Projections of AIDS morbidity and mortality in San Francisco.

To develop a model for predicting acquired immunodeficiency syndrome (AIDS) morbidity in San Francisco, Calif, through June 1993, we combined annual human immunodeficiency virus seroconversion rates for homosexual and bisexual men and for heterosexual intravenous drug users with estimates of the cumulative proportion of the population with AIDS by duration of human immunodeficiency virus infection and with estimates of the size of the at-risk populations. We projected AIDS mortality by applying Kaplan-Meier estimates of survival time following diagnosis to the projected number of cases. The median incubation period for AIDS among homosexual and bisexual men infected with the human immunodeficiency virus was estimated to be 11.0 years (mean, 11.8 years; 95% confidence interval, 10.6 to 13.0 years). The model projects 12,349 to 17,022 cumulative cases of AIDS in San Francisco through June 1993, with 9,966 to 12,767 cumulative deaths.

[1]  G. Rutherford,et al.  Prevalence, incidence, and progression of human immunodeficiency virus infection in homosexual and bisexual men in hepatitis B vaccine trials, 1978-1988. , 1989, American journal of epidemiology.

[2]  J. Ward,et al.  Statistical analysis of the stages of HIV infection using a Markov model. , 1989, Statistics in medicine.

[3]  Peter Bacchetti,et al.  Incubation period of AIDS in San Francisco , 1989, Nature.

[4]  R. Chaisson,et al.  Cocaine use and HIV infection in intravenous drug users in San Francisco. , 1989, JAMA.

[5]  G. Rutherford,et al.  The natural history of human immunodeficiency virus infection. , 1988, The Journal of infectious diseases.

[6]  W Winkelstein,et al.  The San Francisco Men's Health Study: continued decline in HIV seroconversion rates among homosexual/bisexual men. , 1988, American journal of public health.

[7]  G. Rutherford,et al.  A model-based estimate of the mean incubation period for AIDS in homosexual men. , 1988, Science.

[8]  J. Newmeyer.  The prevalence of drug use in San Francisco in 1987. , 1988, Journal of psychoactive drugs.

[9]  R. Chaisson,et al.  Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort , 1988, British medical journal.

[10]  Mossadeq Ar,et al.  AIDS and intravenous drug use in San Francisco. , 1988 .

[11]  V. De Gruttola,et al.  Assessing and modeling heterosexual spread of the human immunodeficiency virus in the United States. , 1988, Reviews of Infectious Diseases.

[12]  J. Levy,et al.  The San Francisco Men's Health Study: III. Reduction in human immunodeficiency virus transmission among homosexual/bisexual men, 1982-86. , 1987, American journal of public health.

[13]  R. Anderson,et al.  IS IT POSSIBLE TO PREDICT THE MINIMUM SIZE OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) EPIDEMIC IN THE UNITED KINGDOM? , 1987, The Lancet.

[14]  A. Ra,et al.  AIDS in Europe: current trends and short-term predictions estimated from surveillance data, January 1981-June 1986. , 1987 .

[15]  Roy M. Anderson,et al.  Transmission dynamics of HIV infection , 1987, Nature.

[16]  R. Chaisson,et al.  Human immunodeficiency virus infection in heterosexual intravenous drug users in San Francisco. , 1987, American journal of public health.

[17]  J. Levy,et al.  Clinical, immunologic, and serologic findings in men at risk for acquired immunodeficiency syndrome. The San Francisco Men's Health Study. , 1987, JAMA.

[18]  J. Levy,et al.  Sexual practices and risk of infection by the human immunodeficiency virus. The San Francisco Men's Health Study. , 1987, JAMA.

[19]  Ron Brookmeyer,et al.  MINIMUM SIZE OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) EPIDEMIC IN THE UNITED STATES , 1986, The Lancet.

[20]  R. Detels,et al.  The time from infection with human immunodeficiency virus (HIV) to the onset of AIDS. , 1986, The Journal of infectious diseases.

[21]  Morgan Wm,et al.  Acquired immunodeficiency syndrome: current and future trends. , 1986, Public health reports.

[22]  Susan E. Wilson,et al.  Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. , 1986, Science.

[23]  J. Pickering,et al.  Modeling the incidence of Acquired Immunodeficiency Syndrome (AIDS) in San Francisco, Los Angeles, and New York , 1986 .

[24]  T. Coates,et al.  Reported changes in the sexual behavior of men at risk for AIDS, San Francisco, 1982-84--the AIDS Behavioral Research Project. , 1985, Public health reports.

[25]  M. Mcevoy,et al.  SOME PROBLEMS IN THE PREDICTION OF FUTURE NUMBERS OF CASES OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN THE UK , 1985, The Lancet.

[26]  S. Hadler,et al.  The prevention of hepatitis B with vaccine. Report of the centers for disease control multi-center efficacy trial among homosexual men. , 1982, Annals of internal medicine.