Bioinspiration from Marine Scaffolds
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Ronald J. Quinn | John W. Blunt | Stephan Böttcher | Angela Di Capua | R. Quinn | J. Blunt | Stephan Böttcher | A. D. Capua | Angela Di Capua
[1] Paola Gramatica,et al. Principles of QSAR models validation: internal and external , 2007 .
[2] Sorel Muresan,et al. Developing a drug-like natural product library. , 2008, Journal of natural products.
[3] D. Newman,et al. Drugs and Drug Candidates from Marine Sources: An Assessment of the Current “State of Play” , 2016, Planta Medica.
[4] Y. Pommier,et al. Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[5] T. Molinski,et al. Drug development from marine natural products , 2009, Nature Reviews Drug Discovery.
[6] Miljanich Gp,et al. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. , 2004 .
[7] Ronald J. Quinn,et al. Scaffold Flatness: Reversing the Trend , 2013, Springer Science Reviews.
[8] Hanna Geppert,et al. Current Trends in Ligand-Based Virtual Screening: Molecular Representations, Data Mining Methods, New Application Areas, and Performance Evaluation , 2010, J. Chem. Inf. Model..
[9] A. Schuffenhauer,et al. Charting biologically relevant chemical space: a structural classification of natural products (SCONP). , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[10] A. L. Risinger,et al. Eribulin Mesylate: Mechanism of Action of a Unique Microtubule-Targeting Agent , 2015, Clinical Cancer Research.
[11] Anang A Shelat,et al. Scaffold composition and biological relevance of screening libraries. , 2007, Nature chemical biology.
[12] Peter Ertl,et al. The scaffold tree: an efficient navigation in the scaffold universe. , 2011, Methods in molecular biology.
[13] Jun Xu,et al. Exploring the Chemodiversity and Biological Activities of the Secondary Metabolites from the Marine Fungus Neosartorya pseudofischeri , 2014, Marine drugs.
[14] Burkhard Haefner,et al. Drugs from the deep: marine natural products as drug candidates. , 2003, Drug discovery today.
[15] Q. Xiao,et al. Absolute configurations of new limonoids from a Krishna mangrove, Xylocarpus granatum. , 2014, Fitoterapia.
[16] Andreas Hofmann,et al. Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs. , 2011, Natural product reports.
[17] Stefan Wetzel,et al. Interactive exploration of chemical space with Scaffold Hunter. , 2009, Nature chemical biology.
[18] Bruno Bienfait. Applications of High-Resolution Self-Organizing Maps to Retrosynthetic and QSAR Analysis , 1994, J. Chem. Inf. Comput. Sci..
[19] J. Reymond. The chemical space project. , 2015, Accounts of chemical research.
[20] Sanjay Joshua Swamidass,et al. Scaffold network generator: a tool for mining molecular structures , 2013, Bioinform..
[21] A. Hopkins,et al. Navigating chemical space for biology and medicine , 2004, Nature.
[22] Herbert Waldmann,et al. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. , 2002, Angewandte Chemie.
[23] Andrés Francesch,et al. Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem. , 2009, Natural product reports.
[24] Lei Chen,et al. Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicines , 2013, Journal of Cheminformatics.
[25] J. Reymond,et al. Exploring chemical space for drug discovery using the chemical universe database. , 2012, ACS chemical neuroscience.
[26] H. Luesch,et al. Marine natural products: a new wave of drugs? , 2011, Future medicinal chemistry.
[27] Tingjun Hou,et al. Drug and Drug Candidate Building Block Analysis , 2010, J. Chem. Inf. Model..
[28] Clemencia Pinilla,et al. A Similarity‐based Data‐fusion Approach to the Visual Characterization and Comparison of Compound Databases , 2007, Chemical biology & drug design.
[29] Howard S. Smith,et al. Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain , 2009, Therapeutics and clinical risk management.
[30] Herbert Waldmann,et al. From protein domains to drug candidates – natural products as guiding principles in , 2002 .
[31] Stefan Wetzel,et al. The Scaffold Tree - Visualization of the Scaffold Universe by Hierarchical Scaffold Classification , 2007, J. Chem. Inf. Model..
[32] G. Bemis,et al. The properties of known drugs. 1. Molecular frameworks. , 1996, Journal of medicinal chemistry.
[33] Tudor I. Oprea,et al. Chemography: the Art of Navigating in Chemical Space , 2000 .
[34] Jérôme Hert,et al. Quantifying Biogenic Bias in Screening Libraries , 2009, Nature chemical biology.
[35] Sanjay Joshua Swamidass,et al. Utility-Aware Screening with Clique-Oriented Prioritization , 2012, J. Chem. Inf. Model..
[36] W. Guida,et al. The art and practice of structure‐based drug design: A molecular modeling perspective , 1996, Medicinal research reviews.
[37] Xiao‐Ming Li,et al. Varioxepine A, a 3H-oxepine-containing alkaloid with a new oxa-cage from the marine algal-derived endophytic fungus Paecilomyces variotii. , 2014, Organic letters.
[38] C. Humblet,et al. Escape from flatland: increasing saturation as an approach to improving clinical success. , 2009, Journal of medicinal chemistry.
[39] C. Dobson. Chemical space and biology , 2004, Nature.
[40] Nils M. Kriege,et al. Visual Analysis of Biological Activity Data with Scaffold Hunter , 2013, Molecular informatics.
[41] H. Gaspar,et al. Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success , 2014, Marine drugs.
[42] Craig J. Forsyth,et al. Total synthesis of halichondrin B and norhalichondrin B , 1992 .
[43] B. Petrovska,et al. Historical review of medicinal plants’ usage , 2012, Pharmacognosy reviews.
[44] Sarah R. Langdon,et al. Scaffold Diversity of Exemplified Medicinal Chemistry Space , 2011, J. Chem. Inf. Model..
[45] D. Faulkner,et al. Marine natural products. , 2000, Natural product reports.
[46] C. García-echeverría,et al. Antibody-drug conjugates—a new wave of cancer drugs. , 2014, Bioorganic & medicinal chemistry letters.
[47] Herbert Waldmann,et al. Charting Biological and Chemical Space: PSSC and SCONP as Guiding Principles for the Development of Compound Collections Based on Natural Product Scaffolds , 2006 .
[48] Ronald J. Quinn,et al. Capturing Nature's Diversity , 2015, PloS one.
[49] Lorenz C. Blum,et al. Classification of Organic Molecules by Molecular Quantum Numbers , 2009, ChemMedChem.
[50] A. Ganesan. The impact of natural products upon modern drug discovery. , 2008, Current opinion in chemical biology.
[51] Peter Ertl,et al. Mining for Bioactive Scaffolds with Scaffold Networks: Improved Compound Set Enrichment from Primary Screening Data , 2011, J. Chem. Inf. Model..
[52] Stefan Wetzel,et al. Natural-product-derived fragments for fragment-based ligand discovery , 2012, Nature Chemistry.
[53] David Rogers,et al. Extended-Connectivity Fingerprints , 2010, J. Chem. Inf. Model..
[54] Matthew R Trendowski. Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products , 2015, Drugs.
[55] Tudor I. Oprea,et al. Novel chemical space exploration via natural products. , 2009, Journal of medicinal chemistry.