论文信息 - COMPLEMENTing the diagnosis of aHUS.

COMPLEMENTing the diagnosis of aHUS.

In this issue of Blood , Noris et al describe a functional complement assay that can be used to diagnose atypical hemolytic-uremic syndrome (aHUS).[1][1] This assay might also be useful in identifying aHUS patients in remission and in detecting asymptomatic carriers of complement gene mutations.

V. Afshar-Kharghan

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[2] John Hwa,et al. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome , 2013, Nature Genetics.

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[4] P. Zipfel,et al. Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. , 2008, Blood.

[5] J. Goodship,et al. Genetic studies into inherited and sporadic hemolytic uremic syndrome. , 1998, Kidney international.

[6] R. Thompson,et al. Hypocomplementaemia due to a genetic deficiency of beta 1H globulin. , 1981, Clinical and experimental immunology.