Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram.
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S. King | D. Barnes | S. Wittenberger | S. Wagaw | Seble H Wagaw | Michael G Fickes | David M Barnes | Jianguo Ji | Michael A Fitzgerald | Steven A King | Howard E Morton | Frederick A Plagge | Margo Preskill | Steven J Wittenberger | Ji Zhang | Ji Zhang | J. Ji | H. Morton | M. Fickes | Michael A. Fitzgerald | F. Plagge | Margo Preskill