Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

[1]  J. Weissman,et al.  Differential Scales of Protein Quality Control , 2014, Cell.

[2]  Christoph Steinbeck,et al.  Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links , 2014, PLoS genetics.

[3]  J. Auwerx,et al.  The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease , 2014, Journal of Experimental Biology.

[4]  Jonathan K. Pritchard,et al.  Primate Transcript and Protein Expression Levels Evolve Under Compensatory Selection Pressures , 2013, Science.

[5]  Wangyang Xu,et al.  DHTKD1 is essential for mitochondrial biogenesis and function maintenance , 2013, FEBS letters.

[6]  R. Vasan,et al.  2-Aminoadipic acid is a biomarker for diabetes risk. , 2013, The Journal of clinical investigation.

[7]  Vivien Marx,et al.  Finding the right antibody for the job , 2013, Nature Methods.

[8]  L. Kruglyak,et al.  Genetics of single-cell protein abundance variation in large yeast populations , 2013, Nature.

[9]  Cole M. Haynes,et al.  Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. , 2013, Trends in cell biology.

[10]  William Stafford Noble,et al.  Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast , 2013, Genome research.

[11]  Robert W. Williams,et al.  Mitonuclear protein imbalance as a conserved longevity mechanism , 2013, Nature.

[12]  G. Morahan,et al.  A novel mechanism regulating insulin secretion involving Herpud1 in mice , 2013, Diabetologia.

[13]  M. Baumgartner,et al.  Genetic basis of hyperlysinemia , 2013, Orphanet Journal of Rare Diseases.

[14]  Shu Liu,et al.  Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response , 2013, PLoS genetics.

[15]  M. Kostrzewa,et al.  Quantitative Trait Loci Mapping of the Mouse Plasma Proteome (pQTL) , 2013, Genetics.

[16]  Eric W. Deutsch,et al.  A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis , 2013, Nature.

[17]  T. Wieland,et al.  DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria. , 2012, American journal of human genetics.

[18]  Jianfang Ma,et al.  A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. , 2012, American journal of human genetics.

[19]  David S. Wishart,et al.  HMDB 3.0—The Human Metabolome Database in 2013 , 2012, Nucleic Acids Res..

[20]  Alan R. Dabney,et al.  Normalization and missing value imputation for label-free LC-MS analysis , 2012, BMC Bioinformatics.

[21]  Robert W. Williams,et al.  Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits , 2012, Cell.

[22]  R. Levine,et al.  Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-γ2. , 2012, Experimental cell research.

[23]  John Chilton,et al.  Using iRT, a normalized retention time for more targeted measurement of peptides , 2012, Proteomics.

[24]  Evan G. Williams,et al.  NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function , 2011, Cell.

[25]  Nicola Zamboni,et al.  High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. , 2011, Analytical chemistry.

[26]  B. Bonnet,et al.  Multiresidue analysis of multiclass pesticides in lavandin essential oil by LC/MS/MS using the scheduled selected reaction monitoring mode. , 2011, Analytical chemistry.

[27]  Brian J. Bennett,et al.  Comparative Analysis of Proteome and Transcriptome Variation in Mouse , 2011, PLoS genetics.

[28]  M. Selbach,et al.  Global quantification of mammalian gene expression control , 2011, Nature.

[29]  Michele Magrane,et al.  UniProt Knowledgebase: a hub of integrated protein data , 2011, Database J. Biol. Databases Curation.

[30]  A. Dillin,et al.  The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity , 2011, Cell.

[31]  Eleazar Eskin,et al.  A high-resolution association mapping panel for the dissection of complex traits in mice. , 2010, Genome research.

[32]  Benjamin P. Bowen,et al.  Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes , 2009, Diabetes.

[33]  K. Skvorak Animal models of maple syrup urine disease , 2009, Journal of Inherited Metabolic Disease.

[34]  R. Aebersold,et al.  Selected reaction monitoring for quantitative proteomics: a tutorial , 2008, Molecular systems biology.

[35]  Carl W. Cotman,et al.  Gene expression changes in the course of normal brain aging are sexually dimorphic , 2008, Proceedings of the National Academy of Sciences.

[36]  Nichole L. King,et al.  Targeted Quantitative Analysis of Streptococcus pyogenes Virulence Factors by Multiple Reaction Monitoring*S , 2008, Molecular & Cellular Proteomics.

[37]  Daniel Ramot,et al.  The Parallel Worm Tracker: A Platform for Measuring Average Speed and Drug-Induced Paralysis in Nematodes , 2008, PloS one.

[38]  John D. Storey,et al.  Mapping the Genetic Architecture of Gene Expression in Human Liver , 2008, PLoS biology.

[39]  Henry H. N. Lam,et al.  PeptideAtlas: a resource for target selection for emerging targeted proteomics workflows , 2008, EMBO reports.

[40]  R. Muniyappa,et al.  Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats. , 2008, American journal of physiology. Endocrinology and metabolism.

[41]  David R Goodlett,et al.  Genetic basis of proteome variation in yeast , 2007, Nature Genetics.

[42]  Cole M. Haynes,et al.  Ubiquitin-Like Protein 5 Positively Regulates Chaperone Gene Expression in the Mitochondrial Unfolded Protein Response , 2006, Genetics.

[43]  Xiaohui S. Xie,et al.  A Mammalian Organelle Map by Protein Correlation Profiling , 2006, Cell.

[44]  Stephen J. Callister,et al.  Normalization approaches for removing systematic biases associated with mass spectrometry and label-free proteomics. , 2006, Journal of proteome research.

[45]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[46]  E. Schadt,et al.  Genetic inheritance of gene expression in human cell lines. , 2004, American journal of human genetics.

[47]  F. Urano,et al.  Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones , 2004, Journal of Cell Science.

[48]  Yuan-Tsong Chen,et al.  ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. , 2004, The Journal of clinical investigation.

[49]  W. M. Elliott,et al.  A Lung Tissue Bank for Gene Expression Studies in Chronic Obstructive Pulmonary Disease , 2004, COPD.

[50]  Rachel B. Brem,et al.  Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors , 2003, Nature Genetics.

[51]  T. Mackay,et al.  Dopa decarboxylase (Ddc) affects variation in Drosophila longevity , 2003, Nature Genetics.

[52]  Rafael A Irizarry,et al.  Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.

[53]  M. Ryan,et al.  A mitochondrial specific stress response in mammalian cells , 2002, The EMBO journal.

[54]  Yaniv Ziv,et al.  Revealing modular organization in the yeast transcriptional network , 2002, Nature Genetics.

[55]  P. Zipperlen,et al.  Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans , 2000, Genome Biology.

[56]  S. Gygi,et al.  Correlation between Protein and mRNA Abundance in Yeast , 1999, Molecular and Cellular Biology.

[57]  Johan Auwerx,et al.  A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity , 1998, Nature Genetics.

[58]  P. Harper,et al.  Maple syrup urine disease (branched chain ketoaciduria). , 1990, The American journal of pathology.

[59]  M. Haymond,et al.  Glucose and alanine metabolism in children with maple syrup urine disease. , 1978, The Journal of clinical investigation.

[60]  H. Rüdiger,et al.  Maple syrup urine disease variant: Report on an infant , 1974, Zeitschrift für Kinderheilkunde.

[61]  Vincent Mooser,et al.  The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome , 2008, BMC cardiovascular disorders.

[62]  Brian J. Bennett,et al.  Genetic regulation of mouse liver metabolite levels , 2014 .

[63]  R. Aebersold,et al.  Targeted proteomics reveals strain-specific changes in the mouse insulin and central metabolic pathways after a sustained high-fat diet. , 2013, Molecular systems biology.

[64]  Ruedi Aebersold,et al.  High-throughput generation of selected reaction-monitoring assays for proteins and proteomes , 2010, Nature Methods.

[65]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[66]  R. Muniyappa,et al.  Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[67]  Daniel B. Martin,et al.  Computational prediction of proteotypic peptides for quantitative proteomics , 2007, Nature Biotechnology.

[68]  Robert W. Williams,et al.  WebQTL - Web-based complex trait analysis , 2003, Neuroinformatics.

[69]  Brendan MacLean,et al.  Skyline: an open source document editor for creating and analyzing targeted proteomics experiments , 2010, Bioinform..