An Outbreak of Extended-Spectrum β-Lactamase–Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit

We present a large outbreak of ESBL-producing Klebsiella pneumoniae in a neonatal intensive care unit that resulted in 31 colonized infants, 10 invasive infections, and 5 attributable deaths over a 5-month period. Although the source of infection was unknown, overcrowding and understaffing appeared to have been aggravating factors.

[1]  D. Pakstis,et al.  Risk factors and outcome of extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections. , 2011, International journal of antimicrobial agents.

[2]  K. Bush.  Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. , 2010, Current opinion in microbiology.

[3]  F. Gudiol,et al.  Bacteraemia due to extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) in cancer patients: clinical features, risk factors, molecular epidemiology and outcome. , 2010, The Journal of antimicrobial chemotherapy.

[4]  F. Baquero,et al.  In vitro susceptibilities of aerobic and facultatively anaerobic gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2005 results from Study for Monitoring Antimicrobial Resistance Trends (SMART). , 2009, Surgical infections.

[5]  H. Rüden,et al.  Outbreaks in neonatal intensive care units - they are not like others. , 2007, American journal of infection control.

[6]  F. Baquero,et al.  In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends). , 2006, The Journal of antimicrobial chemotherapy.

[7]  Victor L. Yu,et al.  Outcome of Cephalosporin Treatment for Serious Infections Due to Apparently Susceptible Organisms Producing Extended-Spectrum β-Lactamases: Implications for the Clinical Microbiology Laboratory , 2001, Journal of Clinical Microbiology.

[8]  D. Pittet,et al.  Outbreak of Enterobacter cloacae Related to Understaffing, Overcrowding, and Poor Hygiene Practices , 1999, Infection Control & Hospital Epidemiology.

[9]  V. Rotimi,et al.  The development of the bacterial flora in normal neonates. , 1981, Journal of medical microbiology.