Role of kappa-opioid receptors in stress and anxiety-related behavior

[1]  L. R. Frank Development of Kappa Opioid Receptor Antagonists for Prophylactic Treatment of Migraine , 2014 .

[2]  Y. Shaham,et al.  Recent developments in animal models of drug relapse , 2013, Current Opinion in Neurobiology.

[3]  B. Cohen,et al.  Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity , 2013, Neuropsychopharmacology.

[4]  J. V. Aldrich,et al.  The macrocyclic tetrapeptide [D‐Trp]CJ‐15,208 produces short‐acting κ opioid receptor antagonism in the CNS after oral administration , 2013, British journal of pharmacology.

[5]  P. O’Donnell,et al.  Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion , 2013, Neuropsychopharmacology.

[6]  J. Kauer,et al.  Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity , 2013, Neuron.

[7]  H. de Wit,et al.  Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. , 2013, Drug and alcohol dependence.

[8]  W. Carlezon,et al.  Development of κ opioid receptor antagonists. , 2013, Journal of medicinal chemistry.

[9]  F. Putnam The Role of Abusive States of Being in Interrogation , 2013, Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation.

[10]  W. Carlezon,et al.  Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation. , 2013, Cold Spring Harbor perspectives in medicine.

[11]  Aaron S. Andalman,et al.  Dopamine neurons modulate neural encoding and expression of depression-related behaviour , 2012, Nature.

[12]  K. Deisseroth,et al.  Rapid regulation of depression-related behaviors by control of midbrain dopamine neurons , 2012, Nature.

[13]  Effect of food restriction on cocaine locomotor sensitization in Sprague–Dawley rats , 2013, Psychopharmacology.

[14]  F. Carroll,et al.  Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice , 2013, Psychopharmacology.

[15]  Julia C. Lemos,et al.  Stress Produces Aversion and Potentiates Cocaine Reward by Releasing Endogenous Dynorphins in the Ventral Striatum to Locally Stimulate Serotonin Reuptake , 2012, The Journal of Neuroscience.

[16]  K. Chang,et al.  Interventions for youth at high risk for bipolar disorder and schizophrenia. , 2012, Child and adolescent psychiatric clinics of North America.

[17]  B. Cohen,et al.  Corticotropin-Releasing Factor (CRF)-Induced Disruption of Attention in Rats Is Blocked by the κ-Opioid Receptor Antagonist JDTic , 2012, Neuropsychopharmacology.

[18]  Julia C. Lemos,et al.  Repeated Stress Dysregulates κ-Opioid Receptor Signaling in the Dorsal Raphe through a p38α MAPK-Dependent Mechanism , 2012, The Journal of Neuroscience.

[19]  K. Deisseroth,et al.  Input-specific control of reward and aversion in the ventral tegmental area , 2012, Nature.

[20]  Sulie L. Chang,et al.  Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR. , 2012, Drug and alcohol dependence.

[21]  G. Valdez,et al.  Kappa opioid regulation of anxiety-like behavior during acute ethanol withdrawal , 2012, Pharmacology Biochemistry and Behavior.

[22]  D. Slattery,et al.  Behavioural consequences of two chronic psychosocial stress paradigms: Anxiety without depression , 2012, Psychoneuroendocrinology.

[23]  Alice M Stamatakis,et al.  Presynaptic Inhibition of Gamma-Aminobutyric Acid Release in the Bed Nucleus of the Stria Terminalis by Kappa Opioid Receptor Signaling , 2012, Biological Psychiatry.

[24]  Sarah E. Morris,et al.  Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior , 2012, Dialogues in clinical neuroscience.

[25]  G. Koob,et al.  Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder , 2012, Neuropharmacology.

[26]  K. Ressler,et al.  Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder , 2012, Trends in Neurosciences.

[27]  Anna B. Rachlin,et al.  Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats , 2012, Neuropharmacology.

[28]  M. Bruchas,et al.  Stress-Induced Activation of the Dynorphin/κ-Opioid Receptor System in the Amygdala Potentiates Nicotine Conditioned Place Preference , 2012, The Journal of Neuroscience.

[29]  E. Nestler,et al.  Neurobiology of resilience , 2011, Nature Neuroscience.

[30]  B. Cohen,et al.  Repeated Exposure to the κ-Opioid Receptor Agonist Salvinorin A Modulates Extracellular Signal-Regulated Kinase and Reward Sensitivity , 2011, Biological Psychiatry.

[31]  I. Sora,et al.  Decreased response to social defeat stress in μ-opioid-receptor knockout mice , 2011, Pharmacology Biochemistry and Behavior.

[32]  E. Meloni,et al.  Kappa Opioid Receptor Signaling in the Basolateral Amygdala Regulates Conditioned Fear and Anxiety in Rats , 2011, Biological Psychiatry.

[33]  K. Ressler,et al.  Stress modulation of cognitive and affective processes , 2011, Stress.

[34]  Julia C. Lemos,et al.  Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction , 2011, Neuron.

[35]  Margaret Thompson,et al.  Early detection and intervention for attention-deficit/hyperactivity disorder , 2011, Expert review of neurotherapeutics.

[36]  A. Grace,et al.  Aversive Stimuli Alter Ventral Tegmental Area Dopamine Neuron Activity via a Common Action in the Ventral Hippocampus , 2011, The Journal of Neuroscience.

[37]  E. Meloni,et al.  Activation of CREB in the Nucleus Accumbens Shell Produces Anhedonia and Resistance to Extinction of Fear in Rats , 2011, The Journal of Neuroscience.

[38]  J. McLaughlin,et al.  Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment. , 2011, Journal of addiction research & therapy.

[39]  N. Volkow,et al.  Neurocircuitry of Addiction , 2010, Neuropsychopharmacology.

[40]  Shuang Li,et al.  Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/κ-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms , 2010, Neuropsychopharmacology.

[41]  G. Koob,et al.  Progress in corticotropin-releasing factor-1 antagonist development. , 2010, Drug discovery today.

[42]  M. Bruchas,et al.  Kinase cascades and ligand-directed signaling at the kappa opioid receptor , 2010, Psychopharmacology.

[43]  J. McLaughlin,et al.  Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration , 2010, Psychopharmacology.

[44]  J. L. Howard,et al.  Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement , 2010, Psychopharmacology.

[45]  I. Lucki,et al.  Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats , 2010, Psychopharmacology.

[46]  G. Koob,et al.  The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse , 2010, Psychopharmacology.

[47]  F. Carroll,et al.  Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse , 2010, Psychopharmacology.

[48]  Allison T. Knoll,et al.  Dynorphin, stress, and depression , 2010, Brain Research.

[49]  I. Lucki,et al.  Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats , 2010, Neuropsychopharmacology.

[50]  Mark J. Thomas,et al.  Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis , 2009, Neuropharmacology.

[51]  Julia C. Lemos,et al.  CRF1-R Activation of the Dynorphin/Kappa Opioid System in the Mouse Basolateral Amygdala Mediates Anxiety-Like Behavior , 2009, PloS one.

[52]  A. Bruijnzeel kappa-Opioid receptor signaling and brain reward function , 2009, Brain Research Reviews.

[53]  R. Palmiter,et al.  Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking , 2009, Proceedings of the National Academy of Sciences.

[54]  J. V. Aldrich,et al.  Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action , 2009, Proceedings of the National Academy of Sciences.

[55]  R. Hauger,et al.  Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression , 2009, Annals of the New York Academy of Sciences.

[56]  A. Pittaluga,et al.  Salvinorin A exerts opposite presynaptic controls on neurotransmitter exocytosis from mouse brain nerve terminals , 2009, Neuropharmacology.

[57]  C. Schwarzer 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases. , 2009, Pharmacology & therapeutics.

[58]  G. Koob,et al.  PRECLINICAL STUDY: Corticotropin‐releasing factor‐1 receptor antagonists decrease heroin self‐administration in long‐ but not short‐access rats , 2009, Addiction biology.

[59]  Christopher F. Shay,et al.  Endogenous κ Opioid Activation Mediates Stress-Induced Deficits in Learning and Memory , 2009, The Journal of Neuroscience.

[60]  E. Nestler,et al.  Altered Sensitivity to Rewarding and Aversive Drugs in Mice with Inducible Disruption of cAMP Response Element-Binding Protein Function within the Nucleus Accumbens , 2009, The Journal of Neuroscience.

[61]  C. Schwarzer,et al.  Prodynorphin-Derived Peptides Are Critical Modulators of Anxiety and Regulate Neurochemistry and Corticosterone , 2009, Neuropsychopharmacology.

[62]  Matthew D. Wiley,et al.  κ-Opioid System Regulates the Long-Lasting Behavioral Adaptations Induced by Early-Life Exposure to Methylphenidate , 2008, Neuropsychopharmacology.

[63]  B. Cohen,et al.  The Kappa-Opioid Agonist U69,593 Blocks Cocaine-Induced Enhancement of Brain Stimulation Reward , 2008, Biological Psychiatry.

[64]  H. Covington,et al.  Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake. , 2008, Pharmacology & therapeutics.

[65]  Jennifer M. Mitchell,et al.  Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D2 Receptor Inhibition , 2008, The Journal of Neuroscience.

[66]  M. Ramírez,et al.  Effects of maternal separation on hypothalamic–pituitary–adrenal responses, cognition and vulnerability to stress in adult female rats , 2008, Neuroscience.

[67]  C. Chavkin,et al.  Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system , 2008, Psychopharmacology.

[68]  K. Rice,et al.  Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic–pituitary–adrenal axis in monkeys , 2008, Psychoneuroendocrinology.

[69]  A. Bilkei-Gorzo,et al.  Control of hormonal stress reactivity by the endogenous opioid system , 2008, Psychoneuroendocrinology.

[70]  Artur H. Swiergiel,et al.  Effects of chronic and acute stressors and CRF on depression-like behavior in mice , 2008, Behavioural Brain Research.

[71]  Julia C. Lemos,et al.  The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System , 2008, The Journal of Neuroscience.

[72]  H. Westenberg,et al.  Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder. , 2008, Progress in brain research.

[73]  G. Koob,et al.  CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. , 2008, Psychopharmacology.

[74]  C. Pittenger,et al.  Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms , 2008, Neuropsychopharmacology.

[75]  G. Koob,et al.  CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats , 2008, Psychopharmacology.

[76]  E. Meloni,et al.  Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats , 2007, Journal of Pharmacology and Experimental Therapeutics.

[77]  Stefano Puglisi-Allegra,et al.  The medial prefrontal cortex determines the accumbens dopamine response to stress through the opposing influences of norepinephrine and dopamine. , 2007, Cerebral cortex.

[78]  M. Bruchas,et al.  Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria , 2007, The Journal of Neuroscience.

[79]  L. Parsons,et al.  CRF–CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats , 2007, Proceedings of the National Academy of Sciences.

[80]  M. Bruchas,et al.  Long-Acting κ Opioid Antagonists Disrupt Receptor Signaling And Produce Noncompetitive Effects By Activating C-Jun N-Terminal Kinase* , 2007, Journal of Biological Chemistry.

[81]  J. V. Aldrich,et al.  Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. , 2007, European journal of pharmacology.

[82]  G. Koob,et al.  Stress, dysregulation of drug reward pathways, and the transition to drug dependence. , 2007, The American journal of psychiatry.

[83]  David P. Wolfer,et al.  Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice , 2007, Neurobiology of Learning and Memory.

[84]  Rajita Sinha,et al.  Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals. , 2007, Alcoholism, clinical and experimental research.

[85]  M. Lombès,et al.  The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology , 2007, Nuclear receptor signaling.

[86]  M. Bruchas,et al.  Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. , 2007, The Journal of biological chemistry.

[87]  John T. Williams,et al.  Kappa opioid inhibition of somatodendritic dopamine inhibitory postsynaptic currents. , 2007, Journal of neurophysiology.

[88]  J. Majzoub Corticotropin-releasing hormone physiology , 2006 .

[89]  L. Terenius,et al.  Big Dynorphin, a Prodynorphin-Derived Peptide Produces NMDA Receptor-Mediated Effects on Memory, Anxiolytic-Like and Locomotor Behavior in Mice , 2006, Neuropsychopharmacology.

[90]  John T. Williams,et al.  Properties and Opioid Inhibition of Mesolimbic Dopamine Neurons Vary according to Target Location , 2006, The Journal of Neuroscience.

[91]  M. Bruchas,et al.  Kappa Opioid Receptor Activation of p38 MAPK Is GRK3- and Arrestin-dependent in Neurons and Astrocytes* , 2006, Journal of Biological Chemistry.

[92]  E. Nestler,et al.  The Mesolimbic Dopamine Reward Circuit in Depression , 2006, Biological Psychiatry.

[93]  Shuang Li,et al.  Social Defeat Stress-Induced Behavioral Responses are Mediated by the Endogenous Kappa Opioid System , 2006, Neuropsychopharmacology.

[94]  J. Pintar,et al.  Prior Activation of Kappa Opioid Receptors by U50,488 Mimics Repeated Forced Swim Stress to Potentiate Cocaine Place Preference Conditioning , 2006, Neuropsychopharmacology.

[95]  S. Perrine,et al.  Delta opioid receptor ligands modulate anxiety‐like behaviors in the rat , 2006, British journal of pharmacology.

[96]  C. Schwarzer,et al.  Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain , 2006, Neuropeptides.

[97]  Elyssa B. Margolis,et al.  Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[98]  Danielle L. Graham,et al.  Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress , 2006, Science.

[99]  Cécile Béguin,et al.  Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats , 2006, Journal of Pharmacology and Experimental Therapeutics.

[100]  James P. Herman,et al.  Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[101]  I. Kovalenko,et al.  A Model of Anxious Depression: Persistence of Behavioral Pathology , 2005, Neuroscience and Behavioral Physiology.

[102]  M. Hiramatsu,et al.  Improvement of memory impairment by (+)- and (−)-pentazocine via sigma, but not kappa opioid receptors , 2005, Brain Research.

[103]  James L. Howard,et al.  Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats , 2005, Psychopharmacology.

[104]  Y. Hurd,et al.  Prodynorphin transcripts and proteins differentially expressed and regulated in the adult human brain , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[105]  E. Nestler,et al.  The many faces of CREB , 2005, Trends in Neurosciences.

[106]  C. Coscia,et al.  μ and κ Opioid Receptors Activate ERK/MAPK via Different Protein Kinase C Isoforms and Secondary Messengers in Astrocytes* , 2005, Journal of Biological Chemistry.

[107]  T. Foster,et al.  Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance , 2005, Behavioural Brain Research.

[108]  Elyssa B. Margolis,et al.  Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. , 2005, Journal of neurophysiology.

[109]  Michael Rickels,et al.  Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants , 1995, Psychopharmacology.

[110]  J. Stewart,et al.  Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal , 1995, Psychopharmacology.

[111]  C. Coscia,et al.  Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. , 2005, The Journal of biological chemistry.

[112]  E. Bennett,et al.  Kappa opioid receptor activity modulates memory for peck-avoidance training in the 2-day-old chick , 2005, Psychopharmacology.

[113]  M. Hiramatsu,et al.  Involvement of κ-opioid receptors and σ receptors in memory function demonstrated using an antisense strategy , 2004, Brain Research.

[114]  J. Feldon,et al.  Mesolimbic dopaminergic pathways in fear conditioning , 2004, Progress in Neurobiology.

[115]  N. Volkow,et al.  Drug addiction: the neurobiology of behaviour gone awry , 2004, Nature Reviews Neuroscience.

[116]  H. Loh,et al.  Altered emotional behaviors and the expression of 5‐HT1A and M1 muscarinic receptors in μ‐opioid receptor knockout mice , 2004, Synapse.

[117]  Masaaki Iwata,et al.  Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant‐like effects , 2004, Journal of neurochemistry.

[118]  Angel Y. F. Kam,et al.  κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells , 2004, Journal of Pharmacology and Experimental Therapeutics.

[119]  Larry W Swanson,et al.  Projections from bed nuclei of the stria terminalis, posterior division: Implications for cerebral hemisphere regulation of defensive and reproductive behaviors , 2004, The Journal of comparative neurology.

[120]  James B. Thomas,et al.  Importance of phenolic address groups in opioid kappa receptor selective antagonists. , 2004, Journal of medicinal chemistry.

[121]  H. Covington,et al.  Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits , 2004, Neuroscience & Biobehavioral Reviews.

[122]  M. Todtenkopf,et al.  Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats. , 2004, Psychopharmacology.

[123]  M. Hiramatsu,et al.  Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy. , 2004, Brain research.

[124]  M. Todtenkopf,et al.  Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats , 2004, Psychopharmacology.

[125]  Elyssa B. Margolis,et al.  κ-Opioid Agonists Directly Inhibit Midbrain Dopaminergic Neurons , 2003, The Journal of Neuroscience.

[126]  K. Mackie,et al.  Phosphorylation of a Carboxyl-terminal Serine within the κ-Opioid Receptor Produces Desensitization and Internalization* , 2003, Journal of Biological Chemistry.

[127]  C. Chavkin,et al.  κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses , 2003, The Journal of Neuroscience.

[128]  H. Fields,et al.  Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms. , 2003, Journal of neurophysiology.

[129]  Philip S. Portoghese,et al.  Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats , 2003, Journal of Pharmacology and Experimental Therapeutics.

[130]  T. Day,et al.  Medial prefrontal cortex suppression of the hypothalamic–pituitary–adrenal axis response to a physical stressor, systemic delivery of interleukin‐1β , 2003 .

[131]  J. Roder,et al.  Differential involvement of the Mu and Kappa opioid receptors in spatial learning , 2003, Genes, brain, and behavior.

[132]  S. Andersen Trajectories of brain development: point of vulnerability or window of opportunity? , 2003, Neuroscience & Biobehavioral Reviews.

[133]  L. D. van de Kar,et al.  Neuroendocrine pharmacology of stress. , 2003, European journal of pharmacology.

[134]  Michael Davis,et al.  Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. , 2003, European journal of pharmacology.

[135]  T. Day,et al.  Medial prefrontal cortex suppression of the hypothalamic-pituitary-adrenal axis response to a physical stressor, systemic delivery of interleukin-1beta. , 2003, The European journal of neuroscience.

[136]  Yan Zhang,et al.  Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. , 2003, The Journal of pharmacology and experimental therapeutics.

[137]  Elyssa B. Margolis,et al.  Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. , 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[138]  Eric J. Nestler,et al.  Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect , 2002, The Journal of Neuroscience.

[139]  D. Doudet,et al.  Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[140]  C. Tsigos,et al.  Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. , 2002, Journal of psychosomatic research.

[141]  T. Robbins,et al.  The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry , 2002, Psychopharmacology.

[142]  Rachael L Neve,et al.  CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[143]  J. Herman,et al.  Neurocircuitry of Stress Integration: Anatomical Pathways Regulating the Hypothalamo-Pituitary-Adrenocortical Axis of the Rat1 , 2002, Integrative and comparative biology.

[144]  F. Holsboer,et al.  Effects of transgenic overproduction of CRH on anxiety‐like behaviour , 2002, The European journal of neuroscience.

[145]  G. Griebel,et al.  4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II. Characterization in rodent models of stress-related , 2002, The Journal of pharmacology and experimental therapeutics.

[146]  R. Hauger,et al.  The CRF peptide family and their receptors: yet more partners discovered. , 2002, Trends in pharmacological sciences.

[147]  D. Pine,et al.  Adolescent life events as predictors of adult depression. , 2002, Journal of affective disorders.

[148]  R. Bandler,et al.  Parallel circuits mediating distinct emotional coping reactions to different types of stress , 2001, Neuroscience & Biobehavioral Reviews.

[149]  E. Nestler,et al.  Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens , 2001, The Journal of Neuroscience.

[150]  Hong-wei Dong,et al.  Basic organization of projections from the oval and fusiform nuclei of the bed nuclei of the stria terminalis in adult rat brain , 2001, The Journal of comparative neurology.

[151]  D. Baker,et al.  Corticotropin-releasing hormone in depression and post-traumatic stress disorder , 2001, Peptides.

[152]  L. Bohn,et al.  Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade. , 2001, Journal of neurochemistry.

[153]  P. Sawchenko,et al.  Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse , 2000, The Journal of comparative neurology.

[154]  R. Kessler,et al.  The epidemiology of pure and comorbid generalized anxiety disorder: a review and evaluation of recent research , 2000, Acta psychiatrica Scandinavica. Supplementum.

[155]  N. Goeders,et al.  Effects of the CRH Receptor Antagonist CP-154,526 on Intravenous Cocaine Self-administration in Rats , 2000, Neuropsychopharmacology.

[156]  A. Dierich,et al.  Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses , 2000, Nature Genetics.

[157]  G. Chrousos,et al.  Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[158]  A. Dierich,et al.  Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. , 2000, Nature genetics.

[159]  H. Loh,et al.  Molecular mechanisms and regulation of opioid receptor signaling. , 2000, Annual review of pharmacology and toxicology.

[160]  D. Charney,et al.  Comorbidity of mood and anxiety disorders , 2000, Depression and anxiety.

[161]  S. Hogg,et al.  Behavioural consequences of repeated social defeat in the mouse: preliminary evaluation of a potential animal model of depression. , 1999, Behavioural pharmacology.

[162]  G. Koob,et al.  Corticotropin-releasing factor, norepinephrine, and stress , 1999, Biological Psychiatry.

[163]  T. Day,et al.  The central amygdala modulates hypothalamic–pituitary–adrenal axis responses to systemic interleukin-1β administration , 1999, Neuroscience.

[164]  K. O’Malley,et al.  κ-Opioid Tolerance and Dependence in Cultures of Dopaminergic Midbrain Neurons , 1999, The Journal of Neuroscience.

[165]  G. Koob,et al.  Corticotropin-releasing factor antagonist attenuates the “anxiogenic-like” effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats , 1999, Psychopharmacology.

[166]  J. Crabbe,et al.  Genetics of mouse behavior: interactions with laboratory environment. , 1999, Science.

[167]  K. Kendler,et al.  Causal relationship between stressful life events and the onset of major depression. , 1999, The American journal of psychiatry.

[168]  S. West,et al.  Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. , 1999, The American journal of psychiatry.

[169]  S. Maier,et al.  The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress * , 1998 .

[170]  N. Hiroi,et al.  Regulation of cocaine reward by CREB. , 1998, Science.

[171]  F. Holsboer,et al.  Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 , 1998, Nature Genetics.

[172]  G. Koob,et al.  Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development , 1998, Neuron.

[173]  M. Le Moal,et al.  The role of stress in drug self-administration. , 1998, Trends in pharmacological sciences.

[174]  B. Roques,et al.  Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal , 1998, The EMBO journal.

[175]  Z. Vogel,et al.  Opioid Modulation of Extracellular Signal‐Regulated Protein Kinase Activity Is Ras‐Dependent and Involves Gβγ Subunits , 1998 .

[176]  Z. Vogel,et al.  Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits. , 1998, Journal of neurochemistry.

[177]  E. Stuenkel,et al.  κ-Opioid Receptor Activation Modulates Ca2+Currents and Secretion in Isolated Neuroendocrine Nerve Terminals , 1997, The Journal of Neuroscience.

[178]  J. Li,et al.  Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. , 1997, The Journal of pharmacology and experimental therapeutics.

[179]  I. Merchenthaler,et al.  In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat , 1997, The Journal of comparative neurology.

[180]  S. Southwick,et al.  Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. , 1997, The American journal of psychiatry.

[181]  S. Turgeon,et al.  Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization , 1997, Brain Research.

[182]  E. Ur,et al.  The effects of spiradoline (U‐62066E), a κ‐opioid receptor agonist, on neuroendocrine function in man , 1997, British journal of pharmacology.

[183]  R. Kessler,et al.  The effects of stressful life events on depression. , 1997, Annual review of psychology.

[184]  Michael Davis,et al.  Neurobiology of fear responses: the role of the amygdala. , 1997, The Journal of neuropsychiatry and clinical neurosciences.

[185]  T. Kameyama,et al.  U-50488H, a selective kappa-opioid receptor agonist, improves carbon monoxide-induced delayed amnesia in mice. , 1996, European journal of pharmacology.

[186]  M. Morimoto,et al.  Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study , 1996, Neuroscience Research.

[187]  L. Swanson,et al.  Organization of projections from the basomedial nucleus of the amygdala: A PHAL study in the rat , 1996, The Journal of comparative neurology.

[188]  S. Scaccianoce,et al.  The Kappa‐Opioid Receptor Agonist MR‐2034 Stimulates the Rat Hypothalamic‐Pituitary‐Adrenal Axis: Studies in vivo and in vitro , 1996, Journal of neuroendocrinology.

[189]  R. Sapolsky,et al.  Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion. , 1996, Stress.

[190]  C. Chavkin,et al.  k-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. , 1996, Molecular pharmacology.

[191]  Y. Hurd,et al.  Differential messenger RNA expression of prodynorphin and proenkephalin in the human brain , 1996, Neuroscience.

[192]  B. Bloch,et al.  kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[193]  S. Hyman,et al.  Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum , 1995, Neuron.

[194]  Z. Sarnyai,et al.  Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats , 1995, Brain Research.

[195]  D. Grandy,et al.  Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. , 1995, Molecular pharmacology.

[196]  S. Lukas,et al.  Buprenorphine treatment of refractory depression. , 1995, Journal of clinical psychopharmacology.

[197]  Chongguang Chen,et al.  Cloning of a human κ opioid receptor from the brain , 1995 .

[198]  G. Koob,et al.  Suppression of corticotropin‐releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal , 1995, Behavioural pharmacology.

[199]  L. Swanson,et al.  Organization of projections from the medial nucleus of the amygdala: A PHAL study in the rat , 1995, The Journal of comparative neurology.

[200]  E. D. De Souza,et al.  Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. , 1995, Psychoneuroendocrinology.

[201]  C. Chen,et al.  Cloning of a human kappa opioid receptor from the brain. , 1995, Life sciences.

[202]  M. Dichter,et al.  The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells , 1994, Neuroscience.

[203]  K. Fuxe,et al.  Mapping and computer assisted morphometry and microdensitometry of glucocorticoid receptor immunoreactive neurons and glial cells in the rat central nervous system , 1994, Neuroscience.

[204]  G. Koob,et al.  Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[205]  J. Salamone The involvement of nucleus accumbens dopamine in appetitive and aversive motivation , 1994, Behavioural Brain Research.

[206]  J. Douglass,et al.  Identification of multiple DNA elements regulating basal and protein kinase A-induced transcriptional expression of the rat prodynorphin gene. , 1994, Molecular endocrinology.

[207]  P. J. Brown,et al.  Substance abuse and post-traumatic stress disorder comorbidity. , 1994, Drug and alcohol dependence.

[208]  A Goldstein,et al.  Cloning and pharmacological characterization of a rat kappa opioid receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[209]  J. Bidlack,et al.  The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein. , 1993, The Journal of pharmacology and experimental therapeutics.

[210]  J. Herman,et al.  Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis , 1993, The Journal of comparative neurology.

[211]  G. Koob,et al.  Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal , 1993, Brain Research.

[212]  S. Sesack,et al.  Cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra , 1993, Brain Research.

[213]  Stefano Puglisi-Allegra,et al.  Repeated stressful experiences differently affect the time-dependent responses of the mesolimbic dopamine system to the stressor , 1993, Brain Research.

[214]  E. Ronken,et al.  Opioid receptor-mediated inhibition of evoked catecholamine release from cultured neurons of rat ventral mesencephalon and locus coeruleus. , 1993, European journal of pharmacology.

[215]  S. Childers,et al.  Relationship between kappa 1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes. , 1993, Biochemical pharmacology.

[216]  T. Shippenberg,et al.  Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. , 1993, The Journal of pharmacology and experimental therapeutics.

[217]  C. Nemeroff,et al.  The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: implications for a role for CRF in the pathogenesis of anxiety disorders. , 1993, Journal of psychiatric research.

[218]  G F Koob,et al.  The role of corticotropin-releasing factor in behavioural responses to stress. , 1993, Ciba Foundation symposium.

[219]  A. Takemori,et al.  Stimulation by corticotropin-releasing factor of the release of immunoreactive dynorphin A from mouse spinal cords in vitro. , 1992, European journal of pharmacology.

[220]  B. Rothbaum,et al.  Uncontrollability and unpredictability in post-traumatic stress disorder: an animal model. , 1992, Psychological bulletin.

[221]  M. Davis,et al.  Corticotropin-releasing factor: long-lasting facilitation of the acoustic startle reflex , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[222]  Declan Jones,et al.  Long term κ-opioid receptor blockade following nor-binaltorphimine , 1992 .

[223]  J. Singer,et al.  Stability/Instability of Cognitive Strategies Across Tasks Determine Whether Stress Will Affect Judgmental Processes' , 1992 .

[224]  G. Chrousos,et al.  The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. , 1992, JAMA.

[225]  T. Endoh,et al.  Nor-binaltorphimine: a potent and selective kappa-opioid receptor antagonist with long-lasting activity in vivo. , 1992, Archives internationales de pharmacodynamie et de therapie.

[226]  H. Yamamura,et al.  Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test. , 1992, The Journal of pharmacology and experimental therapeutics.

[227]  W. Haefely,et al.  Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats , 1992, European Neuropsychopharmacology.

[228]  C. Nemeroff New vistas in neuropeptide research in neuropsychiatry: focus on corticotropin-releasing factor. , 1992, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[229]  D. Jones,et al.  Long term kappa-opioid receptor blockade following nor-binaltorphimine. , 1992, European journal of pharmacology.

[230]  R. Spanagel,et al.  Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[231]  H. Anisman,et al.  Stressor-induced anhedonia in the mesocorticolimbic system , 1991, Neuroscience & Biobehavioral Reviews.

[232]  R. Ahima,et al.  Charting of Type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system , 1990, Neuroscience.

[233]  M. Branchey,et al.  Duration and Intensity of Combat Exposure and Posttraumatic Stress Disorder in Vietnam Veterans , 1990, The Journal of nervous and mental disease.

[234]  R. Gross,et al.  Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[235]  R. G. Allen,et al.  Corticotropin-releasing factor differentially regulates anterior and intermediate pituitary lobe proopiomelanocortin gene transcription, nuclear precursor RNA and mature mRNA in vivo. , 1990, Neuroendocrinology.

[236]  M. Takahashi,et al.  Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia. , 1990, Japanese journal of pharmacology.

[237]  T. Gray,et al.  Direct projections from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: possible role in stress-induced adrenocorticotropin release. , 1989, Neuroendocrinology.

[238]  S. Childers,et al.  Dynorphin-selective inhibition of adenylyl cyclase in guinea pig cerebellum membranes. , 1989, Molecular pharmacology.

[239]  H. Akil,et al.  Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[240]  L. Swanson,et al.  Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: A hybridization histochemical study in the rat , 1989, The Journal of comparative neurology.

[241]  D. Sirinathsinghji,et al.  Corticotropin-releasing factor stimulates the release of methionine-enkephalin and dynorphin from the neostriatum and globus pallidus of the rat: in vitro and in vivo studies , 1989, Brain Research.

[242]  E. Abercrombie,et al.  Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex , 1989, Journal of neurochemistry.

[243]  B. Attali,et al.  K‐Opiate Agonists Inhibit Adenylate Cyclase and Produce Heterologous Desensitization in Rat Spinal Cord , 1989 .

[244]  C. Nemeroff,et al.  Elevated CSF CRF in suicide victims , 1989, Biological Psychiatry.

[245]  M. E. Lewis,et al.  Anatomy of CNS opioid receptors , 1988, Trends in Neurosciences.

[246]  R. Wise,et al.  Effects of naltrexone on nucleus accumbens, lateral hypothalamic and ventral tegmental self-stimulation rate—frequency functions , 1988, Brain Research.

[247]  E. Gelpí,et al.  Time course of changes in serotonin and noradrenaline in rat brain after predictable or unpredictable shock , 1988, Brain Research.

[248]  P. Portoghese,et al.  Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs. , 1988, The Journal of pharmacology and experimental therapeutics.

[249]  C. Nemeroff,et al.  Monoamine metabolites, corticotropin releasing factor and somatostatin as CSF markers in depressed patients. , 1988, Journal of affective disorders.

[250]  G. Di Chiara,et al.  Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. , 1988, The Journal of pharmacology and experimental therapeutics.

[251]  R. Wise,et al.  A psychomotor stimulant theory of addiction. , 1987, Psychological review.

[252]  G. Stalla,et al.  The role of CRF in the release of ACTH by opiate agonists and antagonists in rats , 1987, Brain Research.

[253]  H. Akil,et al.  Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain , 1987 .

[254]  M. Sakanaka,et al.  Corticotropin releasing factor‐like immunoreactivity in the rat brain as revealed by a modified cobalt‐glucose oxidase‐diaminobenzidine method , 1987, The Journal of comparative neurology.

[255]  S. File,et al.  Corticotropin-releasing factor has an anxiogenic action in the social interaction test , 1987, Hormones and Behavior.

[256]  G. Keinan Decision making under stress: scanning of alternatives under controllable and uncontrollable threats. , 1987, Journal of personality and social psychology.

[257]  T. Di Paolo,et al.  Participation of the central amygdaloid nucleus in the response of adrenocorticotropin secretion to immobilization stress: opposing roles of the noradrenergic and dopaminergic systems. , 1987, Neuroendocrinology.

[258]  A. Herz,et al.  Stimulation of hypothalamic β-endorphin and dynorphin release by corticotropin-releasing factor (in vitro) , 1986, Brain Research.

[259]  F. Antoni,et al.  Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. , 1986, Endocrine reviews.

[260]  H. Emrich,et al.  Psychotomimesis mediated by kappa opiate receptors , 1986, Science.

[261]  B. Morris,et al.  Localization of prodynorphin messenger RNA in rat brain by in situ hybridization using a synthetic oligonucleotide probe , 1986, Neuroscience Letters.

[262]  H. Kim,et al.  Kappa opiate agonists modulate the hypothalamic-pituitary-adrenocortical axis in the rat. , 1986, The Journal of pharmacology and experimental therapeutics.

[263]  J. Fallon,et al.  Distribution of dynorphin and enkephalin peptides in the rat brain , 1986, The Journal of comparative neurology.

[264]  J. Buckingham,et al.  Pharmacological characterization of opioid receptors influencing the secretion of corticotrophin releasing factor in the rat. , 1986, Neuroendocrinology.

[265]  G. Koob,et al.  Corticotropin releasing factor (CRF) receptor antagonist blocks activating and ‘anxiogenic’ actions of CRF in the rat , 1986, Brain Research.

[266]  D. Jacobowitz,et al.  Distribution of corticotropin-releasing factor receptors in primate brain. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[267]  A. Herz,et al.  Regulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (CRF). , 1986, NIDA research monograph.

[268]  E. R. Kloet,et al.  Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. , 1985, Endocrinology.

[269]  T. Insel,et al.  Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[270]  K. Fuxe,et al.  Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor. , 1985, Endocrinology.

[271]  B. Stewart,et al.  Effect of μ and κ opioid receptor agonists on rat plasma corticosterone levels , 1985 .

[272]  B. Stewart,et al.  Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels. , 1985, European journal of pharmacology.

[273]  I. Merchenthaler,et al.  Corticotropin releasing factor (CRF)-like immunoreactivity in the rat central nervous system. Extrahypothalamic distribution , 1984, Peptides.

[274]  C. Kilts,et al.  Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. , 1984, Science.

[275]  A. Goldstein,et al.  Opioid receptor selectivity of dynorphin gene products. , 1984, The Journal of pharmacology and experimental therapeutics.

[276]  N. Holbrook,et al.  Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. , 1984, Endocrine reviews.

[277]  L. Swanson,et al.  Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. , 1983, Neuroendocrinology.

[278]  J S Schwaber,et al.  Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[279]  J. E. Platt,et al.  Chronic restraint stress elicits a positive antidepressant response on the forced swim test. , 1982, European journal of pharmacology.

[280]  G. Koob,et al.  Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. , 1982, Life sciences.

[281]  L. Swanson,et al.  The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat , 1982, Brain Research Bulletin.

[282]  C. Chavkin,et al.  Dynorphin is a specific endogenous ligand of the kappa opioid receptor. , 1982, Science.

[283]  W. Vale,et al.  Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. , 1982, Science.

[284]  W. Vale,et al.  Primary structure of corticotropin-releasing factor from ovine hypothalamus. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[285]  W. Vale,et al.  Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin , 1981 .

[286]  R. Porsolt,et al.  Depression: a new animal model sensitive to antidepressant treatments , 1977, Nature.

[287]  I. Janis,et al.  Decision Making: A Psychological Analysis of Conflict, Choice, and Commitment , 1977 .

[288]  J. Glowinski,et al.  Selective activation of the mesocortical DA system by stress , 1976, Nature.

[289]  B. Pitt Psychopharmacology , 1968, Mental Health.

[290]  S. J. Beck Review of The Blacky Pictures. , 1956 .

[291]  H E ROSVOLD,et al.  A continuous performance test of brain damage. , 1956, Journal of consulting psychology.