Age Trends in Femur Stresses From a Simulated Fall on the Hip Among Men and Women: Evidence of Homeostatic Adaptation Underlying the Decline in Hip BMD

Age trends in proximal femur stresses were evaluated by simulating a fall on the greater trochanter using femur geometry from hip DXA scans of 5334 white men and women in the NHANES III survey. Expansion of femur outer diameter seems to counter net bone loss so that stresses remain similar across age groups, but stresses are higher in older women than in older men.

[1]  Hwj Rik Huiskes,et al.  Trabecular Bone Tissue Strains in the Healthy and Osteoporotic Human Femur , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  C. Ruff,et al.  Curved beam model of the proximal femur for estimating stress using dual‐energy x‐ray absorptiometry derived structural geometry , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[3]  R. Heaney,et al.  Bone Dimensional Change with Age: Interactions of Genetic, Hormonal, and Body Size Variables , 1997, Osteoporosis International.

[4]  Benjamin W. Schafer,et al.  Local, Distortional, and Euler Buckling of Thin-Walled Columns , 2002 .

[5]  Richmond W. Smith,et al.  Femoral Expansion in Aging Women: Implications for Osteoporosis and Fractures , 1964, Science.

[6]  M. Järvinen,et al.  Majority of Hip Fractures Occur as a Result of a Fall and Impact on the Greater Trochanter of the Femur: A Prospective Controlled Hip Fracture Study with 206 Consecutive Patients , 1999, Calcified Tissue International.

[7]  C. Thomas,et al.  Relation between age, femoral neck cortical stability, and hip fracture risk , 2005, The Lancet.

[8]  D Aubry,et al.  Effect of microstructure on the mechanical properties of Haversian cortical bone. , 2006, Bone.

[9]  S. Bandinelli,et al.  Structural adaptations to bone loss in aging men and women. , 2006, Bone.

[10]  H. Wahner,et al.  Quality control of bone densitometry in a national health survey (NHANES III) using three mobile examination centers , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[11]  W. O'Fallon,et al.  Cross-Sectional Versus Longitudinal Evaluation of Bone Loss in Men and Women , 2000, Osteoporosis International.

[12]  C. Lovejoy Evolution of human walking. , 1988, Scientific American.

[13]  W. Hayes,et al.  Sex differences in age‐related remodeling of the femur and tibia , 1988, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[14]  D B Burr,et al.  Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry. , 1984, Journal of biomechanics.

[15]  R. Klein,et al.  The evolution of human walking , 2005 .

[16]  J A McGeough,et al.  Age-Related Changes in the Compressive Strength of Cancellous Bone. The Relative Importance of Changes in Density and Trabecular Architecture* , 1997, The Journal of bone and joint surgery. American volume.

[17]  G S Beaupré,et al.  Mechanobiologic influences in long bone cross-sectional growth. , 1993, Bone.

[18]  T. Keaveny,et al.  Cortical and Trabecular Load Sharing in the Human Vertebral Body , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  J A McGeough,et al.  Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure. , 1993, The Journal of bone and joint surgery. American volume.

[20]  Lovejoy Co Evolution of Human Walking , 1988 .

[21]  H Weinans,et al.  Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level. , 2002, Bone.

[22]  Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94. Series 1: programs and collection procedures. , 1994, Vital and health statistics. Ser. 1, Programs and collection procedures.

[23]  W C Hayes,et al.  Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. , 1982, Science.

[24]  C. Thomas,et al.  Regional variations in cortical modeling in the femoral mid-shaft: sex and age differences. , 2000, American journal of physical anthropology.

[25]  Michael Witt,et al.  SUDAAN User's Manual, Release 9.0 , 2002 .

[26]  A. Boyde,et al.  Bone mineralization density and femoral neck fragility. , 2004, Bone.

[27]  T J Beck,et al.  Structural Trends in the Aging Femoral Neck and Proximal Shaft: Analysis of the Third National Health and Nutrition Examination Survey Dual‐Energy X‐Ray Absorptiometry Data , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.