CuO nanowire/microflower/nanowire modified Cu electrode with enhanced electrochemical performance for non-enzymatic glucose sensing

CuO nanowire/microflower structure on Cu foil is synthesized by annealing a Cu(OH)2 nanowire/CuO microflower structure at 250 °C in air. The nanowire/microflower structure with its large surface area leads to an efficient catalysis and charge transfer in glucose detection, achieving a high sensitivity of 1943 μA mM(-1) cm(-2), a wide linear range up to 4 mM and a low detection limit of 4 μM for amperometric glucose sensing in alkaline solution. With a second consecutive growth of CuO nanowires on the microflowers, the sensitivity of the obtained CuO nanowire/microflower/nanowire structure further increases to 2424 μA mM(-1) cm(-2), benefiting from an increased number of electrochemically active sites. The enhanced electrocatalytic performance of the CuO nanowire/microflower/nanowire electrode compared to the CuO nanowire/microflower electrode, CuO nanowire electrode and CuxO film electrode provides evidence for the significant role of available surface area for electrocatalysis. The rational combination of CuO nanowire and microflower nanostructures into a nanowire supporting microflower branching nanowires structure makes it a promising composite nanostructure for use in CuO based electrochemical sensors with promising analytical properties.

[1]  E. Gyenge,et al.  Electrocatalysis of borohydride oxidation: a review of density functional theory approach combined with experimental validation , 2014, Journal of physics. Condensed matter : an Institute of Physics journal.

[2]  M. Balkanski,et al.  Light Scattering and Infrared Absorption in Cuprous Oxide , 1972 .

[3]  Jae-Joon Lee,et al.  A Comprehensive Review of Glucose Biosensors Based on Nanostructured Metal-Oxides , 2010, Sensors.

[4]  Feng Yan,et al.  The improvement of glucose bioelectrocatalytic properties of platinum electrodes modified with electrospun TiO2 nanofibers. , 2010, Biosensors & bioelectronics.

[5]  Z.L. Wang,et al.  Single‐Crystalline Scroll‐Type Nanotube Arrays of Copper Hydroxide Synthesized at Room Temperature , 2003 .

[6]  Dan Xiao,et al.  An improved sensitivity non-enzymatic glucose sensor based on a CuO nanowire modified Cu electrode. , 2008, The Analyst.

[7]  W. S. Li,et al.  Raman spectra of CuO nanocrystals , 1999 .

[8]  Xiangyu Lv,et al.  An improved sensitivity nonenzymatic glucose biosensor based on a CuxO modified electrode. , 2010, Biosensors & bioelectronics.

[9]  Can Li,et al.  UV Raman spectroscopic studies on active sites and synthesis mechanisms of transition metal-containing microporous and mesoporous materials. , 2010, Accounts of chemical research.

[10]  Sangyun Park,et al.  Electrochemical analysis based on nanoporous structures. , 2012, The Analyst.

[11]  Ping Yang,et al.  Nanoporous gold supported cobalt oxide microelectrodes as high-performance electrochemical biosensors , 2013, Nature Communications.

[12]  A. Turner,et al.  Glucose oxidase: an ideal enzyme , 1992 .

[13]  Changli Li,et al.  A novel method to synthesize highly photoactive Cu2O microcrystalline films for use in photoelectrochemical cells. , 2014, ACS applied materials & interfaces.

[14]  Ali Al-Hajry,et al.  Enzymatic glucose biosensor based on flower-shaped copper oxide nanostructures composed of thin nanosheets , 2009 .

[15]  Joseph Wang.  Electrochemical glucose biosensors. , 2008, Chemical reviews.

[16]  Aicheng Chen,et al.  Nonenzymatic electrochemical glucose sensor based on nanoporous PtPb networks. , 2008, Analytical chemistry.

[17]  Roland Ulber,et al.  Challenges in integrating biosensors and FIA for on-line monitoring and control , 1996 .

[18]  C. Chung,et al.  The porous CuO electrode fabricated by hydrogen bubble evolution and its application to highly sensitive non-enzymatic glucose detection. , 2010, Talanta.

[19]  Hong Liu,et al.  Synthesis of CuO nanostructures and their application for nonenzymatic glucose sensing , 2010 .

[20]  Kang Wang,et al.  Highly Ordered Platinum‐Nanotubule Arrays for Amperometric Glucose Sensing , 2005 .

[21]  Jun Chen,et al.  UV Raman spectroscopic study on TiO2. I. Phase transformation at the surface and in the bulk. , 2006, The journal of physical chemistry. B.

[22]  R. Baldwin,et al.  Constant potential amperometric detection of carbohydrates at a copper-based chemically modified electrode , 1989 .

[23]  Bansi D. Malhotra,et al.  Sol-gel derived nanostructured cerium oxide film for glucose sensor , 2008 .

[24]  D. Cliffel,et al.  Electrochemical sensors and biosensors. , 2012, Analytical chemistry.

[25]  Katsuyoshi Hayashi,et al.  An amperometric detector formed of highly dispersed Ni nanoparticles embedded in a graphite-like carbon film electrode for sugar determination. , 2003, Analytical chemistry.

[26]  Theodore Kuwana,et al.  Electrochemical characterization of carbohydrate oxidation at copper electrodes , 1992 .

[27]  X. W. Sun,et al.  Zinc oxide nanocomb biosensor for glucose detection , 2006 .

[28]  T. Mallouk,et al.  Combinatorial discovery of alloy electrocatalysts for amperometric glucose sensors. , 2001, Analytical chemistry.

[29]  T. Chung,et al.  Ionic strength-controlled virtual area of mesoporous platinum electrode. , 2004, Journal of the American Chemical Society.

[30]  Martin Bartoš,et al.  AMPEROMETRIC DETERMINATION OF GLUCOSE WITH AN MnO2 AND GLUCOSE OXIDASE BULK-MODIFIED SCREEN-PRINTED CARBON INK BIOSENSOR , 2001 .

[31]  Yu Lei,et al.  CuO Nanospheres Based Nonenzymatic Glucose Sensor , 2008 .

[32]  R. Baldwin,et al.  Comparison of metallic electrodes for constant-potential amperometric detection of carbohydrates, amino acids and related compounds in flow systems , 1991 .

[33]  Lin Xu,et al.  Synthesis of graphene oxide based CuO nanoparticles composite electrode for highly enhanced nonenzymatic glucose detection. , 2013, ACS applied materials & interfaces.