Epilepsy and sudden unexpected death in epilepsy?: eat more fish! A group hypothesis.

Epilepsy is the commonest serious neurological disorder and individuals with epilepsy are at higher risk of death than the general population and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures play a potential role. The ultimate goal of SUDEP research is to develop methods to prevent it and nutritional aspects such as omega-3 fatty acid deficiency may have an interesting role in this scenario. Omega-3 fatty acids reduce the risk of cardiovascular mortality and are important for treating or preventing some neurological diseases, including epilepsy. A dietary modification or nutritional supplements increasing the ingestion of omega-3 fatty acids may help to ''save the brain'.

[1]  J. Cereghino The major advances in epilepsy in the 20th century and what we can expect (hope for) in the future , 2009, Epilepsia.

[2]  C. DeGiorgio,et al.  n-3 fatty acids (eicosapentanoic and docosahexanoic acids) in epilepsy and for the prevention of sudden unexpected death in epilepsy , 2008, Epilepsy & Behavior.

[3]  Philippe Ryvlin,et al.  Sudden unexpected death in epilepsy: current knowledge and future directions , 2008, The Lancet Neurology.

[4]  F. Scorza,et al.  The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy , 2008, Epilepsy & Behavior.

[5]  J. Bourre,et al.  Seafood (wild and farmed) for the elderly: Contribution to the dietary intakes of iodine, selenium, DHA and vitamins B12 and D , 2008, The journal of nutrition, health & aging.

[6]  K. Jeejeebhoy Benefits and risks of a fish diet—should we be eating more or less? , 2008, Nature Clinical Practice Gastroenterology &Hepatology.

[7]  G. Cole,et al.  Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.

[8]  J. Domingo Omega-3 fatty acids and the benefits of fish consumption: is all that glitters gold? , 2007, Environment international.

[9]  K. Ohara The n-3 polyunsaturated fatty acid/dopamine hypothesis of schizophrenia , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[10]  Salvatore Mazza,et al.  Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  N. Sahyoun,et al.  Fish consumption: recommendations versus advisories, can they be reconciled? , 2005, Nutrition reviews.

[12]  Josemir W Sander,et al.  Is omega-3 fatty acid deficiency a factor contributing to refractory seizures and SUDEP? A hypothesis , 2004, Seizure.

[13]  U. Das Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how? , 2000, Prostaglandins, leukotrienes, and essential fatty acids.

[14]  G. Billman,et al.  The Antiarrhythmic and Anticonvulsant Effects of Dietary N-3 Fatty Acids , 1999, The Journal of Membrane Biology.

[15]  Fish: friend or foe? In addition to heart-healthy omega-3 fats, seafood can carry mercury and other toxins. For most people, the benefits of eating fish far outweigh the risks. , 2007, Harvard heart letter : from Harvard Medical School.

[16]  A. Leaf The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n−3 polyunsaturated fatty acids: Heart and brain , 2001, Lipids.