Intravenous Cereport (RMP-7) Enhances Delivery of Hydrophilic Chemotherapeutics and Increases Survival in Rats with Metastatic Tumors in the Brain

[1]  K. Miles,et al.  A simplified technique for measurement of blood-brain barrier permeability using CT: Preliminary results of the effect of RMP-7 , 1996 .

[2]  R K Jain,et al.  Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. , 1994, Cancer research.

[3]  S. Shibata.  Ultrastructure of capillary walls in human brain tumors , 2004, Acta Neuropathologica.

[4]  R. Bartus,et al.  Enhanced delivery of carboplatin into brain tumours with intravenous CereportTM (RMP-7): dramatic differences and insight gained from dosing parameters , 1999, British Journal of Cancer.

[5]  V. Watson,et al.  Intra-arterial administration of carboplatin and the blood brain barrier permeabilizing agent, RMP-7: A toxicologic evaluation in swine , 2004, Journal of Neuro-Oncology.

[6]  P. Parmar,et al.  In Vitro Plasma Metabolism of RMP-7 , 1994, Pharmaceutical Research.

[7]  R. Jain,et al.  Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  T. Cloughesy,et al.  Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. , 1997, Journal of neurosurgery.

[9]  R K Jain,et al.  Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. , 1996, The American journal of pathology.

[10]  K. Black,et al.  Unlocking the Blood–Brain Barrier: A Role for RMP-7 in Brain Tumor Therapy , 1996, Experimental Neurology.

[11]  R. Heller-Harrison,et al.  The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells. , 1994, The Journal of pharmacology and experimental therapeutics.

[12]  T. Cloughesy,et al.  Intra-arterial Cereport (RMP-7) and carboplatin: a dose escalation study for recurrent malignant gliomas. , 1999, Neurosurgery.

[13]  R. Bartus,et al.  Intravenous cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels, and enhances survival. , 2000, The Journal of pharmacology and experimental therapeutics.

[14]  R. Bartus,et al.  Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors. , 1996, Cancer research.

[15]  R. Jain,et al.  Delivery of molecular and cellular medicine to solid tumors. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Bartus Rt.  The blood-brain barrier as a target for pharmacological modulation. , 1999 .

[17]  R K Jain,et al.  Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. , 1999, Cancer research.

[18]  R. Shivers,et al.  Quantitative comparison of the morphology of the microvasculature of primary lung lesions and metastatic brain tumours. , 1998, Journal of submicroscopic cytology and pathology.

[19]  P. J. Elliott,et al.  Controlled Modulation of BBB Permeability Using the Bradykinin Agonist, RMP-7 , 1996, Experimental Neurology.

[20]  Interventional neuroradiology in the treatment of brain tumors. , 1999, Neuroimaging clinics of North America.

[21]  K. Black,et al.  Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors. , 1994, Journal of neurosurgery.

[22]  Ting-Yim Lee,et al.  In vivo CT measurement of blood-brain transfer constant of iopamidol in human brain tumors , 1992, Journal of Neuro-Oncology.

[23]  M. Fukui,et al.  Enhanced tumor uptake of carboplatin and survival in glioma-bearing rats by intracarotid infusion of bradykinin analog, RMP-7. , 1996, Neurosurgery.

[24]  R. Bartus,et al.  Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system. , 1996, Immunopharmacology.

[25]  W. Hall,et al.  Brain metastases: Histology, multiplicity, surgery, and survival , 1996 .

[26]  T. Yamashima,et al.  Placenta growth factor (PlGF) mRNA expression in brain tumors , 1998, Journal of Neuro-Oncology.