Mast Cells in Experimental Skin Carcinogenesis

The changes in the epidermis induced by the application of 20-methylcholanthrene to the skin of mice have been investigated intensively in this hospital. These changes are accompanied by alterations in the dermis and the subcutaneous tissue, one of which is the appearance of numerous cells of various types including mast cells or tissue basophiles. The following account represents a systematic study of the mast cell reaction taking place in mouse skin undergoing the process of methylcholanthrene carcinogenesis.