High Resolution Optical Coherence Tomography

Imaging cellular and extracellular structures and processes in situ and in vivo is highly desired for the understanding and diagnosis of human diseases. High resolution optical coherence tomography (HR-OCT) is particularly suitable for this task because it can provide real-time, 3-D images of a large tissue volume at subcellular resolution. Over the past two decades, tremendous technical advances have been made to tackle the fundamental and practical limitations of HR-OCT for applications in various clinical fields. Meanwhile, novel scientific and clinical applications of HR-OCT have also been proposed and validated. This review aims to provide an update on the progress of technology development, with a focus on axial focus extension, aberration correction, and fiber-optic probe development. This review also aims to summarize the newly established capabilities of HR-OCT in fundamental and clinical research, in an effort to promote multidisciplinary research using this powerful imaging tool.

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[71]  Geunyoung Yoon,et al.  Micrometer axial resolution OCT for corneal imaging , 2011, Biomedical optics express.

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[75]  Jianhua Mo,et al.  Imaging Cellular Structures of Atherosclerotic Coronary Arteries Using Circumferentially Scanning Micro-Optical Coherence Tomography Fiber Probe Ex Vivo , 2018, IEEE Access.

[76]  Jianhua Wang,et al.  Precorneal and pre- and postlens tear film thickness measured indirectly with optical coherence tomography. , 2003, Investigative ophthalmology & visual science.

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[78]  Linbo Liu,et al.  A functional anatomic defect of the cystic fibrosis airway. , 2014, American journal of respiratory and critical care medicine.

[79]  Johannes F de Boer,et al.  Depth-encoded synthetic aperture optical coherence tomography of biological tissues with extended focal depth. , 2015, Optics express.

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[81]  Zhihua Ding,et al.  High-resolution optical coherence tomography over a large depth range with an axicon lens. , 2002, Optics letters.

[82]  Biwei Yin,et al.  μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe. , 2016, Optics express.

[83]  J. Qiu,et al.  Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe. , 2020, Optics letters.

[84]  Ping Shum,et al.  Multifiber angular compounding optical coherence tomography for speckle reduction. , 2017, Optics letters.

[85]  Linbo Liu,et al.  Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis , 2017 .

[86]  Linbo Liu,et al.  Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography , 2014, PloS one.

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[95]  Linbo Liu,et al.  Geometry-Dependent Spectroscopic Contrast in Deep Tissues , 2019, iScience.

[96]  Linbo Liu,et al.  Ion Channels and Transporters in Lung Function and Disease Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy , 2016 .

[97]  Wolfgang Drexler,et al.  Subaperture correlation based digital adaptive optics for full field optical coherence tomography. , 2013, Optics express.

[98]  Xingde Li,et al.  Noninvasive assessment of cutaneous wound healing using ultrahigh-resolution optical coherence tomography. , 2006, Journal of biomedical optics.

[99]  Daniel L Marks,et al.  Inverse scattering for frequency-scanned full-field optical coherence tomography. , 2007, Journal of the Optical Society of America. A, Optics, image science, and vision.

[100]  Wooyoung Jang,et al.  Complex wavefront shaping for optimal depth-selective focusing in optical coherence tomography. , 2013, Optics express.

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[102]  Angelika Unterhuber,et al.  Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections. , 2004, Experimental eye research.

[103]  Angelika Unterhuber,et al.  Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina. , 2008, Optics express.

[104]  Meng-Tsan Tsai,et al.  Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser. , 2019, Biomedical optics express.

[105]  Woonggyu Jung,et al.  Aberration characterization for the optimal design of high-resolution endoscopic optical coherence tomography catheters. , 2012, Optics letters.

[106]  R. Leitgeb,et al.  Extended focus depth for Fourier domain optical coherence microscopy. , 2006, Optics letters.

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[108]  Chung-Ho Sun,et al.  Imaging subcellular scattering contrast by using combined optical coherence and multiphoton microscopy. , 2007, Optics letters.

[109]  Xinyu Liu,et al.  Modeling of Mechanical Stress Exerted by Cholesterol Crystallization on Atherosclerotic Plaques , 2016, PloS one.

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