Design of Anti-AIDS Drugs

Perspectives for the chemotherapy of HIV infection: An introduction (E. De Clerq). Toward targeted therapy for HIV infection (H. Mitsuya, T. Shirasaka and S. Broder). HIV-CD4 interaction as target for anti-HIV agents (D. Schols and E. De Clerq). Sulfated polymers as inhibitors of HIV replication (M. Baba and E. De Clercq). Potent and selective inhibition of HIV-1 replication in vitro by a novel series of tetrahydro-imidazo [4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione (TIBO) derivatives (R. Pauwels, K. Andries, J. Desmyter, M.J. Kukla, J. Hyekants, E. De Clercq and P.A.J. Janssen). HIV reverse transcriptase as a target for antiviral drugs (K.L. Powell and G. Darby). Dideoxynucleoside analogues as inhibitors of HIV replication (P. Herdewijn and E. De Clercq). Acyclic and carbocyclic nucleoside analogues as inhibitors of HIV replication (J. Balzarini and E. De Clercq). Antisense oligonucleotides as an approach towards anti-AIDS therapy (J.S. Cohen). HIV-1 protease as a target for potential anti-AIDS drugs (T.D. Meek, D.M. Lambert, B.W. Metcalf, S.R. Petteway, Jr. and G.B. Dreyer). Glycoprotein synthesis and human immunodeficiency viruses: A target for chemotherapy (A.S. Tyms, D.L. Taylor, P.S. Sunkara and M.S. Kang). Animal models for anti-AIDS therapy (R.M. Ruprecht). The clinical use of anti-HIV agents (D.D. Richman). Subject index.