Cerebral blood flow during orthostasis : role of arterial CO 2

J. M. Serrador, R. L. Hughson, J. M. Kowalchuk, R. L. Bondar, and A. W. Gelb Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada; Canadian Centre for Activity and Aging, School of Kinesiology, and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Sunnybrook and Women’s Health Sciences Centre, Toronto, Ontario, Canada; and Department of Anaesthesia, University of California, San Francisco, San Francisco, California

[1]  N. Secher,et al.  Standing up to the challenge of standing: a siphon does not support cerebral blood flow in humans. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[2]  Ronald Wilders,et al.  Tidal volume, cardiac output and functional residual capacity determine end‐tidal CO2 transient during standing up in humans , 2004, The Journal of physiology.

[3]  Kojiro Ide,et al.  Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans. , 2003, Journal of applied physiology.

[4]  Jorge M. Serrador,et al.  Head position modifies cerebrovascular response to orthostatic stress , 2003, Brain Research.

[5]  Richard L Hughson,et al.  Dynamic modulation of cerebrovascular resistance as an index of autoregulation under tilt and controlled PET(CO(2)). , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[6]  Rong Zhang,et al.  Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight , 2002, The Journal of physiology.

[7]  R. Hughson,et al.  Inspiratory CO2 increases orthostatic tolerance during repeated tilt. , 2001, Aviation, space, and environmental medicine.

[8]  R. Hughson,et al.  Critical Analysis of Cerebrovascular Autoregulation During Repeated Head-Up Tilt , 2001, Stroke.

[9]  John F. Potter,et al.  Cerebral Autoregulatory Responses to Head-Up Tilt in Normal Subjects and Patients With Recurrent Vasovagal Syncope , 2001, Circulation.

[10]  N. Secher,et al.  Muscle Tensing During Standing: Effects on Cerebral Tissue Oxygenation and Cerebral Artery Blood Velocity , 2001, Stroke.

[11]  J. Shoemaker,et al.  Cerebral vasoconstriction precedes orthostatic intolerance after parabolic flight , 2000, Brain Research Bulletin.

[12]  B K Rutt,et al.  MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. , 2000, Stroke.

[13]  J. Saavedra,et al.  Angiotensin and Cerebral Blood Flow , 1999, Cellular and Molecular Neurobiology.

[14]  P. Sándor,et al.  Nervous control of the cerebrovascular system: doubts and facts , 1999, Neurochemistry International.

[15]  R. Hughson,et al.  Ventilatory response to passive head up tilt. , 1998, Advances in experimental medicine and biology.

[16]  P. Novak,et al.  Hypocapnia and cerebral hypoperfusion in orthostatic intolerance. , 1998, Stroke.

[17]  H. Yoshizaki,et al.  Effect of posture change on control of ventilation. , 1998, The Japanese journal of physiology.

[18]  D. Kosinski,et al.  Cerebral Syncope: Loss of Consciousness Associated with Cerebral Vasoconstriction in the Absence of Systemic Hypotension , 1998, Pacing and clinical electrophysiology : PACE.

[19]  B. Levine,et al.  Effects of head-down-tilt bed rest on cerebral hemodynamics during orthostatic stress. , 1997, Journal of applied physiology.

[20]  T. Wein,et al.  Cerebrovascular and cardiovascular measurements during neurally mediated syncope induced by head-up tilt. , 1997, Stroke.

[21]  E. Länsimies,et al.  Regional cerebral perfusion in cardiovascular reflex syncope , 1997, European Journal of Nuclear Medicine.

[22]  M. L. Riedesel,et al.  Simultaneous cerebrovascular and cardiovascular responses during presyncope. , 1995, Stroke.

[23]  O. Paulson,et al.  Cerebral blood flow autoregulation and transcranial doppler sonography in patients with cirrhosis , 1995, Hepatology.

[24]  T. Higuchi,et al.  Evaluation of Cerebral Blood Flow in Patients With Idiopathic Orthostatic Hypotension Using Tc‐99m HMPAO Brain SPECT During Postural Testing , 1995, Clinical nuclear medicine.

[25]  J. Taylor,et al.  ‘Non‐hypotensive’ hypovolaemia reduces ascending aortic dimensions in humans. , 1995, The Journal of physiology.

[26]  O B Paulson,et al.  Transcranial Doppler Is Valid for Determination of the Lower Limit of Cerebral Blood Flow Autoregulation , 1994, Stroke.

[27]  Cole A. Giller,et al.  Cerebral Versus Systemic Hemodynamics During Graded Orthostatic Stress in Humans , 1994, Circulation.

[28]  B. Bishop,et al.  Control of breathing patterns and abdominal muscles during graded loads and tilt. , 1994, Journal of applied physiology.

[29]  R. Hughson,et al.  Heart rate variability and fractal dimension during orthostatic challenges. , 1993, Journal of applied physiology.

[30]  S. Warkentin,et al.  Cortical blood flow during head-up postural change in subjects with orthostatic hypotension , 1993, Clinical Autonomic Research.

[31]  L. Rowell Human Cardiovascular Control , 1993 .

[32]  B. Grubb,et al.  Cerebral Vasoconstriction During Head‐Upright Tilt‐Induced Vasovagal Syncope: A Paradoxic and Unexpected Response , 1991, Circulation.

[33]  J. Hughes Regional lung function: physiology and clinical applications. , 1985, Clinical physiology.

[34]  L E Farhi,et al.  Cardiopulmonary readjustments in passive tilt. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[35]  J. Loeppky,et al.  Fluctuations in O2 stores and gas exchange with passive changes in posture. , 1975, Journal of applied physiology.

[36]  N. Anthonisen,et al.  Distribution of pulmonary perfusion in erect man. , 1966, Journal of applied physiology.

[37]  N. Anthonisen,et al.  Postural effect on ventilatory control , 1965 .

[38]  H. Rahn,et al.  DYNAMICS OF CHANGES IN CARBON DIOXIDE STORES. TECHN DOCUM REP AMRL-TDR-63-103 (I). , 1963, AMRL-TR. Aerospace Medical Research Laboratories.

[39]  H RAHN,et al.  Dynamics of changes in carbon dioxide stores. , 1960, Anesthesiology.

[40]  Z. Topor,et al.  Assessment of ventilatory sensitivity to carbon dioxide changes during orthostasis. , 2002, Biomedical sciences instrumentation.

[41]  G. Leftheriotis,et al.  Effect of head-upright tilt on the dynamic of cerebral autoregulation. , 1998, Clinical physiology.

[42]  R. Hughson,et al.  Advances in Modeling and Control of Ventilation , 1998, Advances in Experimental Medicine and Biology.

[43]  K. Hayashida,et al.  Maladaptation of vascular response in frontal area of patients with orthostatic hypotension. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[44]  O B Paulson,et al.  Cerebral autoregulation. , 1984, Stroke.

[45]  Y Miyamoto,et al.  The dynamic response of the cardiopulmonary parameters to passive head-up tilt. , 1982, The Japanese journal of physiology.

[46]  H BJURSTEDT,et al.  Effects of posture on alveolar-arterial CO2 and O2 differences and on alveolar dead space in man. , 1962, Acta physiologica Scandinavica.