Genetic polymorphisms of adiponectin and tumor necrosis factor‐alpha and nonalcoholic fatty liver disease in Chinese people

Background and Aim:  Hypoadiponectinemia and high tumor necrosis factor‐alpha (TNF‐α) levels are associated with the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the genetic polymorphisms of adiponectin and TNF‐α in Chinese NAFLD patients and their association with disease severity.

[1]  P. O S I T I O N S T A T E M E N T,et al.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[2]  Jun Yu,et al.  Association of cytokine gene polymorphisms and liver fibrosis in chronic hepatitis B , 2008, Journal of gastroenterology and hepatology.

[3]  H. J. de Silva,et al.  How should we manage patients with non‐alcoholic fatty liver disease in 2007? , 2007, Journal of gastroenterology and hepatology.

[4]  M. Taniai,et al.  Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis. , 2007, Journal of hepatology.

[5]  F. Chan,et al.  Prevalence of undiagnosed diabetes and postchallenge hyperglycaemia in Chinese patients with non‐alcoholic fatty liver disease , 2006, Alimentary pharmacology & therapeutics.

[6]  V. Wong,et al.  Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[7]  R. Stratta,et al.  Pancreas and islet transplantation in type 1 diabetes. , 2006, Diabetes care.

[8]  F. Kronenberg,et al.  The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians , 2006, European Journal of Human Genetics.

[9]  Z. Canturk,et al.  Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease , 2006, European journal of gastroenterology & hepatology.

[10]  Lisa J. Martin,et al.  Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. , 2006, Diabetes.

[11]  Tetsuji Sato,et al.  The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. , 2006, Annals of internal medicine.

[12]  C. McClain,et al.  Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. , 2005, The Journal of pediatrics.

[13]  I. Leclercq,et al.  NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. , 2005, Gastroenterology.

[14]  G. Pacini,et al.  Hypoadiponectinemia Predicts the Severity of Hepatic Fibrosis and Pancreatic Beta-Cell Dysfunction in Nondiabetic Nonobese Patients with Nonalcoholic Steatohepatitis , 2005, The American Journal of Gastroenterology.

[15]  O. Uygur-Bayramiçli,et al.  Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients? , 2005, World journal of gastroenterology.

[16]  C. Zou,et al.  Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children. , 2005, Endocrine journal.

[17]  J. H. Lee,et al.  Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans. , 2005, The American journal of clinical nutrition.

[18]  D. Koop,et al.  Steatohepatitis induced by intragastric overfeeding in mice , 2005, Hepatology.

[19]  Paul Zimmet,et al.  The metabolic syndrome—a new worldwide definition , 2005, The Lancet.

[20]  Y. Iwamoto,et al.  Prevalence of non‐alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults , 2005, Diabetic medicine : a journal of the British Diabetic Association.

[21]  S. Sanderson,et al.  The natural history of nonalcoholic fatty liver disease: a population-based cohort study. , 2005, Gastroenterology.

[22]  G. Marchesini,et al.  Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. , 2005, The Journal of clinical endocrinology and metabolism.

[23]  M. Arca,et al.  The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age ≤50 years) , 2005, Journal of Molecular Medicine.

[24]  J. Sung,et al.  Histological progression of non‐alcoholic fatty liver disease in Chinese patients , 2005, Alimentary pharmacology & therapeutics.

[25]  L. Sechi,et al.  Plasma adiponectin is decreased in nonalcoholic fatty liver disease. , 2005, European journal of endocrinology.

[26]  Jonathan C. Cohen,et al.  Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity , 2004, Hepatology.

[27]  K. Lindor,et al.  A Pilot Trial of Pentoxifylline in Nonalcoholic Steatohepatitis , 2004, The American Journal of Gastroenterology.

[28]  H. Tilg,et al.  Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. , 2004, Biochemical and biophysical research communications.

[29]  S. Sarin,et al.  Beneficial Effects of Tumor Necrosis Factor-α Inhibition by Pentoxifylline on Clinical, Biochemical, and Metabolic Parameters of Patients with Nonalcoholic Steatohepatitis , 2004, American Journal of Gastroenterology.

[30]  F. Chan,et al.  Clinical and histological features of non‐alcoholic fatty liver disease in Hong Kong Chinese , 2004, Alimentary pharmacology & therapeutics.

[31]  J. Kench,et al.  Beyond insulin resistance in NASH: TNF‐α or adiponectin? , 2004, Hepatology.

[32]  P. Hayashi,et al.  The natural history of nonalcoholic fatty liver disease: a clinical histopathological study , 2003, American Journal of Gastroenterology.

[33]  G. Marchesini,et al.  Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome , 2003, Hepatology.

[34]  A. Moser,et al.  Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease , 2003, Hepatology.

[35]  P. Scherer,et al.  A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. , 2002, Diabetes.

[36]  L. N. Valenti,et al.  Tumor necrosis factor α promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease , 2002 .

[37]  J. Crespo,et al.  Gene expression of tumor necrosis factor α and TNF‐receptors, p55 and p75, in nonalcoholic steatohepatitis patients , 2001 .

[38]  J. Chan,et al.  Lower BMI cut-off value to define obesity in Hong Kong Chinese: an analysis based on body fat assessment by bioelectrical impedance. , 2001, The British journal of nutrition.

[39]  K. Feingold,et al.  TNF-alpha is not the cause of fatty liver disease in obese diabetic mice. , 2001, Nature medicine.

[40]  M. Carrington,et al.  Interleukin-1 polymorphisms associated with increased risk of gastric cancer , 2000, Nature.

[41]  G. Brandi,et al.  Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy , 2000, Annals of Internal Medicine.

[42]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions , 1999, American Journal of Gastroenterology.

[43]  A. Kimura,et al.  Polymorphism of the 5′‐flanking region of the human tumor necrosis factor (TNF)‐α gene in Japanese , 1998 .

[44]  A. Kimura,et al.  Polymorphism of the 5'-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese. , 1998, Tissue antigens.

[45]  R. Hanson,et al.  The natural history of nonalcoholic steatohepatitis: A follow‐up study of forty‐two patients for up to 21 years , 1990, Hepatology.

[46]  H. Nomura,et al.  Prevalence of fatty liver in a general population of Okinawa, Japan. , 1988, Japanese journal of medicine.

[47]  P. Christoffersen,et al.  Liver histology in a 'normal' population--examinations of 503 consecutive fatal traffic casualties. , 1977, Scandinavian journal of gastroenterology.