论文信息 - Biological Activity and Synthesis of an Encephalitogenic Determinant

Biological Activity and Synthesis of an Encephalitogenic Determinant

A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.

[1] R. Shapira,et al. Incomplete deblocking as a cause of failure sequence in solid phase peptide synthesis. , 1971, Journal of the American Chemical Society.

[2] C. E. Stoops,et al. DNA synthesis associated with the inner membrane of the nuclear envelope. , 1971, Nature: New biology.

[3] E. Einstein,et al. Localization of the active site through chemical modification of the encephalitogenic protein. , 1970, The Journal of biological chemistry.

[4] P. Carnegie,et al. Experimental autoimmune encephalomyelitis. Digestion of basic protein of human myelin with cyanogen bromide and trypsin. , 1970, Immunology.

[5] R. Shapira,et al. Encephalitogenic Protein: Structure , 1969, Science.

[6] E. Eylar,et al. Allergic encephalomyelitis: cleavage of the C-tryptophyl bond in the encephalitogenic basic protein from bovne myelin. , 1969, Archives of biochemistry and biophysics.

[7] E. Eylar,et al. Allergic encephalomyelitis: isolation and characterization of encephalitogenic peptides from the basic protein of bovine spinal cord. , 1969, Archives of biochemistry and biophysics.

[8] R. Shapira,et al. Isolation and properties of an encephalitogenic protein from bovine, rabbit, and human central nervous system tissue. , 1968, The Journal of biological chemistry.

[9] A. B. Robinson,et al. Essential Chemical Requirements for Induction of Allergic Encephalomyelitis , 1971, Nature.

[10] M. O. Dayhoff,et al. Atlas of protein sequence and structure , 1965 .