The central role of DNA damage in the ageing process

[1]  B. Schumacher,et al.  H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage , 2020, Nature Structural & Molecular Biology.

[2]  M. Rieckher,et al.  A C. elegans model for neurodegeneration in Cockayne syndrome , 2020, Nucleic acids research.

[3]  Cécile Mingard,et al.  Next-generation DNA damage sequencing. , 2020, Chemical Society reviews.

[4]  Lin S. Chen,et al.  Determinants of telomere length across human tissues , 2020, Science.

[5]  J. Gietema,et al.  Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act. , 2020, Critical reviews in oncology/hematology.

[6]  A. Masuda,et al.  Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair , 2020, Cell.

[7]  Malin Larsson,et al.  Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type , 2019, Genome Biology.

[8]  C. Schmitt,et al.  Cellular Senescence: Defining a Path Forward , 2019, Cell.

[9]  H. Nakane,et al.  High levels of oxidatively generated DNA damage 8,5'-cyclo-2'-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A gene-knockout mice. , 2019, DNA repair.

[10]  B. Schumacher,et al.  Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. , 2019, Developmental cell.

[11]  H. Yanai,et al.  DNA damage in aging, the stem cell perspective , 2019, Human Genetics.

[12]  M. Jasiulionis,et al.  The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer , 2019, International journal of molecular sciences.

[13]  B. Schumacher,et al.  Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans , 2019, Genetics.

[14]  J. Grimsby,et al.  RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues , 2019, Science.

[15]  S. Dokudovskaya,et al.  mTORC1 pathway in DNA damage response , 2019, Biopolymers and Cell.

[16]  A. Chakraborty,et al.  Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription , 2019, eLife.

[17]  Zhengdong D. Zhang,et al.  SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species , 2019, Cell.

[18]  K. Patel,et al.  Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling , 2019, Journal of cachexia, sarcopenia and muscle.

[19]  D. Mari,et al.  Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution , 2019, Genome Research.

[20]  Eva Terzibasi Tozzini,et al.  Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation , 2019, bioRxiv.

[21]  J. Vijg,et al.  Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver , 2019, Science Advances.

[22]  J. Vijg,et al.  Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan , 2019, Proceedings of the National Academy of Sciences.

[23]  Alex P. Reiner,et al.  DNA methylation GrimAge strongly predicts lifespan and healthspan , 2019, Aging.

[24]  T. Carell,et al.  Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides , 2018, Nature Protocols.

[25]  J. Vijg,et al.  Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging. , 2018, Annual review of genetics.

[26]  T. de Lange.  Shelterin-Mediated Telomere Protection. , 2018, Annual review of genetics.

[27]  Tom H. Cheung,et al.  Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. , 2018, Cell stem cell.

[28]  M. Stratton,et al.  Population dynamics of normal human blood inferred from somatic mutations , 2018, Nature.

[29]  P. Robbins,et al.  Nuclear Genomic Instability and Aging. , 2018, Annual review of biochemistry.

[30]  S. Boulton,et al.  Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place. , 2018, Cancer discovery.

[31]  Shane A. Evans,et al.  Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage-and Histone Methylation-Dependent Pathways , 2018, Cell reports.

[32]  A. Pagnani,et al.  Somatic mutagenesis in satellite cells associates with human skeletal muscle aging , 2018, Nature Communications.

[33]  Peter J. Park,et al.  Aging and neurodegeneration are associated with increased mutations in single human neurons , 2017, Science.

[34]  S. Gasser,et al.  Chromatin and nucleosome dynamics in DNA damage and repair , 2017, Genes & development.

[35]  B. Schumacher,et al.  Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans , 2017, Cell reports.

[36]  Kari Stefansson,et al.  Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. , 2017, Blood.

[37]  S. Katiyar,et al.  Crosstalk Among UV‐Induced Inflammatory Mediators, DNA Damage and Epigenetic Regulators Facilitates Suppression of the Immune System , 2017, Photochemistry and photobiology.

[38]  J. Elisseeff,et al.  Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment , 2017, Nature Medicine.

[39]  M. Blasco,et al.  Telomere-driven diseases and telomere-targeting therapies , 2017, The Journal of cell biology.

[40]  David M. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[41]  A. Barzilai,et al.  Genome instability: Linking ageing and brain degeneration , 2017, Mechanisms of Ageing and Development.

[42]  S. Gonzalo,et al.  Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations , 2017, Ageing Research Reviews.

[43]  S. Tabrizi,et al.  DNA repair in the trinucleotide repeat disorders , 2017, The Lancet Neurology.

[44]  N. Larsson,et al.  Mammalian Mitochondria and Aging: An Update. , 2017, Cell metabolism.

[45]  Keith W. Caldecott,et al.  XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia , 2016, Nature.

[46]  C. Conover,et al.  Senescent intimal foam cells are deleterious at all stages of atherosclerosis , 2016, Science.

[47]  L. Santambrogio,et al.  Whole Chromosome Instability induces senescence and promotes SASP , 2016, Scientific Reports.

[48]  A. Uitterlinden,et al.  Menopause: Genome stability as new paradigm. , 2016, Maturitas.

[49]  A. Porcellini,et al.  DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism , 2016, Scientific Reports.

[50]  Richard A. Miller,et al.  mTOR regulates the expression of DNA damage response enzymes in long‐lived Snell dwarf, GHRKO, and PAPPA‐KO mice , 2016, Aging cell.

[51]  Carlos López-Otín,et al.  Metabolic Control of Longevity , 2016, Cell.

[52]  F. d’Adda di Fagagna,et al.  NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex , 2016, Cell reports.

[53]  J. Pennings,et al.  Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice , 2016, Nature.

[54]  J. Shay,et al.  Role of Telomeres and Telomerase in Aging and Cancer. , 2016, Cancer discovery.

[55]  W. V. van IJcken,et al.  Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease , 2016, Cell reports.

[56]  J. Hoeijmakers,et al.  Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis , 2016, Science.

[57]  M. Velarde,et al.  Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. , 2016, Cell metabolism.

[58]  Alex Zhavoronkov,et al.  Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes , 2015, Scientific Reports.

[59]  J. Vijg,et al.  Genetic evidence for common pathways in human age-related diseases , 2015, Aging cell.

[60]  P. Khaitovich,et al.  Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging , 2015, Genome Biology.

[61]  J. Hoeijmakers,et al.  An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. , 2014, Developmental cell.

[62]  Bernhard Schermer,et al.  DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage , 2014, Nature Cell Biology.

[63]  Frédérique Magdinier,et al.  Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances , 2014, Genes & development.

[64]  M. L. Beau,et al.  Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells , 2014, Nature.

[65]  I. Weissman,et al.  Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. , 2014, Cell stem cell.

[66]  L. Brace,et al.  Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction , 2014, Cell.

[67]  Wei Li,et al.  Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging , 2014, Genes & development.

[68]  I. Demuth,et al.  DNA-repair in mild cognitive impairment and Alzheimer's disease. , 2013, DNA repair.

[69]  Björn Schumacher,et al.  DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance , 2013, Nature.

[70]  J. Hoeijmakers,et al.  Nucleotide excision repair in chronic neurodegenerative diseases. , 2013, DNA repair.

[71]  L. Partridge,et al.  The Hallmarks of Aging , 2013, Cell.

[72]  J. Moriguti,et al.  Lymphocytes of Patients with Alzheimer’s Disease Display Different DNA Damage Repair Kinetics and Expression Profiles of DNA Repair and Stress Response Genes , 2013, International journal of molecular sciences.

[73]  H. Geiger,et al.  The ageing haematopoietic stem cell compartment , 2013, Nature Reviews Immunology.

[74]  B. Viollet,et al.  Role of AMPK in UVB-induced DNA damage repair and growth control , 2012, Oncogene.

[75]  F. D. D. Fagagna,et al.  Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation , 2012, Nature Cell Biology.

[76]  Ziv Bar-Joseph,et al.  The sirtuin SIRT6 regulates lifespan in male mice , 2012, Nature.

[77]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[78]  Max Ingman,et al.  Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins , 2011, PLoS genetics.

[79]  J. Campisi,et al.  DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion , 2011, Journal of Cell Science.

[80]  Shan Jiang,et al.  Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice , 2010, Nature.

[81]  Stuart L Schreiber,et al.  Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres , 2010, Nature Structural &Molecular Biology.

[82]  M. Warr,et al.  Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. , 2010, Cell stem cell.

[83]  M. Obulesu,et al.  DNA Damage and Impairment of DNA Repair in Alzheimer's Disease , 2010, The International journal of neuroscience.

[84]  E. Gilson,et al.  A two-step model for senescence triggered by a single critically short telomere , 2009, Nature Cell Biology.

[85]  J. Campisi,et al.  Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion , 2009, Nature Cell Biology.

[86]  T. Breit,et al.  Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity , 2009, Nature Cell Biology.

[87]  F. Alt,et al.  SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging , 2008, Cell.

[88]  T. Breit,et al.  Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms , 2008, PLoS genetics.

[89]  M. Mattson,et al.  Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment , 2007, Nucleic acids research.

[90]  Irving L. Weissman,et al.  Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age , 2007, Nature.

[91]  A. Trumpp,et al.  Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment , 2007, Nature Medicine.

[92]  B. A. Ballif,et al.  ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage , 2007, Science.

[93]  T. Prolla,et al.  Mitochondrial point mutations do not limit the natural lifespan of mice , 2007, Nature Genetics.

[94]  J. Hoeijmakers,et al.  A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis , 2006, Nature.

[95]  S. Salamat,et al.  Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. , 2006, American journal of human genetics.

[96]  Jan Vijg,et al.  Increased cell-to-cell variation in gene expression in ageing mouse heart , 2006, Nature.

[97]  C. Geula,et al.  Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons , 2006, Nature Genetics.

[98]  Pingfang Liu,et al.  Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 , 2006, Cell.

[99]  T. D. Pugh,et al.  Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging , 2005, Science.

[100]  H. Leonhardt,et al.  Recruitment of DNA methyltransferase I to DNA repair sites. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[101]  F. Gruijl,et al.  Powerful Skin Cancer Protection by a CPD-Photolyase Transgene , 2005, Current Biology.

[102]  Howard T. Jacobs,et al.  Premature ageing in mice expressing defective mitochondrial DNA polymerase , 2004, Nature.

[103]  J. Barrett,et al.  Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks , 2004, Nature Cell Biology.

[104]  Laura C. Greaves,et al.  Mitochondrial DNA mutations in human colonic crypt stem cells. , 2003, The Journal of clinical investigation.

[105]  J. Hoeijmakers,et al.  Premature Aging in Mice Deficient in DNA Repair and Transcription , 2002, Science.

[106]  J. Campisi,et al.  Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[107]  J. Aiken,et al.  Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[108]  B. Van Houten,et al.  Measuring gene-specific nucleotide excision repair in human cells using quantitative amplification of long targets from nanogram quantities of DNA. , 2000, Mutation research.

[109]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[110]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[111]  T. Lindahl.  Instability and decay of the primary structure of DNA , 1993, Nature.

[112]  J. Szostak,et al.  A mutant with a defect in telomere elongation leads to senescence in yeast , 1989, Cell.

[113]  L. Becker,et al.  Cockayne's syndrome: report of two autopsy cases associated with neurofibrillary tangles. , 1986, Clinical neuropathology.

[114]  H. Bernstein,et al.  DNA Damage as the Primary Cause of Aging , 1981, The Quarterly Review of Biology.

[115]  R B Setlow,et al.  Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[116]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.

[117]  George C. Williams,et al.  PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE , 1957, Science of Aging Knowledge Environment.

[118]  D. Harman.  Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.

[119]  Denham. Harraan.  AGING: A THEORY BASED ON FREE RADICAL AND RADIATION CHEMISTRY , 1955 .

[120]  P. S. Henshaw,et al.  The biologic effects of pile radiations. , 1947, Radiology.

[121]  L. Maynard,et al.  Retarded Growth, Life Span, Ultimate Body Size and Age Changes in the Albino Rat after Feeding Diets Restricted in Calories Four Figures , 1939 .

[122]  George Rajna.  Link Between Cancer and Aging , 2018 .

[123]  E. Kelly,et al.  an update on , 2014 .

[124]  M. Parry,et al.  Time to act , 2009, Nature.

[125]  P. Alexander.  The role of DNA lesions in the processes leading to aging in mice. , 1967, Symposia of the Society for Experimental Biology.

[126]  John D. Eicher,et al.  Nature Genetics Advance Online Publication Large-scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility and Brca1-mediated Dna Repair , 2022 .