Rapid plugged flow synthesis of nucleoside analogues via Suzuki-Miyaura coupling and heck Alkenylation of 5-Iodo-2’-deoxyuridine (or cytidine)
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S. Hilton | J. Serrano | A. Kapdi | R. Dandela | Y. Sanghvi | Santosh Kori | Sujeet Gaware | Sujeet A. Gaware
[1] L. Degennaro,et al. Unlocking geminal fluorohaloalkanes in nucleophilic fluoroalkylation chemistry: generation and trapping of lithiumfluorocarbenoids enabled by flow microreactors. , 2023, Chemical communications.
[2] A. Kapdi,et al. PTABS: A Unique Water-Soluble π-Acceptor Caged Phosphine , 2022, Synlett.
[3] A. Kapdi,et al. Room Temperature Dialkylamination of ChloroHeteroarenes Using Cu(II)/PTABS Catalytic System. , 2022, Chemistry, an Asian journal.
[4] T. Noël,et al. Membrane-based TBADT recovery as a strategy to increase the sustainability of continuous-flow photocatalytic HAT transformations , 2022, Nature Communications.
[5] K. H. Shaughnessy. Covalent Modification of Nucleobases using Water‐Soluble Palladium Catalysts , 2022, Chemical record.
[6] J. Serrano,et al. Suzuki‐Miyaura Coupling, Heck Alkenylation, and Amidation of DMTr‐Protected 5‐Iodo‐2′‐Deoxyuridine via Palladium‐catalyzed Reactions , 2022, Current protocols.
[7] G. D. Di Liberto,et al. Interfacing single-atom catalysis with continuous-flow organic electrosynthesis. , 2022, Chemical Society reviews.
[8] J. Cossy,et al. Ni-catalyzed Cross-coupling of 2-Iodoglycals and 2-Iodoribals with Grignard Reagents: A Route to 2-C-Glycosides and 2-C-Nucleosides. , 2022, Chemistry.
[9] Ana I. Benítez-Mateos,et al. Sustainable Flow‐Synthesis of (Bulky) Nucleoside Drugs by a Novel and Highly Stable Nucleoside Phosphorylase Immobilized on Reusable Supports , 2021, ChemSusChem.
[10] M. Baumann,et al. Continuous Flow Synthesis of Anticancer Drugs , 2021, Molecules.
[11] M. Smietana,et al. Direct Access to Unique C‐5’‐acyl Modified Nucleosides through Liebeskind‐Srogl Cross Coupling Reaction , 2021, European Journal of Organic Chemistry.
[12] T. Noël,et al. Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry , 2021, Chemical reviews.
[13] T. Noël,et al. Rapid and Direct Photocatalytic C(sp3)−H Acylation and Arylation in Flow , 2021, Angewandte Chemie.
[14] T. Diao,et al. Synthesis of C-acyl furanosides via the cross-coupling of glycosyl esters with carboxylic acids , 2021, Chemical science.
[15] D. K. Maity,et al. Room-Temperature Amination of Chloroheteroarenes in Water by a Recyclable Copper(II)-Phosphaadamantanium Sulfonate System. , 2021, The Journal of organic chemistry.
[16] P. Watts,et al. Multistep Continuous Flow Synthesis of Stavudine. , 2021, The Journal of organic chemistry.
[17] I. Baxendale,et al. A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries , 2021, Beilstein journal of organic chemistry.
[18] S. Ley,et al. A Comment on Continuous Flow Technologies within the Agrochemical Industry , 2021 .
[19] Klavs F. Jensen,et al. Ready, Set, Flow! Automated Continuous Synthesis and Optimization , 2021 .
[20] C. Schulzke,et al. 1,3,5‐Triaza‐7‐phosphaadamantane (PTA) Derived Caged Phosphines for Palladium‐Catalyzed Selective Functionalization of Nucleosides and Heteroarenes , 2020, Chemical record.
[21] Luis F. García,et al. Imine-Palladacycles as Phosphine-Free Precatalysts for Low-Temperature Suzuki–Miyaura Synthesis of Nucleoside Analogues in Aqueous Media , 2020 .
[22] P. Seeberger,et al. How to approach flow chemistry. , 2020, Chemical Society reviews.
[23] A. Kapdi,et al. Scale-Up of a Heck Alkenylation Reaction: Application to the Synthesis of an Amino-Modifier Nucleoside ‘Ruth Linker’ , 2020, Synthesis.
[24] Jason D. Williams,et al. Oscillatory flow reactors for synthetic chemistry applications , 2020, Journal of Flow Chemistry.
[25] C. Kappe,et al. The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow , 2020, Accounts of chemical research.
[26] D. Bergbreiter,et al. Minimizing solvent waste in catalytic reactions in highly recyclable hydrocarbon solvents. , 2020, Organic & biomolecular chemistry.
[27] G. Romanazzi,et al. Flow Microreactor Technology for Taming Highly Reactive Chloroiodomethyllithium Carbenoid: Direct and Chemoselective Synthesis of α-Chloroaldehydes. , 2020, Organic letters.
[28] A. Kapdi,et al. Discovery, Synthesis, and Scale-up of Efficient Palladium Catalysts Useful for the Modification of Nucleosides and Heteroarenes , 2020, Molecules.
[29] I. Parkin,et al. Highly reproducible, high-yield flow synthesis of gold nanoparticles based on a rational reactor design exploiting the reduction of passivated Au(iii) , 2020, Reaction Chemistry & Engineering.
[30] R. Luisi,et al. Flow Technology for Genesis and Use of (Highly) Reactive Organometallic Reagents. , 2020, Chemistry.
[31] S. Ley,et al. A practical method for continuous production of sp3-rich compounds from (hetero)aryl halides and redox-active esters. , 2020, Chemistry.
[32] T. Noël,et al. The Fundamentals Behind the Use of Flow Reactors in Electrochemistry , 2019, Accounts of chemical research.
[33] B. Bhanage,et al. Pd/PTABS: An Efficient Catalytic System for the Aminocarbonylation of a Sugar-Protected Nucleoside , 2019, Synthesis.
[34] S. Hilton,et al. Supporting‐Electrolyte‐Free Electrochemical Methoxymethylation of Alcohols Using a 3D‐Printed Electrosynthesis Continuous Flow Cell System , 2019, ChemElectroChem.
[35] A. Pruijssers,et al. Nucleoside analogues for the treatment of coronavirus infections , 2019, Current Opinion in Virology.
[36] S. Hilton,et al. Modular 3D Printed Compressed Air Driven Continuous-Flow Systems for Chemical Synthesis , 2019, European Journal of Organic Chemistry.
[37] C. Schulzke,et al. Pd/PTABS: Low Temperature Etherification of Chloroheteroarenes. , 2018, The Journal of organic chemistry.
[38] C. Schulzke,et al. Pd/PTABS: An Efficient Water‐Soluble Catalytic System for the Amination of 6‐Chloropurine Ribonucleoside and Synthesis of Alogliptin , 2018, Current protocols in nucleic acid chemistry.
[39] Y. Ni,et al. Cytidine-stabilized copper nanoclusters as a fluorescent probe for sensing of copper ions and hemin , 2018, RSC advances.
[40] Fang-fang Lai,et al. A Suzuki-Miyaura method for labelling proliferating cells containing incorporated BrdU. , 2018, The Analyst.
[41] Ivan Trentin,et al. Pd/PTABS: Catalyst for Room Temperature Amination of Heteroarenes. , 2018, Organic letters.
[42] M. Ladlow,et al. 3D‐Printed Polypropylene Continuous‐Flow Column Reactors: Exploration of Reactor Utility in SNAr Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles , 2017 .
[43] P. Seeberger,et al. The Hitchhiker's Guide to Flow Chemistry ∥. , 2017, Chemical reviews.
[44] D. Lilley,et al. Fluorescent RNA cytosine analogue – an internal probe for detailed structure and dynamics investigations , 2017, Scientific Reports.
[45] Paul Watts,et al. Semi-continuous multi-step synthesis of lamivudine. , 2017, Organic & biomolecular chemistry.
[46] S. Koenig,et al. Recent advances in flow chemistry in the pharmaceutical industry , 2017 .
[47] C. Kappe,et al. Halogenation of organic compounds using continuous flow and microreactor technology , 2017 .
[48] C. Schulzke,et al. Novel water-soluble phosphatriazenes: versatile ligands for Suzuki–Miyaura, Sonogashira and Heck reactions of nucleosides , 2016 .
[49] C. Schulzke,et al. C‐C Bond Formation: Synthesis of C5 Substituted Pyrimidine and C8 Substituted Purine Nucleosides Using Water Soluble Pd‐imidate Complex , 2016, Current protocols in nucleic acid chemistry.
[50] C. Schulzke,et al. Water-Soluble Pd-Imidate Complexes: Broadly Applicable Catalysts for the Synthesis of Chemically Modified Nucleosides via Pd-Catalyzed Cross-Coupling. , 2016, The Journal of organic chemistry.
[51] Shuj Kobayashi,et al. Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods , 2015, Chemistry, an Asian journal.
[52] David Cantillo,et al. Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients. , 2015, Angewandte Chemie.
[53] K. H. Shaughnessy. Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides , 2015, Molecules.
[54] C. Len,et al. Heck and Sonogashira couplings in aqueous media – application to unprotected nucleosides and nucleotides , 2015 .
[55] P. Lozano,et al. Pd–imidate complexes as recyclable catalysts for the synthesis of C5-alkenylated pyrimidine nucleosides via Heck cross-coupling reaction , 2015 .
[56] C. Len,et al. Synthesis of C-Arylnucleoside Analogues , 2015, Molecules.
[57] C. Len,et al. Aqueous microwave-assisted cross-coupling reactions applied to unprotected nucleosides , 2015, Front. Chem..
[58] A. Kapdi,et al. Modulation of the Electronic Properties of Non-innocent (E,E)-Dibenzylideneacetone for Palladium(0)-Mediated Heck Alkenylation of 5-Iodo-2′-deoxyuridine and Scale-Up Studies , 2015, Synthesis.
[59] C. Len,et al. First ligand-free, microwave-assisted, Heck cross-coupling reaction in pure water on a nucleoside – application to the synthesis of antiviral BVDU , 2014 .
[60] J. Serrano,et al. [Pd(C^N)(X)(PPh₃)] palladacycles react with 2,4,6-trifluorophenyl boronic acid to give stable transmetallation products of the type [Pd(C^N)(2,4,6-F₃C₆H₂)(PPh₃)]. , 2014, Chemical communications.
[61] I. da Silva,et al. New water soluble Pd-imidate complexes as highly efficient catalysts for the synthesis of C5-arylated pyrimidine nucleosides , 2014 .
[62] S. Ley,et al. Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin , 2013, ACS omega.
[63] C. Len,et al. Improved Microwave‐Assisted Ligand‐Free Suzuki—Miyaura Cross‐Coupling of 5‐Iodo‐2′‐deoxyuridine in Pure Water. , 2013 .
[64] C. Len,et al. Synthesis of 6-aryluridines via Suzuki–Miyaura cross-coupling reaction at room temperature under aerobic ligand-free conditions in neat water , 2013 .
[65] Christophe Len,et al. Improved microwave-assisted ligand-free Suzuki–Miyaura cross-coupling of 5-iodo-2′-deoxyuridine in pure water , 2013 .
[66] S. Srivatsan,et al. Fluorescent Nucleoside Analogs: Probes for Investigating Nucleic Acid Structure and Function , 2013 .
[67] B. Fischer,et al. Fluorescent p-substituted-phenyl-imidazolo-cytidine analogues , 2013 .
[68] L. Agrofoglio,et al. Efficient Synthesis of Unprotected C-5-Aryl/Heteroaryl-2'-deoxyuridine via a Suzuki-Miyaura Reaction in Aqueous Media , 2012, Molecules.
[69] J. Serrano,et al. Synthesis and Characterization of Imine-Palladacycles Containing Imidate “Pseudohalide” Ligands: Efficient Suzuki–Miyaura Cross-Coupling Precatalysts and Their Activation To Give Pd0Ln Species (L = Phosphine) , 2011 .
[70] I. da Silva,et al. New cyclometallated precursors of unsubstituted N-phenylpyrazole [{Pd(phpz)(μ-X)}2] (X = AcO or OH) and study of their reactivity towards selected ligands. , 2011, Dalton transactions.
[71] C. Oliver Kappe,et al. Continuous flow organic synthesis under high-temperature/pressure conditions. , 2010, Chemistry, an Asian journal.
[72] Kevin H Shaughnessy,et al. Hydrophilic ligands and their application in aqueous-phase metal-catalyzed reactions. , 2009, Chemical reviews.
[73] J. Serrano,et al. Halide and Pseudohalide Effects in Pd‐Catalyzed Cross‐Coupling Reactions , 2007 .
[74] J. Serrano,et al. Halide and pseudohalide effects in Pd-catalysed cross-coupling reactions , 2006 .
[75] J. Serrano,et al. Air‐Stable, Phosphine‐Free Anionic Palladacyclopentadienyl Catalysts: Remarkable Halide and Pseudohalide Effects in Stille Coupling , 2006 .
[76] E. Clercq,et al. Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. , 2004 .
[77] A. Lee,et al. Mono- and binuclear cyclometallated palladium(II) complexes containing bridging (N,O-) and terminal (N-) imidate ligands: air stable, thermally robust and recyclable catalysts for cross-coupling processes. , 2004, Dalton transactions.
[78] J. Serrano,et al. Palladacyclopentadiene Complexes with Mono- and Didentate Imidato Ligands: Synthesis, Hemilabile Behaviour and Catalytic Application in the Stille Reaction , 2004 .
[79] J. Serrano,et al. Synthesis and characterisation of cyclometallated palladium(II) complexes with phosphine–carboxylate and phosphine–amide ligands , 2003 .
[80] Sebastian Muschelknautz,et al. Flow Reaction Forces upon Blowdown of Safety Valves , 2003 .
[81] J. Mackey,et al. Nucleoside analogues and nucleobases in cancer treatment. , 2002, The Lancet. Oncology.
[82] V. Nair,et al. Novel approaches to functionalized nucleosides via palladium-catalyzed cross coupling with organostannanes , 1987 .
[83] E. W. Moomaw,et al. Preparation of oligodeoxynucleotide-alkaline phosphatase conjugates and their use as hybridization probes. , 1986, Nucleic acids research.
[84] E. De Clercq,et al. Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets. , 1983, Biochemical pharmacology.
[85] C. Schulzke,et al. Pd/PTABS: Low Temperature Thioetherification of Chloro(Hetero)Arenes. , 2019, The Journal of organic chemistry.
[86] M. Lakshman. Synthesis of Biologically Important Nucleoside Analogs by Palladium- Catalyzed C-N Bond-Formation , 2005 .
[87] E. De Clercq. Nucleoside analogues as antiviral agents. , 1981, Acta microbiologica Academiae Scientiarum Hungaricae.