Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition.

Defocusing, vignetting, and bulk motion degrade the image quality of optical coherence tomography angiography (OCTA) more significantly than structural OCT. The assessment of focus, alignment conditions, and stability of imaging subjects in commercially available OCTA systems are currently based on OCT signal quality alone, without knowledge of OCTA signal quality. This results in low yield rates for further quantification. In this Letter, we developed a novel OCTA platform based on a graphics processing unit (GPU) for a real-time, high refresh rate, B-san-by-B-scan split-spectrum amplitude-decorrelation angiography. The GPU provides a real-time display of both cross-sectional and en face images to assist operators during scan acquisition and ensure OCTA scan quality.

[1]  David Huang,et al.  Advanced image processing for optical coherence tomographic angiography of macular diseases. , 2015, Biomedical optics express.

[2]  David Huang,et al.  Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology. , 2016, Biomedical optics express.

[3]  Suhwan Kim,et al.  High Speed SD-OCT System Using GPU Accelerated Mode for in vivo Human Eye Imaging , 2013 .

[4]  Gangjun Liu,et al.  Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT. , 2017, Biomedical optics express.

[5]  Yuuki Watanabe,et al.  Real-time display on Fourier domain optical coherence tomography system using a graphics processing unit. , 2009, Journal of biomedical optics.

[6]  Anthony N Kuo,et al.  Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT , 2016, Biomedical optics express.

[7]  Kevin Wong,et al.  Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit , 2014, Journal of biomedical optics.

[8]  Iwona Gorczynska,et al.  Four-dimensional structural and Doppler optical coherence tomography imaging on graphics processing units , 2012, Journal of biomedical optics.

[9]  Michelle Cua,et al.  Retinal angiography with real-time speckle variance optical coherence tomography , 2015, British Journal of Ophthalmology.

[10]  David Huang,et al.  Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography , 2016, Investigative ophthalmology & visual science.

[11]  T. Yatagai,et al.  Optical coherence angiography. , 2006, Optics express.

[12]  Ruikang K. Wang,et al.  In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography. , 2008, Optics express.

[13]  Adrian Mariampillai,et al.  Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit , 2012, Biomedical optics express.

[14]  David J. Wilson,et al.  Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography , 2017, Scientific Reports.

[15]  Martin F. Kraus,et al.  Split-spectrum amplitude-decorrelation angiography with optical coherence tomography , 2012, Optics express.