The American journal of pathology.

[14]  Johan Ericson,et al.  Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. , 2005, Developmental biology.

[15]  Didier Y. R. Stainier,et al.  Vertebrate Smoothened functions at the primary cilium , 2005, Nature.

[16]  K. Anderson,et al.  Cilia and Hedgehog responsiveness in the mouse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Blaise Lippa,et al.  The Hedgehog signaling pathway as a target for anticancer drug discovery. , 2005, Current topics in medicinal chemistry.

[18]  G. Dontu,et al.  Mammary stem cells, self-renewal pathways, and carcinogenesis , 2005, Breast Cancer Research.

[19]  Hans Clevers,et al.  Self-Renewal and Cancer of the Gut: Two Sides of a Coin , 2005, Science.

[20]  P. Sánchez,et al.  In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice , 2005, Mechanisms of Development.

[21]  Alan Carleton,et al.  Sonic hedgehog controls stem cell behavior in the postnatal and adult brain , 2005, Development.

[22]  David M. Berman,et al.  Tissue repair and stem cell renewal in carcinogenesis , 2004, Nature.

[23]  Xiao-li Zhang,et al.  Inhibition of Smoothened Signaling Prevents Ultraviolet B-Induced Basal Cell Carcinomas through Regulation of Fas Expression and Apoptosis , 2004, Cancer Research.

[24]  Frank McCormick,et al.  Activation of the hedgehog pathway in advanced prostate cancer , 2004, Molecular Cancer.

[25]  Andrew P. Weng,et al.  Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.

[26]  M. Clarke,et al.  Self-renewal and solid tumor stem cells , 2004, Oncogene.

[27]  Helen Baines,et al.  Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. , 2004, Cancer cell.

[28]  Masatoshi Nomura,et al.  Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer , 2004, Cancer Research.

[29]  M. Datta,et al.  Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[30]  G. Dontu,et al.  Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells , 2004, Breast Cancer Research.

[31]  A. Oniscu,et al.  Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia , 2004, The Journal of pathology.

[32]  J. Thrasher,et al.  Hedgehog signaling promotes prostate xenograft tumor growth. , 2004, Endocrinology.

[33]  A. C. Williams,et al.  Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment , 2004, International journal of cancer.

[34]  Bob Y. Liu,et al.  The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  O. Avcı,et al.  Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity. , 2004, European journal of dermatology : EJD.

[36]  William Gaffield,et al.  Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation , 2004, Nature Genetics.

[37]  V. Palma,et al.  Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex , 2003, Development.

[38]  A. Maitra,et al.  Urological Survey UROLOGICAL ONCOLOGY: PROSTATE CANCER Hedgehog Signalling in Prostate Regeneration, Neoplasia and Metastasis , 2005 .

[39]  Lee Niswander,et al.  Hedgehog signalling in the mouse requires intraflagellar transport proteins , 2003, Nature.

[40]  Gregory Y. Lauwers,et al.  Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis , 2003, Nature.

[41]  Yutaka Shimada,et al.  Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours , 2003, Nature.

[42]  Andrew P. McMahon,et al.  Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches , 2003, Neuron.

[43]  H. Wichterle,et al.  Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[44]  B. Alman,et al.  Developmental Pathways in Musculoskeletal Neoplasia: Involvement of the Indian Hedgehog-Parathyroid Hormone-Related Protein Pathway , 2003, Pediatric Research.

[45]  Stephen B. Baylin,et al.  Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer , 2003, Nature.

[46]  K. Allendoerfer,et al.  Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. , 2003, The Journal of clinical investigation.

[47]  Fred H. Gage,et al.  Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo , 2003, Nature Neuroscience.

[48]  H. Wichterle,et al.  Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists , 2002, Journal of biology.

[49]  Jussi Taipale,et al.  Small molecule modulation of Smoothened activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[50]  James M. Olson,et al.  Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade , 2002, Science.

[51]  Wei Du,et al.  Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E , 2002, Nature.

[52]  David Hogg,et al.  Mutations in SUFU predispose to medulloblastoma , 2002, Nature Genetics.

[53]  H. Weiner,et al.  The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. , 2001, Development.

[54]  P. Ingham,et al.  Hedgehog signaling in animal development: paradigms and principles. , 2001, Genes & development.

[55]  Takayuki Asahara,et al.  The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors , 2001, Nature Medicine.

[56]  A. McMahon,et al.  Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. , 2001, The Journal of clinical investigation.

[57]  D. Melton,et al.  Regulation of pancreas development by hedgehog signaling. , 2000, Development.

[58]  D. Kalderon Transducing the Hedgehog Signal , 2000, Cell.

[59]  M. Scott,et al.  Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine , 2000, Nature.

[60]  S. Cohen,et al.  Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened , 2000, Cell.

[61]  D. Krause,et al.  Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[62]  C. Hui,et al.  Basal cell carcinomas in mice overexpressing Gli2 in skin , 2000, Nature Genetics.

[63]  M. Scott,et al.  Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice , 1999, Nature Medicine.

[64]  A. McMahon,et al.  Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. , 1999, Genes & development.

[65]  Soheila Sharghi Namini,et al.  Schwann Cell–Derived Desert Hedgehog Controls the Development of Peripheral Nerve Sheaths , 1999, Neuron.

[66]  A. Ruiz i Altaba,et al.  Sonic hedgehog regulates the growth and patterning of the cerebellum. , 1999, Development.

[67]  V. Wallace Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum , 1999, Current Biology.

[68]  A. McMahon,et al.  Schwann cell-derived desert hedgehog signals nerve sheath formation. , 1999, Annals of the New York Academy of Sciences.

[69]  M. Scott,et al.  Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog , 1999, Neuron.

[70]  A. McMahon,et al.  Sonic hedgehog regulates branching morphogenesis in the mammalian lung , 1998, Current Biology.

[71]  M. Wolter,et al.  Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. , 1998, Cancer research.

[72]  Q. Gu,et al.  Activating Smoothened mutations in sporadic basal-cell carcinoma , 1998, Nature.

[73]  N. Dahmane,et al.  Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours , 1997, Nature.

[74]  A. R. I. Altaba Catching a Gli-mpse of Hedgehog , 1997, Cell.

[75]  T. Kornberg,et al.  Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor , 1997, Cell.

[76]  M. Ståhle-Bäckdahl,et al.  Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. , 1997, Cancer research.

[77]  M. Scott,et al.  Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. , 1997, Cancer research.

[78]  M. Scott,et al.  Basal cell carcinomas in mice overexpressing sonic hedgehog. , 1997, Science.

[79]  C. James,et al.  Sporadic medulloblastomas contain PTCH mutations. , 1997, Cancer research.

[80]  B. Hogan,et al.  Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. , 1997, Development.

[81]  S. Scherer,et al.  Mutations in the human Sonic Hedgehog gene cause holoprosencephaly , 1996, Nature Genetics.

[82]  Michael Dean,et al.  Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome , 1996, Cell.

[83]  R. Myers,et al.  Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome , 1996, Science.

[84]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.