Attenuation of TNF‐induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho‐GTPase activity, p50 activity and morphological changes

[1]  G. Kitas,et al.  The Role of Statins in Disease Modification and Cardiovascular Risk in Rheumatoid Arthritis , 2018, Front. Med..

[2]  M. Targosz-Korecka,et al.  Nanomechanical testing of drug activities at the cellular level: Case study for endothelium-targeted drugs , 2017, Pharmacological reports : PR.

[3]  C. P. Vicente,et al.  TNF induces neutrophil adhesion via formin‐dependent cytoskeletal reorganization and activation of β‐integrin function , 2017, Journal of leukocyte biology.

[4]  E. Vichinsky,et al.  Simvastatin reduces vaso‐occlusive pain in sickle cell anaemia: a pilot efficacy trial , 2017, British journal of haematology.

[5]  Qiang Zhou,et al.  Statin and Aspirin Pretreatment Are Associated with Lower Neurological Deterioration and Platelet Activity in Patients with Acute Ischemic Stroke. , 2017, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[6]  M. Teixeira,et al.  Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment. , 2016, Pharmacological research.

[7]  J. Chung,et al.  Simvastatin induces the apoptosis of normal vascular smooth muscle through the disruption of actin integrity via the impairment of RhoA/ Rac-1 activity , 2016, Thrombosis and Haemostasis.

[8]  Anna Huttenlocher,et al.  Neutrophil migration in infection and wound repair: going forward in reverse , 2016, Nature Reviews Immunology.

[9]  F. Montecucco,et al.  Role of neutrophils in atherogenesis: an update , 2016, European journal of clinical investigation.

[10]  D. Covas,et al.  Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea. , 2015, Blood.

[11]  Bin-Nan Wu,et al.  Atorvastatin prevents neuroinflammation in chronic constriction injury rats through nuclear NFκB downregulation in the dorsal root ganglion and spinal cord. , 2015, ACS chemical neuroscience.

[12]  J. Wallmichrath,et al.  Simvastatin reduces leucocyte– and platelet–endothelial cell interaction in murine antigen-induced arthritis in vivo , 2014, Scandinavian journal of rheumatology.

[13]  S. Matsufuji,et al.  Rho-kinase regulation of TNF-α-induced nuclear translocation of NF-κB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells. , 2014, American journal of physiology. Renal physiology.

[14]  Wenpeng Li,et al.  Simvastatin Inhibits Inflammation in Ischemia-Reperfusion Injury , 2014, Inflammation.

[15]  V. Tergaonkar,et al.  Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology , 2014, Bioscience reports.

[16]  J. Hošek,et al.  TNF-α signalling and inflammation: interactions between old acquaintances , 2013, Inflammation Research.

[17]  F. Costa,et al.  Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity , 2013, Inflammation Research.

[18]  Sumihiko Hagita,et al.  In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin , 2012, BioMed research international.

[19]  Oliver Soehnlein,et al.  Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation , 2012, PloS one.

[20]  H. Dyson,et al.  Role of disorder in IκB–NFκB interaction , 2012, IUBMB life.

[21]  D. Sin,et al.  Endotoxin-induced cardiovascular dysfunction in mice: effect of simvastatin. , 2011, Journal of applied physiology.

[22]  M. Cendoroglo Neto,et al.  Effects of simvastatin on cytokines secretion from mononuclear cells from critically ill patients with acute kidney injury. , 2011, Cytokine.

[23]  K. Goss,et al.  Priming of Neutrophils and Differentiated PLB-985 Cells by Pathophysiological Concentrations of TNF-α Is Partially Oxygen Dependent , 2010, Journal of Innate Immunity.

[24]  S. Filetti,et al.  Atorvastatin Downregulates Monocyte CD36 Expression, Nuclear NFκB and TNFα Levels in Type 2 Diabetes , 2010 .

[25]  S. Homer-Vanniasinkam,et al.  Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow. , 2008, Atherosclerosis.

[26]  T. Mayadas,et al.  Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes , 2008, Journal of leukocyte biology.

[27]  F. Mach,et al.  Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways. , 2008, Cellular signalling.

[28]  M. Rekhter,et al.  Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice , 2008, Biomarker Insights.

[29]  Nihal Ahmad,et al.  Dose translation from animal to human studies revisited , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  M. Lokuta,et al.  TNF‐α promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway , 2005 .

[31]  Nastaran Zahir,et al.  Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors , 2003, The Journal of cell biology.

[32]  J. Liao,et al.  A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms , 2003, Annals of medicine.

[33]  J. Harlan,et al.  Requirement for RhoA Kinase Activation in Leukocyte De-Adhesion1 , 2002, The Journal of Immunology.

[34]  B. Coller,et al.  Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Fortenberry,et al.  S-nitrosoglutathione inhibits TNF-α-induced NFκB activation in neutrophils , 2001, Inflammation Research.

[36]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[37]  B. Petri,et al.  Neutrophil chemotaxis , 2017, Cell and Tissue Research.

[38]  Nastaran Zahir,et al.  Autocrine laminin-5 ligates { alpha } 6 { beta } 4 integrin and activates RAC and NF { kappa } B to mediate anchorange-independent survival of mammary tumors , 2014 .

[39]  Hao Wu,et al.  Structural basis of signal transduction in the TNF receptor superfamily. , 2013, Advances in immunology.

[40]  S. Filetti,et al.  Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes. , 2010, Journal of atherosclerosis and thrombosis.

[41]  M. Lokuta,et al.  TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. , 2005, Journal of leukocyte biology.