Challenges to environmental toxicology and epidemiology: where do we stand and which way do we go?

[1]  Jan G Hengstler,et al.  Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective. , 2004, Toxicology letters.

[2]  Y. Ko,et al.  Polymorphic metabolic susceptibility genes and longevity: a study in octogonarians. , 2004, Toxicology letters.

[3]  Holger Schwender,et al.  A pilot study on the application of statistical classification procedures to molecular epidemiological data. , 2004, Toxicology letters.

[4]  M. Dosemeci,et al.  Pooled exposure–response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study , 2001, Cancer Causes & Control.

[5]  H M Bolt,et al.  Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. , 2003, Annual review of pharmacology and toxicology.

[6]  Valerie Beral,et al.  Breast cancer and hormone-replacement therapy in the Million Women Study , 2003, The Lancet.

[7]  H. Bolt.  Genotoxicity--threshold or not? Introduction of cases of industrial chemicals. , 2003, Toxicology letters.

[8]  Ricarda Thier,et al.  The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine , 2003, International archives of occupational and environmental health.

[9]  T. Brüning,et al.  Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. , 2003, International journal of hygiene and environmental health.

[10]  Igor Burstyn,et al.  Studies of carcinogenicity of bitumen fume in humans. , 2003, American journal of industrial medicine.

[11]  Fengzhu Sun,et al.  Haplotype block structure and its applications to association studies: power and study designs. , 2002, American journal of human genetics.

[12]  J. Wakefield.  Environmental genome project: focusing on differences to understand the whole. , 2002, Environmental health perspectives.

[13]  N. Caporaso.  Why have we failed to find the low penetrance genetic constituents of common cancers? , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[14]  J. Beckmann,et al.  A highly significant association between a COMT haplotype and schizophrenia. , 2002, American journal of human genetics.

[15]  David E Stikkers.  Octane and the environment. , 2002, The Science of the total environment.

[16]  K Steenland,et al.  Exposure-response analysis and risk assessment for silica and silicosis mortality in a pooled analysis of six cohorts , 2002, Occupational and environmental medicine.

[17]  Michal Abrahamowicz,et al.  Modeling smoking history: a comparison of different approaches. , 2002, American journal of epidemiology.

[18]  L. Marchand,et al.  Erratum: Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk (Carcinogenesis (2002) vol. 23 (1343-1350)) , 2002 .

[19]  G. Sciarra,et al.  Validity of empirical models of exposure in asphalt paving , 2002, Occupational and environmental medicine.

[20]  M. Adams,et al.  Recent Segmental Duplications in the Human Genome , 2002, Science.

[21]  L. Le Marchand,et al.  Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. , 2002, Carcinogenesis.

[22]  Esteban Ballestar,et al.  The impact of chromatin in human cancer: linking DNA methylation to gene silencing. , 2002, Carcinogenesis.

[23]  E. Calabrese,et al.  Applications of hormesis in toxicology, risk assessment and chemotherapeutics. , 2002, Trends in pharmacological sciences.

[24]  F. Gannon,et al.  Human estrogen receptor-α: regulation by synthesis, modification and degradation , 2002, Cellular and Molecular Life Sciences CMLS.

[25]  Jan Vijg,et al.  Large genome rearrangements as a primary cause of aging , 2002, Mechanisms of Ageing and Development.

[26]  Mel Greaves,et al.  Cancer causation: the Darwinian downside of past success? , 2002, The Lancet. Oncology.

[27]  David J Porteous,et al.  Computational comparison of human genomic sequence assemblies for a region of chromosome 4. , 2002, Genome research.

[28]  J. Hirschhorn,et al.  A comprehensive review of genetic association studies , 2002, Genetics in Medicine.

[29]  H. Bolt.  Occupational versus environmental and lifestyle exposures of children and adolescents in the European Union. , 2002, Toxicology letters.

[30]  T. Brüning,et al.  Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts. , 2002, Toxicology letters.

[31]  P. Chapman.  Defining hormesis: comments on Calabrese and Baldwin (2002) , 2002, Human & experimental toxicology.

[32]  K. Kitchin.  Defining, explaining and understanding hormesis , 2002, Human & experimental toxicology.

[33]  A. Ducrest,et al.  Regulation of the human telomerase reverse transcriptase gene , 2002, Oncogene.

[34]  J. Herman,et al.  Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours , 2002, The Journal of pathology.

[35]  Stuart Schwartz,et al.  Human-specific duplication and mosaic transcripts: the recent paralogous structure of chromosome 22. , 2002, American journal of human genetics.

[36]  R. Watson,et al.  Altered DNA methylation: a secondary mechanism involved in carcinogenesis. , 2002, Annual review of pharmacology and toxicology.

[37]  S. Garte,et al.  Metabolic susceptibility genes as cancer risk factors: time for a reassessment? , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[38]  L. Palmer,et al.  Genomewide scans of complex human diseases: true linkage is hard to find. , 2001, American journal of human genetics.

[39]  H. Bolt,et al.  The new era of toxicology. , 2001, Trends in pharmacological sciences.

[40]  Jacques Ferlay,et al.  Estimating the world cancer burden: Globocan 2000 , 2001, International journal of cancer.

[41]  W. Xiong,et al.  Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites. , 2001, Nucleic acids research.

[42]  Julio Benítez,et al.  Functionally Active Duplications of the CYP2D6 Gene Are More Prevalent among Larynx and Lung Cancer Patients , 2001, Oncology.

[43]  M. Ernst,et al.  Behavioral and neural consequences of prenatal exposure to nicotine. , 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

[44]  T. Brüning,et al.  Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. , 2001, Cancer research.

[45]  I. Thompson,et al.  A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. , 2001, Nucleic acids research.

[46]  G. Cammarata,et al.  Conserved structure and promoter sequence similarity in the mouse and human genes encoding the zinc finger factor BERF-1/BFCOL1/ZBP-89. , 2001, Biochemical and biophysical research communications.

[47]  W. Ahrens,et al.  Lung cancer and cigarette smoking in Europe: An update of risk estimates and an assessment of inter‐country heterogeneity , 2001, International journal of cancer.

[48]  D. Haussler,et al.  A physical map of the human genome , 2001, Nature.

[49]  E. Taioli,et al.  International collaborative study on genetic susceptibility to environmental carcinogens (GSEC): an update. , 2001, International journal of hygiene and environmental health.

[50]  A. Michnea,et al.  Impact of metals on the environment due to technical accident at Aurul Baia Mare, Romania. , 2001, International journal of occupational medicine and environmental health.

[51]  R. Houlston.  CYP1A1 polymorphisms and lung cancer risk: a meta-analysis. , 2000, Pharmacogenetics.

[52]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[53]  C Béroud,et al.  p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis , 2000, Human mutation.

[54]  T. Brüning,et al.  Renal Toxicity and Carcinogenicity of Trichloroethylene: Key Results, Mechanisms, and Controversies , 2000, Critical reviews in toxicology.

[55]  P. Hanawalt,et al.  A phylogenomic study of DNA repair genes, proteins, and processes. , 1999, Mutation research.

[56]  M. Ingelman-Sundberg,et al.  Duplication, multiduplication, and amplification of genes encoding drug-metabolizing enzymes: evolutionary, toxicological, and clinical pharmacological aspects. , 1999, Drug metabolism reviews.

[57]  J. Brosius,et al.  RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements. , 1999, Gene.

[58]  C. Schmidt.  Answering the endocrine test questions. , 1999, Environmental health perspectives.

[59]  E. Taioli.  International collaborative study on genetic susceptibility to environmental carcinogens. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[60]  A R Feinstein,et al.  Clinical epidemiological quality in molecular genetic research: the need for methodological standards. , 1999, JAMA.

[61]  A EisenJ,et al.  DNA修復遺伝子,タンパクと過程のphylogenomic(系統発生的ゲノム)調査 , 1999 .

[62]  Jürgen Brosius,et al.  Genomes were forged by massive bombardments with retroelements and retrosequences. , 1999 .

[63]  F. Guengerich.  The Environmental Genome Project: functional analysis of polymorphisms. , 1998, Environmental health perspectives.

[64]  J M Robins,et al.  Differential misclassification and the assessment of gene-environment interactions in case-control studies. , 1998, American journal of epidemiology.

[65]  L. Hayflick.  Mortality and immortality at the cellular level. A review. , 1997, Biochemistry. Biokhimiia.

[66]  F. Campbell,et al.  Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration. , 1997, Carcinogenesis.

[67]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[68]  N. Vermeulen,et al.  Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway. , 1995, Chemical research in toxicology.

[69]  A. Bird,et al.  DNA methylation and chromatin structure , 1991, FEBS letters.

[70]  W. Dekant,et al.  Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation. , 1990, Chemico-biological interactions.

[71]  A. Weiner,et al.  Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information. , 1986, Annual review of biochemistry.

[72]  F P Perera,et al.  Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. , 1982, Journal of chronic diseases.

[73]  R. Doll,et al.  The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. , 1981, Journal of the National Cancer Institute.